Inoue Daichi

イノウエダイチ | Inoue Daichi

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.fbri-kobe.org/laboratory/research5/ , https://www.fbri-kobe.org/english/laboratory/research5/

Research field (4)： Tumor biology , Genetics , Medical biochemistry , Hematology and oncology

Research keywords (13)：がん代謝 , シングルセル解析 , CRISPRスクリーニング , がん , Acute Myeloid Leukemia , Myelodysplastic syndrome , 転写後制御 , Splicing , Epigenetics , マイナーイントロン , エキソソーム , フェロトーシス , 多細胞システム

Research theme for competitive and other funds (15)：

2023 - 2029 DNAイベントレコーダー細胞
2023 - 2028 転写後制御機構の観点からみる造血異常と治療応用
2023 - 2027 Cancer immune therapeutics targeting aberrant RNA splicing products
2023 - 2026 転写産物のロングリード・シーケンスによる食道癌化学放射線療法抵抗性獲得機構の解明
2023 - 2026 レドックスおよびクロマチン制御を標的とした予後不良白血病の新規治療戦略の開発

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Papers (80)：

Koutarou Nishimura, Wataru Saika, Daichi Inoue. Minor introns impact on hematopoietic malignancies. Experimental hematology. 2024. 132. 104173-104173
Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro, et al. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state. Nature communications. 2023. 14. 1. 8372-8372
Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X. Lu, Robert F. Stanley, et al. Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia. Nature Cancer. 2023
Atsushi Tanaka, Koutarou Nishimura, Wataru Saika, Ayana Kon, Yui Koike, Hiromi Tatsumi, June Takeda, Masaki Nomura, Weijia Zang, Manabu Nakayama, et al. SETBP1 is dispensable for normal and malignant hematopoiesis. Leukemia. 2023
Yasutaka Hayashi, Koutarou Nishimura, Atsushi Tanaka, Daichi Inoue. Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies. International journal of hematology. 2023

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MISC (22)：

Yasutaka Hayashi, Kimihito Cojin Kawabata, Yosuke Tanaka, Yasufumi Uehara, Shigeru Kiryu, Yasunori Ota, Yusuke Yoshioka, Yo Mabuchi, Tatsuki Sugiyama, Keiko Mikami, et al. Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS. BLOOD. 2020. 136
Akihide Yoshimi, Kuan-Ting Lin, PhD, Daniel Wiseman, MB, ChB, Andrew M Intlekofer, MD PhD, Bo Wang, Alessandro Pastore, MD, Mohammad Rahman, Stanley Chun-Wei Lee, PhD, et al. Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis. BLOOD. 2017. 130. 1. 473
Stanley Chun-Wei Lee, Khrystyna Dilai, Esther A. Obeng, Eunhee Kim, Jean-Baptiste Micol, Akihide Yoshimi, Christophe Willekens, Daichi Inoue, Veronique Saada, Hana Cho, et al. Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity. BLOOD. 2016. 128. 22
Reim Nagase, Daichi Inoue, Makoto Saika, Hsin-An Hou, Wen-Chien Chou, Kimihito Kawabata, Hironori Harada, Akinori Kanai, Susumu Goyama, Hiroaki Honda, et al. ANALYSIS OF MDS MICE MODEL INDUCED BY ASXL1 AND RUNX1 MUTANTS. EXPERIMENTAL HEMATOLOGY. 2016. 44. 9. S90-S90
Kimihito Cojin Kawabata, Yasutaka Hayashi, Daichi Inoue, Hiroki Mizuno, Jiro Kitaura, Yosuke Tanaka, Susumu Goyama, Yuka Harada, Hironori Harada, Hiroyuki Aburatani, et al. HIGHER EXPRESSION OF ATP-BINDING CASSETTE TRANSPORTER G2 (ABCG2) IS SPECIFIC TO ADVANCED MDS AND PROMOTES INEFFICIENT HEMATOPIESIS VIA CONVERSIONS OF TUMOR MICROENVIRONMENTS IN MOUSE BONE MARROW TRANSPLANTATION MODEL. EXPERIMENTAL HEMATOLOGY. 2016. 44. 9. S110-S110

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Education (2)：

2010 - 2014 The University of Tokyo Graduate School of Medicine
1999 - 2005 Kyoto University Faculty of Medicine Department of Medical Science

Professional career (1)：

博士(医学) (東京大学大学院医学研究科)

Work history (11)：

2024/04 - 大阪大学大学院医学研究科病理学講座(がん病理学) 教授
2024/04 - 大阪大学大学院生命機能研究科教授
2021/10 - Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe Professor
2019/02 - 2021/09 神戸医療産業都市推進機構先端医療研究センター血液・腫瘍研究部グループリーダー
2020/04 - 京都大学大学院医学研究科客員准教授

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Awards (24)：

2023/09 - 日本癌学会 JCA-Mauvernay Award
2022/05 - United Japanese Researchers Around The World UJA論文賞がん部門優秀賞
2022/02 - 井上科学振興財団井上リサーチアウォード
2021/11 - MSD生命科学財団医学奨励賞2021(がん領域)最優秀賞
2021/07 - 麒麟塾麒麟児賞

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Association Membership(s) (6)：

JAPAN SOCIETY OF CLINICAL ONCOLOGY , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , 日本がん分子標的治療学会 , 米国American Association for Cancer Research , 米国血液学会

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