Rchr
J-GLOBAL ID:201801013705404596   Update date: Sep. 28, 2024

Kawahara Yukio

カワハラ ユキオ | Kawahara Yukio
Affiliation and department:
Job title: 教授
Homepage URL  (1): http://www.med.osaka-u.ac.jp/pub/rna/p_kawahara.html
Research field  (2): Molecular biology ,  Pathobiochemistry
Research keywords  (5): RNA editing/modifications ,  Z-RNA ,  RNA biology ,  amyotrophic lateral sclerosis (ALS) ,  neurodegenerative diseases
Research theme for competitive and other funds  (20):
  • 2024 - 2026 Development of a method to visualize the formation and dynamics of left-handed RNAs in living cells
  • 2023 - 2026 RNA編集不全に起因する自己免疫性脳症発症メカニムズの解明
  • 2022 - 2025 修飾塩基を含むRNAの二次構造解析技術の確立
  • 2020 - 2023 RNA編集酵素ADAR1の脳特異的機能の解明
  • 2019 - 2022 RNA secondary structure prediction using nanopore sequencers
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Papers (53):
  • Kyoka Higuchi, Akiko Uyeda, Lili Quan, Shogo Tanabe, Yuki Kato, Yukio Kawahara, Rieko Muramatsu. Synaptotagmin 4 supports spontaneous axon sprouting after spinal cord injury. The Journal of Neuroscience. 2024. e1593232024
  • Kotaro Miyake, Pedro Henrique Costa Cruz, Izumi Nagatomo, Yuki Kato, Daisuke Motooka, Shingo Satoh, Yuichi Adachi, Yoshito Takeda, Yukio Kawahara, Atsushi Kumanogoh. A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth. Cell Reports. 2023. 42. 7. 112688-112688
  • Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara. RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing. Journal of Biological Chemistry. 2023. 299. 7. 104840-104840
  • Taisuke Nakahama, Yukio Kawahara. The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways. International Immunology. 2022. 35. 3. 123-133
  • Masanori Yoshinaga, Kyuho Han, David W. Morgens, Takuro Horii, Ryosuke Kobayashi, Tatsuaki Tsuruyama, Fabian Hia, Shota Yasukura, Asako Kajiya, Ting Cai, et al. The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity. Nature Communications. 2022. 13. 1. 6435-6435
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MISC (50):
  • N/A. Clinical Neuroscience. 2023. 41. 5. 684-686
  • 中濱泰祐, 河原行郎. The roles of RNA editing in viral infection. 月刊臨床免疫・アレルギー科. 2023. 80. 4
  • Taisuke Nakahama, Yukio Kawahara. Type I interferonopathies caused by dysregulation of RNA metabolism. 2022. 40. 15. 2505-2512
  • Yukio Kawahara. RNA editing: its physiological functions and application to gene modification technology. 2022. 40. 12. 1952-1958
  • Yukio Kawahara. Left-handed RNA as a novel molecular pattern recognized by innate immune system. Clinical Immunology & Allergology. 2022. 78. 1. 111-117
more...
Books (1):
  • Post-transcriptional gene regulation by an Editor: ADAR and its role in RNA Editing.
    Wiley-VCH book 2013 ISBN:9783527322022
Education (2):
  • 2000 - 2004 Graduate School of Medicine, The University of Tokyo PhD student
  • 1989 - 1995 The University of Tokyo Department of Medicine
Professional career (1):
  • 博士(医学) (東京大学)
Work history (6):
  • 2014/04 - 現在 Graduate School of Medicine, Osaka University Department of RNA Biology and Neuroscience Professor
  • 2013/04 - 2014/03 Graduate School of Medicine, Osaka University Laboratory of RNA function Associate Professor
  • 2008/12 - 2013/03 Graduate School of Medicine, Osaka University Laboratory of RNA function Associate Proessor (tenura-track)
  • 2004/06 - 2008/11 The Wistar Institute Nishikura's laboratory Postdoctoral fellow
  • 2004/04 - 2004/05 The University of Tokyo Hospital Department of Neurology JSPS postdoctoral fellow
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Association Membership(s) (8):
The RNA Society ,  The American Association of Immunologists ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  THE RNA SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPAN NEUROSCIENCE SOCIETY ,  JAPANESE SOCIETY OF NEUROLOGY
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