Jumpei Morimoto

モリモトジュンペイ | Jumpei Morimoto

Affiliation and department：

Research field (2)： Pharmaceuticals - chemistry and drug development , Biochemistry

Research keywords (5)： Chemical biology , Biofunctional Chemistry , Foldamer , Peptoid , Peptide

Research theme for competitive and other funds (7)：

2023 - 2027 創薬応用可能な人工中分子創出へ向けたペプトイドの代謝研究
2021 - 2025 Construction of fine organic structures via arrangement of subnanometer organic blocks
2019 - 2023 Molecular design of real proteins in virtual space
2019 - 2022 Development of a drug discovery platform targeting intracellular protein-protein interactions based on peptoid
2019 - 2021 Research on synthetic oligomer, peptoid, that realizes selective biomolecular recognition

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Papers (30)：

Kiyofumi Takaba, Saori Maki-Yonekura, Ichiro Inoue, Kensuke Tono, Yasuhiro Fukuda, Yota Shiratori, Yiying Peng, Jumpei Morimoto, Satoru Inoue, Toshiki Higashino, et al. Comprehensive Application of XFEL Microcrystallography for Challenging Targets in Various Organic Compounds. Journal of the American Chemical Society. 2024. 146. 9. 5872-5882
Marin Yokomine, Jumpei Morimoto, Yasuhiro Fukuda, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Hideo Ago, Hiroaki Matsuura, Go Ueno, Akinobu Senoo, et al. A High-Resolution Structural Characterization and Physicochemical Study of How a Peptoid Binds to an Oncoprotein MDM2. Chemical Science. 2024
Jumpei Morimoto, Yota Shiratori, Marin Yokomine, Takumi Ueda, Takayuki Nakamuro, Kiyofumi Takaba, Saori Maki-Yonekura, Koji Umezawa, Koichiro Miyanishi, Yasuhiro Fukuda, et al. Bottom-up design of peptide nanoshapes in water using oligomers of N-methyl-L/D-alanine. 2023
Yuki Hosono, Satoshi Uchida, Moe Shinkai, Chad E Townsend, Colin N Kelly, Matthew R Naylor, Hsiau-Wei Lee, Kayoko Kanamitsu, Mayumi Ishii, Ryosuke Ueki, et al. Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides. Nature communications. 2023. 14. 1. 1416-1416
Takahiro Ono, Kazuhito V Tabata, Hiroyuki Noji, Jumpei Morimoto, Shinsuke Sando. Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers. RSC advances. 2023. 13. 12. 8394-8397

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MISC (1)：

HAYASHI Yuuki, MORIMOTO Jumpei, SUGA Hiroaki. The Explorement of the Specificity of the Akt2 Peptide Inhibitors Selected by a Novel In Vitro Selection Method, RaPID System. 2012. 2011. 91-92

Books (2)：

Lectures and oral presentations (12)：

Oligo(N-methylalanine) as a functionalizable and reprogrammable molecular scaffold for interruption of protein-protein interaction
(2023 SNU-UTokyo Joint Symposium on Chemical Engineering 2023)
細胞内PPI阻害のための人工中分子ペプトイドの設計
(ABC-InFO 2023)
Rational Design of Inhibitors Against an Intracellular Protein-Protein Interaction Based on Conformationally Constrained Peptoids
(ELSI seminar 2023)
膜透過性中分子ペプトイドを用いたタンパク質分子認識への取り組み
(第5回 ACE meeting 2023)
Conformational control of peptoids and its application for protein ligand design
(20 th Japan Scripps Society-East Division Meeting (2022) 2022)

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Education (1)：

2009 - 2012 The University of Tokyo The Graduate School of Engineering Department of Chemistry and Biotechnology

Work history (6)：

2020/05 - 現在 The University of Tokyo The Graduate School of Engineering Department of Chemistry and Biotechnology Lecturer
2021/10 - 2022/03 JST さきがけ研究員(兼任)
2015/03 - 2020/05 The University of Tokyo Graduate School of Enginnering Assistant Professor
2013/04 - 2015/03 The Scripps Research Institute Department of Chemistry JSPS Overseas Research Fellow
2012/04 - 2013/03 The Scripps Research Institute Department of Chemistry Research Associate

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Awards (4)：

2021/10 - The Japanese Peptide Society Award for Young Investigator Conformational studies of alanyl-backbone peptoids and application to biomolecular recognition
2021/03 - The Chemical Society of Japan Young Scholar Lecture Development of synthetic oligoamides with predictable shapes and application of the oligomers for manipulating biomolecules
2019/09 - The Chemical Society of Japan Presentation Award
2018/03 - The Chemical Society of Japan CSJ Presentation Award 2018 Design and Synthesis of Conformationally Constrained β-Peptoids with Chiral Backbone Substituents and Macrocyclization

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