Nakano Keisuke

Affiliation and department：
Job title： Associate Professor

Research field (1)： Oral medicine (pathology)

Research theme for competitive and other funds (28)：

2023 - 2027 癌骨破壊病変において新規破骨細胞形成促進因子Angiogeninが果たす役割の解明
2023 - 2027 Selective induction of bone and cartilage differentiation and reconstruction of the mandibular condyle using miRNA and TCP hybrid biomaterials
2023 - 2026 バイオマテリアルin vitro安全性評価のためのgPAD-オルガノイドシステムの開発
2023 - 2026 Development of a novel treatment for ameloblastoma by modifying tumor stroma based on CCN2
2022 - 2025 口腔癌間質が主導する実質進展制御メカニズム解明と新規治療法開発

2021 - 2025 細胞競合による癌の生物学的性格および癌化の制御

2020 - 2025 口腔扁平上皮癌における新規遠隔転移抑制治療の開発

2020 - 2024 エナメル上皮腫の生物学的性格制御による腫瘍実質ー間質相互作用破綻の誘導

2020 - 2023 miRNAが支配する骨・軟骨分化方向決定メカニズムの解明

2018 - 2022 Regulation of the biological character of cancer and induction of cancer by the cancer stroma.

2017 - 2021 Drug repositioning using the gene promoter activity-based anticancer drug screening system

2016 - 2019 Involvement of bone marrow mesenchymal cells in the repair of dentin-pulp complex

2016 - 2019 Characterization and potential roles of bone marrow-derived stromal cells in premetastasis niche

2014 - 2017 Elucidation of the molecular mechanisms of the periodontal tissue repair

2014 - 2017 Molecular pathology of phenotypic chenges in lesions of jow bones

2014 - 2017 Pathogenesis research on oro-maxillary cytological proliferative lesions

2013 - 2016 Molecular control mechanism of cell suppling, migration and differentiation in remodeling of periodontal ligament

2013 - 2016 The effects of music on the pain thresholds and the balance of autonomic nerves

2011 - 2013 Elucidation of the molecular mechanisms of tissue repair using stem cells

2011 - 2013 Elucidation of the cell differentiation molecular regulation mechanism in proliferative lesions of the oral cavity using bone marrow stem cell transplantation model

2010 - 2012 Elucidation of mechanism of drug-induced gingival overgrowth and search for its therapeutic drugs

2010 - 2012 Elucidation of molecular regulation mechanism and promotion of the orthodontic remodeling using the bone marrow stem cell

2008 - 2010 Molecular regulation system of cytodifferentiation due to mechanical stress

2008 - 2010 Molecular mechanism of cyto-differentiation of proliferating bone resorping lesions

2007 - 2008 Molecule regulation mechanism of the cytodifferentiation in the remodeling of a maxillo-periodontal tissues from a view point of orthodontics.

2000 - 2002 Molecular pathological study of tooth germ and odonto genic tumor

2001 - 2001 歯胚の誘導制御における基底膜VI型コラーゲンα鎖の役割

1999 - 2001 Gene expression of BMP family and receptors during tooth development

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Papers (189)：

Yuki Shinoda-Ito, Anna Hirai, Kazuhiro Omori, Hidetaka Ideguchi, Hideki Yamamoto, Fumino Kato, Kyoichi Obata, Tatsuo Ogawa, Keisuke Nakano, Takato Nakadoi, et al. Ligneous periodontitis exacerbated by Behçet’s disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C > T: a case report. BMC Oral Health. 2023. 23. 1
Shintaro Sukegawa, Sawako Ono, Futa Tanaka, Yuta Inoue, Takeshi Hara, Kazumasa Yoshii, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Shimada Katsumitsu, et al. Effectiveness of deep learning classifiers in histopathological diagnosis of oral squamous cell carcinoma by pathologists. Scientific reports. 2023. 13. 1. 11676-11676
Hotaka Kawai, May Wathone Oo, Kiyofumi Takabatake, Ikue Tosa, Yamin Soe, Htoo Shwe Eain, Sho Sanou, Shigeko Fushimi, Shintaro Sukegawa, Keisuke Nakano, et al. Enzyme-Cleaved Bone Marrow Transplantation Improves the Engraftment of Bone Marrow Mesenchymal Stem Cells. JBMR plus. 2023. 7. 3. e10722
Yasunori Inada, Kiyofumi Takabatake, Hidetsugu Tsujigiwa, Keisuke Nakano, Qiusheng Shan, Tianyan Piao, Anqi Chang, Hotaka Kawai, Hitoshi Nagatsuka. Novel Artificial Scaffold for Bone Marrow Regeneration: Honeycomb Tricalcium Phosphate. Materials (Basel, Switzerland). 2023. 16. 4
佐々木朗, 坂本裕美, 中野敬介, 金本栄華, 吉岡徳枝, 竜門省二, 西山明慶, 志茂剛, 伊原木聰一郎. 癌の骨破壊病変に対する銅のキレートを応用した治療に関する基礎的検討. 日本口腔診断学会雑誌. 2023. 36. 1. 56-56

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MISC (108)：

武部祐一郎, 辻極秀次, 高畠清文, 稲田靖則, 藤井昌江, 河合穂高, 中野敬介, 長塚仁. Effect of CCN2 secreted by ameloblastoma on bone resorption through tumor stroma. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2023. 41st
稲田靖則, 高畠清文, 藤井昌江, 伏見滋子, 中野敬介, 長塚仁. Mechanism of marsupialization in ameloblastomamediated via HIF-1. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2023. 41st
稲田靖則, 高畠清文, 辻極秀次, 河合穂高, 中野敬介, 長塚仁. ハニカム構造を有するTCPを応用した骨髄組織誘導. 日本口腔科学会学術集会プログラム・抄録集. 2023. 77th
高畠清文, 稲田靖則, 藤井昌江, 河合穂高, 中野敬介. HIF-1αを介したエナメル上皮腫開窓術作用機序の解明. 日本口腔科学会学術集会プログラム・抄録集. 2023. 77th
助川信太郎, 小野早和子, 中野敬介, 長塚仁, 古木良彦. 口腔細胞診による口腔癌および前癌病変の一次スクリーニングの有用性. 日本臨床細胞学会雑誌(Web). 2021. 60

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Books (7)：

口腔癌 = Oral cancer
医歯薬出版 2023 ISBN:9784263423158
Clinical Concepts and Practical Management Techniques in Dentistry
IntechOpen 2022 ISBN:9781839628429
Inflammation and Oral Cancer From Bench to Bedside 1st Edition
Academic Press is an imprint of Elsevier 2021
新口腔病理学
医歯薬出版 2021 ISBN:9784263458594
病理組織の見方と鑑別診断
医歯薬出版 2020 ISBN:9784263731970

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Lectures and oral presentations (45)：

口腔扁平上皮癌腫瘍間質が腫瘍関連マクロファージの集族・分化に与える影響について
(第44回岡山歯学会総会・学術大会 2023)
口腔細胞診におけるNILM症例についての再検討
(第62回日本臨床細胞学会秋期大会 2023)
口腔扁平上皮癌における骨髄由来間葉系幹細胞の動態の検討
(第31回硬組織再生生物学会学術大会・総会 2023)
口腔扁平上皮癌の腫瘍血管形成におけるCXCR4の役割の検討
(第34回日本臨床口腔病理学会学術大会 2023)
口腔扁平上皮癌微小環境が腫瘍関連マクロファージ浸潤に与える影響について
(第34回日本臨床口腔病理学会学術大会 2023)

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Professional career (2)：

修士(学術) (北里大学)
博士(歯学) (岡山大学)

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