Morihiro Kunihiko

Affiliation and department：
Homepage URL (1)： http://park.itc.u-tokyo.ac.jp/okamoto/

Research field (1)： Bioorganic chemistry

Research theme for competitive and other funds (20)：

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Papers (40)：

Yuyuan Chen, Kunihiko Morihiro, Yui Nemoto, Akito Ichimura, Ryosuke Ueki, Shinsuke Sando, Akimitsu Okamoto. Selective inhibition of cancer cell migration using a pH-responsive nucleobase-modified DNA aptamer. Chemical Science. 2024. 15. 41. 17097-17102
Minako Narita, Ai KOHATA, Taiichi Kageyama, Honoka Watanabe, Kohsuke Aikawa, Daisuke Kawaguchi, Kunihiko Morihiro, Akimitsu Okamoto, Takashi Okazoe. Fluorocarbon-DNA conjugates for enhanced cellular delivery: Formation of a densely packed DNA nano-assembly. ChemBioChem. 2024
Kunihiko Morihiro, Yasuhiro Tomida, Honami Ando, Akimitsu Okamoto. Copper-mediated siRNA activation for conditional control of gene expression. Bioorganic & Medicinal Chemistry Letters. 2024. 104. 129738-129738
Kunihiko Morihiro, Shunto Morita, Naoki Harada, Manami Baba, Jongmin Yum, Mitsuru Naito, Kanjiro Miyata, Genta Nagae, Akimitsu Okamoto. RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality. Journal of the American Chemical Society. 2024. 146. 2. 1346-1355
Masako Takatsu, Kunihiko Morihiro, Honoka Watanabe, Mizue Yuki, Takara Hattori, Kentaro Noi, Kohsuke Aikawa, Keiichi Noguchi, Masafumi Yohda, Takashi Okazoe, et al. Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery. ACS Chemical Biology. 2023

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Patents (5)：

Books (5)：

Lectures and oral presentations (40)：

Anticancer Nucleic Acid Therapeutics through Excessive Activation of RNase H
(FIBER 核酸化学ユニバース Rising Stars 2024)
Selective Inhibition of Cancer Cell Migration Using pH-Responsive DNA Aptamer
(2024)
細胞内核酸集合技術を使った創薬研究
(核酸化学若手フォーラム2023 2023)
Drug Discovery Using Nucleic Acid Nanotechnology
(FIBER Webinar Universe Rising Stars 2023)
Tumor immune activation through intracellular hairpin DNA assembly
(18th Annual Meeting of the Oligonucleotide Therapeutics Society 2022)

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Education (3)：

2010 - 2013 Osaka University Graduate School of Pharmaceutical Sciences Applied Biopharmaceutical Sciences
2008 - 2010 Osaka University Graduate School of Pharmaceutical Sciences Applied Biopharmaceutical Sciences
2004 - 2008 Osaka University School of Pharmaceutical Sciences Department of Pharmaceutical Sciences

Professional career (1)：

Work history (6)：

2024/02 - 現在 The University of Tokyo Department of Chemistry and Biotechnology, Graduate School of Engineering Associate Professor
2022/04 - 現在東京核酸合成株式会社技術顧問
2017/03 - 2024/01 The University of Tokyo The Graduate School of Engineering, Department of Chemistry and Biotechnology
2015/04 - 2017/02 日本学術振興会海外特別研究員 (米国ピッツバーグ大学)
2013/04 - 2015/03 医薬基盤研究所創薬支援スクリーニングセンター特任研究員

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Committee career (3)：

Awards (7)：

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