Rchr
J-GLOBAL ID：201801013976025175   Update date: Nov. 08, 2024

Kawashima Shigehiro

カワシマ シゲヒロ | Kawashima Shigehiro
Affiliation and department：
The University of Tokyo

About The University of Tokyo


Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (12)： Phosphorylation ,  Acylation ,  Acetylation ,  Histone ,  Shugoshin ,  Chemical Screening ,  Chemical Genetics ,  Chemical Biology ,  Ribosome Biogenesis ,  Catalysis Medicine ,  Epigenetics ,  Chromosome
Research theme for competitive and other funds  (6)：
  • 2021 - 2025 Development of chemical catalyst enabling epigenome manipulation
  • 2019 - 2023 化学触媒ツールの開発を基軸としたヒストン修飾とDNA修復の相関解明
  • 2018 - 2020 Discovery and analysis of novel small molecules targeting human Midasin proteins
  • 2014 - 2019 Studying molecular mechanisms of centromeric localization of Shugoshin
  • 2016 - 2018 人工触媒システムを用いたヒストンアシル化の機能解析
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Papers (39)：
  • Tomoyuki Fukuta, Toshifumi Tatsumi, Kohei Fujiyoshi, Takashi Koyama, Shigehiro A Kawashima, Harunobu Mitsunuma, Kenzo Yamatsugu, Motomu Kanai. Umpolung Phosphorylation of Tyrosine via 1,2-Phospha-Brook Rearrangement. Organic letters. 2024. 26. 41. 8827-8831
  • Tamiko Nozaki, Mayu Onoda, Misuzu Habazaki, Yuma Takeuchi, Hisashi Ishida, Yuko Sato, Tomoya Kujirai, Kayo Hanada, Kenzo Yamatsugu, Hitoshi Kurumizaka, et al. Logics for Developing Regioselective Histone Acetylating Catalysts. 2024
  • Masahiro Furuta, Suguru Arii, Hiroki Umeda, Ryota Matsukawa, Katsuyuki Shizu, Hironori Kaji, Shigehiro A. Kawashima, Yukiko Hori, Taisuke Tomita, Youhei Sohma, et al. Leuco Ethyl Violet as Self-Activating Prodrug Photocatalyst for In Vivo Amyloid-Selective Oxygenation. Advanced Science. 2024
  • Akiko Fujimura, Hisashi Ishida, Tamiko Nozaki, Shuhei Terada, Yuto Azumaya, Tadashi Ishiguro, Yugo R Kamimura, Tomoya Kujirai, Hitoshi Kurumizaka, Hidetoshi Kono, et al. Designer Adaptor Proteins for Functional Conversion of Peptides to Small-Molecule Ligands toward In-Cell Catalytic Protein Modification. ACS central science. 2023. 9. 11. 2115-2128
  • Haruka Oda, Yuko Sato, Shigehiro A. Kawashima, Yusuke Fujiwara, Máté Pálfy, Edlyn Wu, Nadine L. Vastenhouw, Motomu Kanai, Hiroshi Kimura. Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo. Biology Open. 2023. 12. 5
ｍore...
MISC (1)：
  • Novel function of shugoshin-ensuring bipolar attachments by regulation of Aurora B. Cell technology. 2007. 26. 9. 1054-1058
Education (3)：
  • 2003 - 2008 The University of Tokyo Graduate School of Science Department of Biophysics & Biochemistry
  • 2001 - 2003 The University of Tokyo
  • 1999 - 2001 The University of Tokyo
Professional career (1)：
  • 理学 (東京大学)
Work history (6)：
  • 2022/04 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2021/04 - 2022/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2016/10 - 2021/03 The University of Tokyo Graduate School of Pharmaceutical Sciences Lecturer
  • 2012/09 - 2018/04 The University of Tokyo Graduate School of Pharmaceutical Sciences ERATO project Group Leader
  • 2009/10 - 2012/08 The Rockefeller University Postdoctoral Fellow
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Awards (2)：
  • 2019/04 - 文部科学省 科学技術分野の文部科学大臣表彰 若手科学者賞 エピゲノムを操作する人工化学触媒の開発研究
  • 2010 - Inoue Foundation for Science Inoue Research Award for Young Scientists
Association Membership(s) (5)：
エピジェネティクス研究会 ,  日本癌学会 ,  ケミカルバイオロジー学会 ,  日本薬学会 ,  日本分子生物学会
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