Keiichi Koshizuka

コシヅカケイイチ | Keiichi Koshizuka

Affiliation and department：

Research field (3)： Otorhinolaryngology , Tumor biology , Genomics

Research keywords (6)：頭頸部外科学 , head and neck squamous cell carcinoma , Ferroptosis , HER3 inhibition , PI3K/mTOR , microRNA

Research theme for competitive and other funds (6)：

2022 - 2024 PI3K/mTORシグナル伝達系のゲノム変化を起点とした頭頸部癌新規治療法の開発
2021 - 2022 PI3K-mTORシグナル伝達ネットワークにおけるゲノム変化が抗HER3感受性および抗HER3抵抗性に及ぼす影響の解明
2021 - 2022 PI3K/mTOR経路を基にした頭頸部癌新規治療法開発
2018 - 2020 頭頸部癌患者エクソソーム由来機能性RNA解析に基づく治療抵抗性分子機序の探索
2016 - 2018 Elucidation of extracellular matrix molecular pathway regulated by metastasis-suppressing microRNAs in prostate cancer.

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Papers (45)：

Xingyu Wu, Sendi Rafael Adame-Garcia, Keiichi Koshizuka, Pham Thuy Tien Vo, Thomas S Hoang, Kuniaki Sato, Hiroki Izumi, Yusuke Goto, Michael M Allevato, Kris C Wood, et al. Oncogenic H-RAS induces metformin resistance in head and neck cancer by promoting glycolytic metabolism. Cancer prevention research (Philadelphia, Pa.). 2024
Michael M. Allevato, Sally Trinh, Keiichi Koshizuka, Daniela Nachmanson, Thien-Tu C. Nguyen, Yumi Yokoyama, Xingyu Wu, Allen Andres, Zhiyong Wang, Jeramie Watrous, et al. A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death. Cancer Letters. 2024. 598. 217089-217089
Yusuke Goto, Keiichi Koshizuka, Toshinori Ando, Hiroki Izumi, Xingyu Wu, Kuniaki Sato, Tomohiko Ishikawa, Kyle Ford, Xiaodong Feng, Zhiyong Wang, et al. A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC. Cancer research communications. 2024
関能彩圭, 越塚慶一, 新井亮, 鈴木猛司, 米倉修二, 花澤豊行. 喉頭気管分離術後に発症した気管軟化症例. 耳鼻咽喉科臨床. 2023. 116. 7. 685-690
Alison E Smith, Stacia Chan, Zhiyong Wang, Asako McCloskey, Quinn Reilly, Jayden Z Wang, Hetika Vora Patel, Keiichi Koshizuka, Harris S Soifer, Linda Kessler, et al. Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity. Cancer research. 2023

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MISC (36)：

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Lectures and oral presentations (13)：

Genome-wide CRISPR screening reveals a central role for ferroptotic cell death in the anti-tumor response to mTOR inhibitors in HNSCC
(AACR annual meeting 2024 2024)
microRNA-99a-3pが制御する頭頸部扁平上皮癌・癌分子ネットワークの探索
(第44回日本頭頸部癌学会 2020)
当科における再発頭頸部癌に対するNivolumabの使用経験
(第30回日本頭頸部外科学会 2020)
当科において有利再建手術を行った高齢者頭頸部癌患者の検討
(第43回日本頭頸部癌学会 2019)
頭頸部扁平上皮癌におけるマイクロRNA解析
(第93回日耳鼻千葉県地方部会学術講演会 2018)

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Education (2)：

2014 - 2018 千葉大学大学院医学研究院
2004 - 2010 Chiba University School of Medicine

Professional career (1)：

博士 (千葉大学大学院)

Work history (9)：

2024/09 - 現在 Chiba University Department of Otorhinolaryngology/Head and neck surgery Assistant Professor
2022/09 - 2024/08 Japan Society for the Promotion of Science Overseas Research Fellowships
2021/09 - 2024/08 University of California, San Diego Moores Cancer Center Postdoctoral Scholar
2020/04 - 2021/08 Chiba University Otorhinolaryngology/Head and neck surgery Assistant professor
2018/04 - 2020/03 Chiba University Otorhinolaryngology/Head and neck surgery Medical staff

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Awards (8)：

2021/09 - Mochida Memorial Foundation for Medical and Pharmaceutical Research Study abroad support
2021/08 - Japan Society for the Promotion of Science Overseas Research Fellowships
2020/12 - The Uehara Memorial Foundation Research Fellowship Grants for Study Abroad
2020/07 - 第44回頭頸部癌学会特別企画U40 Session 優秀演題賞
2018/06 - 千葉医学会研究奨励賞

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Association Membership(s) (6)：

THE JAPANESE CANCER ASSOCIATION , JAPAN SOCIETY FOR HEAD AND NECK SURGERY , JAPAN SOCIETY FOR HEAD AND NECK CANCER , THE OTO-RHINO-LARYNGOLOGICAL SOCIETY OF JAPAN , 耳鼻咽喉科臨床学会 , 日本内分泌外科学会

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