Akaike Toru

アカイケトオル | Akaike Toru

Affiliation and department：
Job title： Professor

Research field (3)： Clinical pharmacy , Physiology , Fetal medicine/Pediatrics

Research keywords (4)： vascular remodeling , ductus arteriosus , congenital heart disease , physiology

Research theme for competitive and other funds (9)：

2022 - 2025 酸素による内皮細胞を介した解剖学的動脈管閉鎖機構の探索
2021 - 2024 動脈管閉鎖の分子機構解明
2019 - 2022 酸素による血管リモデリングを標的とした動脈管閉鎖機構の解明
2017 - 2021 Characterization of specificity and pathophysiology in pulmonary veins
2016 - 2019 Troponin T replacement can be a new therapy for dilated cardiomyopathy

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Papers (36)：

Daiki Seya, Takahiro Inoue, Sunsuke Baba, Toru Akaike, Susumu Minamisawa. Abstract 16402: Pitx2c-Conditional Knockout Mice May Become a Useful Model to Elucidate the Pathogenesis of Post-Capillary Pulmonary Hypertension. Circulation. 2023. 148. Suppl_1
Ryuma Iwaki, Hironori Matsuhisa, Susumu Minamisawa, Toru Akaike, Masato Hoshino, Naoto Yagi, Kiyozo Morita, Gen Shinohara, Yukihiro Kaneko, Syuichi Yoshitake, et al. Evaluation of Ductal Tissue in Coarctation of the Aorta Using X-Ray Phase-Contrast Tomography. Pediatric Cardiology. 2021. 42. 3. 654-661
Yuki Yamada, Yoichiro Kusakari, Munetoshi Akaoka, Masato Watanabe, Jun Tanihata, Naritomo Nishioka, Hiroki Bochimoto, Toru Akaike, Toshiaki Tachibana, Susumu Minamisawa. Thiamine treatment preserves cardiac function against ischemia injury via maintaining mitochondrial size and ATP levels. Journal of Applied Physiology. 2021. 130. 1. 26-35
Ryuma Iwaki, Hironori Matsuhisa, Susumu Minamisawa, Toru Akaike, Masato Hoshino, Naoto Yagi, Kiyozo Morita, Gen Shinohara, Yukihiro Kaneko, Shuichi Yoshitake, et al. Effect of Long-term Administration of Prostaglandin E1 on Morphologic Changes in Ductus Arteriosus. The Annals of Thoracic Surgery. 2020. 110. 6. 2088-2095
Kazuhiro Kuga, Yoichiro Kusakari, Ken Uesugi, Kentaro Semba, Takashi Urashima, Toru Akaike, Susumu Minamisawa. Fibrosis growth factor 23 is a promoting factor for cardiac fibrosis in the presence of transforming growth factor-β1. PLOS ONE. 2020. 15. 4. e0231905-e0231905

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MISC (155)：

馬場, 俊輔, 赤池, 徹, 暮地本, 宙生, 新庄, 聡子, 南沢, 享, 大石, 公彦, ババ, シュンスケ, アカイケ, トオル, ボチモト, ヒロアキ, シンジョウ, サトコ, et al. 心房特異的Pitx2c過剰発現はカルシウム調節異常により上室不整脈を増加させる (第138回成医会総会一般演題)-Atrial cardiomyocyte-specific Pitx2c overexpression increases atrial arrhythmias through altered calcium regulation. 東京慈恵会医科大学雑誌. 2021. 136. 6. 141-142
BABA Shunsuke, AKAIKE Toru, SHINJO Satoko, BOCHIMOTO Hiroki, MINAMISAWA Susumu. Atrium-specific Pitx2c Overexpression Impaired Sinus Node Function and Increased Atrial Arrythmias. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
SEYA Daiki, AKAIKE Toru, MINAMISAWA Susumu. Transcriptional profiles of the rat pulmonary vein during a perinatal period. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
YOKOTA Takako, AKAIKE Toru, MINAMISAWA Susumu. The transcription factor Nr4a1 may contribute to anatomical closure of the ductus arteriosus via regulating hyaluronic acid production. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
横田昂子, 赤池徹, 南沢享. 転写因子Nr4a1は酸素応答性に発現が増加し,ラット動脈管の解剖学的閉鎖を促進する可能性がある. 日本小児循環器学会総会・学術集会(Web). 2021. 57th

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Books (1)：

Lectures and oral presentations (52)：

Nr4a1はラット動脈管においてプロスタグランジンE1が誘発する内膜肥厚を抑制した
(第99回日本生理学会大会 2022)
転写因子Nr4a1は酸素応答性に発現が増加し、ラット動脈管の解剖学的閉鎖を促進する可能性がある
(第57回日本小児循環器学会総会・学術総会 2021)
Nr4a1 is Identified as an Oxygen-sensitive Gene in the Ductus Arteriosus
(Experimental Biology 2021 2021)
転写因子Nr4a1はヒアルロン酸産生の制御を介して動脈管の解剖学的閉鎖に寄与している可能性が示唆された
(第98回日本生理学会大会 2021)
酸素感受性に寄与する候補遺伝群がラット動脈管と肺小動脈から同定された
(第97回日本生理学会 2020)

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Education (2)：

2006 - 2009 Yokohama City University Graduate School, Division of Medicine Graduate School of Medicine
1993 - 1999 Toyama Medical and Pharmaceutical University Faculty of Medicine

Professional career (2)：

Work history (15)：

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Committee career (1)：

Awards (3)：

2010/03 - 日本循環器学会小児循環器賞
2008/05 - 4th Congress of Asian Society of Pediatric Research Young Investigators’ Awards
2008/05 - Congress of Asian Society of Pediatric Research Young Investigator's Award

Association Membership(s) (1)：

日本医学教育学会

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