Morihiro Kunihiko

Affiliation and department：
Homepage URL (1)： http://park.itc.u-tokyo.ac.jp/okamoto/

Research field (1)： Bioorganic chemistry

Research theme for competitive and other funds (19)：

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Papers (37)：

Kunihiko Morihiro, Yasuhiro Tomida, Honami Ando, Akimitsu Okamoto. Copper-mediated siRNA activation for conditional control of gene expression. Bioorganic & Medicinal Chemistry Letters. 2024. 104. 129738-129738
Kunihiko Morihiro, Shunto Morita, Naoki Harada, Manami Baba, Jongmin Yum, Mitsuru Naito, Kanjiro Miyata, Genta Nagae, Akimitsu Okamoto. RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality. Journal of the American Chemical Society. 2024. 146. 2. 1346-1355
Masako Takatsu, Kunihiko Morihiro, Honoka Watanabe, Mizue Yuki, Takara Hattori, Kentaro Noi, Kohsuke Aikawa, Keiichi Noguchi, Masafumi Yohda, Takashi Okazoe, et al. Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery. ACS Chemical Biology. 2023
Shan Liu, Kunihiko Morihiro, Fumika Takeuchi, Yufeng Li, Akimitsu Okamoto. Interstrand crosslinking oligonucleotides elucidate the effect of metal ions on the methylation status of repetitive DNA elements. Frontiers in Chemistry. 2023. 11
Kunihiko Morihiro, Hiraki Osumi, Shunto Morita, Takara Hattori, Manami Baba, Naoki Harada, Riuko Ohashi, Akimitsu Okamoto. Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly. Journal of the American Chemical Society. 2022. 145. 1. 135-142

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Patents (5)：

Books (5)：

Lectures and oral presentations (38)：

Selective Inhibition of Cancer Cell Migration Using pH-Responsive DNA Aptamer
(2024)
Drug Discovery Using Nucleic Acid Nanotechnology
(FIBER Webinar Universe Rising Stars 2023)
Tumor immune activation through intracellular hairpin DNA assembly
(18th Annual Meeting of the Oligonucleotide Therapeutics Society 2022)
腫瘍溶解性ヘアピンDNAペア:マイクロRNA駆動型DNA自己組織化を介した選択的細胞毒性誘導剤
(第16回バイオ関連化学シンポジウム 2022)
がん選択的な免疫療法を可能にするヘアピン型DNA医薬
(日本核酸医薬学会第7回年会 2022)

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Education (3)：

2010 - 2013 Osaka University Graduate School of Pharmaceutical Sciences Applied Biopharmaceutical Sciences
2008 - 2010 Osaka University Graduate School of Pharmaceutical Sciences Applied Biopharmaceutical Sciences
2004 - 2008 Osaka University School of Pharmaceutical Sciences Department of Pharmaceutical Sciences

Professional career (1)：

Work history (6)：

2024/02 - 現在 The University of Tokyo Department of Chemistry and Biotechnology, Graduate School of Engineering Associate Professor
2022/04 - 現在東京核酸合成株式会社技術顧問
2017/03 - 2024/01 The University of Tokyo The Graduate School of Engineering, Department of Chemistry and Biotechnology
2015/04 - 2017/02 日本学術振興会海外特別研究員 (米国ピッツバーグ大学)
2013/04 - 2015/03 医薬基盤研究所創薬支援スクリーニングセンター特任研究員

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Committee career (3)：

Awards (7)：

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