Rchr
J-GLOBAL ID：201801013634474369   Update date: Nov. 23, 2024

Yabuki Yasushi

ヤブキ ヤスシ | Yabuki Yasushi
Affiliation and department：
Kumamoto University Institute of Molecular Embryology and Genetics

About Kumamoto University Institute of Molecular Embryology and Genetics


Homepage URL  (1)： http://www.imeg.kumamoto-u.ac.jp/bunya_top/genomic_neurology/staff/
Research field  (5)： Molecular biology ,  Cell biology ,  Neuroscience - general ,  Pharmaceuticals - health and biochemistry ,  Pharmacology
Research keywords  (12)： Neuronal plasticity ,  Psychiatric disorder ,  Neurodegenerative disease ,  グアニン四重鎖 ,  核酸高次構造 ,  α-synuclein ,  プリオン性タンパク質 ,  T-type voltage gated calcium channel ,  learning and memory ,  高次脳機能 ,  Fatty acid binding protein ,  Calcum/calmodulin-dependent protein kinase II
Research theme for competitive and other funds  (26)：
  • 2024 - 2028 Mechanism of neurodegeneration by intranuclear RNA sequestration stress
  • 2024 - 2027 Mechanism of neurodegeneration and axonal dysfunction induced by RNA phase transition
  • 2023 - 2027 G4RNA相分離による神経機能制御メカニズムの解明
  • 2024 - 2026 The establishment of switching on/off system of a non-canonical nucleic acid structure using optogenetics
  • 2023 - 2026 Supramolecular behavior and dynamic capture of meta-aggregates
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Papers (54)：
  • Yasushi Yabuki, Kazuya Matsuo, Ginji Komiya, Kenta Kudo, Karin Hori, Susumu Ikenoshita, Yasushi Kawata, Tomohiro Mizobata, Norifumi Shioda. RNA G-quadruplexes and calcium ions synergistically induce Tau phase transition in vitro. Journal of Biological Chemistry. 2024. 107971-107971
  • Kazuya Matsuo, Sefan Asamitsu, Kohei Maeda, Hiroyoshi Suzuki, Kosuke Kawakubo, Ginji Komiya, Kenta Kudo, Yusuke Sakai, Karin Hori, Susumu Ikenoshita, et al. RNA G-quadruplexes form scaffolds that promote neuropathological α-synuclein aggregation. Cell. 2024
  • Roland Tresky, Yuta Miyamoto, Yu Nagayoshi, Yasushi Yabuki, Kimi Araki, Yukie Takahashi, Yoshihiro Komohara, Huicong Ge, Kayo Nishiguchi, Takaichi Fukuda, et al. TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Nucleic Acids Research. 2024. 52. 15. 9230-9246
  • Kenta Kudo, Karin Hori, Sefan Asamitsu, Kohei Maeda, Yukari Aida, Mei Hokimoto, Kazuya Matsuo, Yasushi Yabuki, Norifumi Shioda. Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with the neurological disorder CANVAS. Journal of Biological Chemistry. 2024. 300. 4. 107138-107138
  • Susumu Ikenoshita, Kazuya Matsuo, Yasushi Yabuki, Kosuke Kawakubo, Sefan Asamitsu, Karin Hori, Shingo Usuki, Yuki Hirose, Toshikazu Bando, Kimi Araki, et al. A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models. The Journal of clinical investigation. 2023
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MISC (30)：
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Education (3)：
  • 2012 - 2015 Tohoku University Graduate School of Pharmaceutical Sciences Division of Bio-Pharmaceutical Science
  • 2010 - 2012 Tohoku University Graduate School of Pharmaceutical Sciences Division of Bio-Pharmaceutical Science
  • 2006 - 2010 Tohoku University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
Professional career (1)：
  • 博士 (薬科学) (東北大学)
Work history (5)：
  • 2023/12 - 現在 Kumamoto University Institute of Molecular Embryology and Genetics Associate Professor
  • 2019/10 - 2023/11 Kumamoto University Institute of Molecular Embryology and Genetics Assistant Professor
  • 2015/04 - 2019/09 Tohoku University Graduate School of Pharmaceutical Sciences Assistant professor
  • 2018/04 - 2019/04 University of Calgary Cumming School of Medicine JSPS Overseas Research Fellowships
  • 2014/04 - 2015/03 Tohoku University Graduate School of Pharmaceutical Sciences Research Fellowship for Young Scientists in Japan Society for the Promotion of Science
Awards (17)：
  • 2024/06 - 日本医学会連合 第3回基礎部会 Rising Starリトリート優秀賞
  • 2024/03 - 第39回日本薬理学会学術奨励賞
  • 2019/12 - 日本薬学会東北支部奨励賞
  • 2019/10 - Excellent Research Award for AsCNP2019
  • 2019/07 - 東北大学大学院薬学研究科長賞
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Association Membership(s) (7)：
The International Society for Neurochemistry ,  Society of Neuroscience ,  JAPAN SOCIETY FOR DEMENTIA RESEARCH ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  THE JAPANESE PHARMACOLOGICAL SOCIETY
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