Research field (4)：
Genomics
, Cell biology
, Laboratory animal science
, Molecular biology
Research keywords (3)：
人工染色体
, 細胞医薬
, 実験動物
Research theme for competitive and other funds (2)：
2022 - 2025 人工染色体ベクターを用いた毛細血管拡張性運動失調症の遺伝子治療
2016 - 2019 Development of a novel rat artificial chromosome vector that can be used for human model rat.
Papers (46)：
Hitomaru Miyamoto, Hiroaki Kobayashi, Nanami Kishima, Kyotaro Yamazaki, Shusei Hamamichi, Narumi Uno, Satoshi Abe, Yosuke Hiramuki, Kanako Kazuki, Kazuma Tomizuka, et al. Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation. Nucleic acids research. 2024
Masahito Watanabe, Hitomaru Miyamoto, Kazutoshi Okamoto, Kazuaki Nakano, Hitomi Matsunari, Kanako Kazuki, Koki Hasegawa, Ayuko Uchikura, Shuko Takayanagi, Kazuhiro Umeyama, et al. Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene. Molecular therapy. Nucleic acids. 2023. 33. 444-453
Yosuke Hiramuki, Satoshi Abe, Narumi Uno, Kanako Kazuki, Shuta Takata, Hitomaru Miyamoto, Haruka Takayama, Kayoko Morimoto, Shoko Takehara, Mitsuhiko Osaki, et al. Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model. Scientific Reports. 2023. 13. 1
Kaoru Kobayashi, Tsuneo Deguchi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Atsushi Kurihara, Mitsuo Oshimura, Yasuhiro Kazuki. Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes. Pharmacology research & perspectives. 2022. 10. 6. e01030
Hiroyuki Satofuka, Satoshi Abe, Takashi Moriwaki, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Kyotaro Yamazaki, Genki Hichiwa, Kayoko Morimoto, Haruka Takayama, et al. Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci. Nature Communications. 2022. 13. 1
湯野怜香, 岸間菜々美, 森脇崇史, 宇野愛海, 香月加奈子, 中川和奏, 鈴木輝彦, 冨塚一磨, 香月康宏, 香月康宏, et al. Application of chromosome engineering technology (10): Development of a bottom-up approach to generate mice that retain the BAC-linked HLA gene region. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
尾崎晴加, 峰岸元気, 阿部智志, 阿部智志, 香月加奈子, 香月加奈子, 宮嶋篤志, 小林カオル, 香月康宏, 香月康宏. Inductiion of UGT1A in intestine of UGT1/2 humaized mice. 日本薬学会年会要旨集(Web). 2023. 143rd
峰岸元気, 阿部智志, 阿部智志, 香月加奈子, 香月加奈子, 梶谷尚世, 梶谷尚世, 宮嶋篤志, 小林カオル, 香月康宏, et al. Function of human CYP3A and P-gp in dual humanized mice in vivo. 日本薬学会年会要旨集(Web). 2023. 143rd
増子皓太, 阿部智志, 阿部智志, 香月加奈子, 香月加奈子, 梶谷尚世, 梶谷尚世, 峰岸元気, 宮嶋篤志, 小林カオル, et al. Expression of CYP3A4 and MDR1 in the small intestine of CYP3A/MDR1-humanized mice. 日本薬学会年会要旨集(Web). 2023. 143rd
