Date Kimie

Affiliation and department：

Research field (7)： Medical biochemistry , Functional biochemistry , Molecular biology , Cell biology , Structural biochemistry , Molecular biochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (10)：膵臓消化酵素 , 機能性食品 , 栄養消化・吸収 , 骨粗鬆症 , 膵臓がん , 糖鎖生物学 , 組織再生 , 細胞外マトリックス , 糖尿病 , 生物化学

Research theme for competitive and other funds (7)：

2018 - 2023 膵α-アミラーゼが認識するインスリン分泌制御糖タンパク質 DPP-4 の糖鎖構造と機能
2019 - 2022 膵臓がんの検出・抑制に向けた, 膵酵素とがん特異糖鎖との相互作用解析
2017 - 2022 食品成分による高血糖抑制機構の解明:腸内機能性糖鎖の制御による健康長寿
2014 - 2017 膵α-アミラーゼの腸内糖鎖リガンドを介する血糖値調節機構の解明とその制御
2013 - 2014 DPP-4との相互作用解析が仲介する膵α-アミラーゼのN-型糖鎖認識の役割

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Papers (24)：

Regulatory properties of vitronectin and its glycosylation in collagen fibril formation and collagen-degrading enzyme cathepsin K activity. 2021
Kimie Date. Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation. New Insights Into Metabolic Syndrome [Working Title]. 2020
Kimie Date, Tomomi Yamazaki, Yoko Toyoda, Kumi Hoshi, Haruko Ogawa. α-Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation. Journal of Cellular Biochemistry. 2020. 121. 2. 1238-1249
Kimie Date, Fumie Kano-Yajima, Kosuke Nakamura, Takahiro Ohtsuki, Hiroo Hoshino, Ken-ichi Tanamoto, Hiroshi Ushijima, Hiromi Sakagami, Haruko Ogawa. Vitronectins produced by human cirrhotic liver and CCl4-treated rats differ in their glycosylation pattern and tissue remodeling activity. FEBS openbio. 2019. https://doi.org/10.1002/2211-5. open access article. 755-768
Nanami Kawaguchi, Haruko Ogawa, Kimie Date. Preparation and Purification of Active Recombinant Human Pancreatic Lipase in Escherichia coli. BIO-PROTOCOL. 2019. 9. 13

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MISC (5)：

日比野明日香, 緒方彩, 和田有沙, 伊達公恵, 藤間祥子, 舘野浩章, 小川温子, 小川温子. 膵トリプシン・トリプシノーゲンに見出したグリコサミノグリカン結合性. 日本糖質学会年会要旨集. 2019. 38th
Kimie Date, Ayano Satoh, Haruko Ogawa. Pancreatic alpha-amylase controls glucose assimilation in duodenum through N-glycan-specific binding, followed by endocytosis and degradation. GLYCOBIOLOGY. 2014. 24. 11. 1185-1185
Haruko Ogawa, Kotone Sano, Naomi Sobukawa, Kimie Asanuma-Date. New Approach to Detect Changes in Sialylation of the Matrix Glycoprotein Vitronectin, which Regulates Matrix Restructuring During Liver Regeneration. GLYCOBIOLOGY. 2012. 22. 11. 1568-1568
Kimie Date, Nana Kawasaki, Noritaka Hashii, Hiromi Sakagami, Haruko Ogawa. Carbohydrate-specific interaction of mammalian pancreatic alpha-amylases with glycoproteins on intestinal mucosa regulates glucose as similation for homeostasis. GLYCOBIOLOGY. 2012. 22. 11. 1540-1540
佐野琴音, 宮本泰則, 川崎ナナ, 橋井則貴, 伊藤さつき, 村瀬美咲, 伊達公恵, 横山三紀, 佐藤ちひろ, 佐藤ちひろ, et al. 肝再生時ラットビトロネクチンの部位特異的糖鎖修飾と組織再生を担う肝星細胞接着伸展に与える影響. 生化学. 2010. 82. 9

Books (3)：

細胞外マトリックス分子の糖鎖による肝再生の制御
化学工業 Volume61, No.12 2010
O-Linked Glycosylation on Focus
2000
Dynamic Cytoskeletal Glycosylation and Neurodegenerative Disease
1999

Education (3)：

2008 - 2012 Ochanomizu University
2000 - 2002 Ochanomizu University
1996 - 2000 Ochanomizu University Faculty of Science Division of Chemistry

Professional career (1)：

博士(理学) (お茶の水女子大学)

Work history (8)：

2021/04 - 現在 Ochanomizu University Institute for Human Life Innovation
2017/04 - Ochanomizu University Institute for Human Life Innovation
2015/10 - 2016/10 イェール大学医学部リサーチフェロー
2014/04 - Ochanomizu University
2012/04 - Ochanomizu University

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Awards (5)：

2017/02 - 公益財団法人ロッテ財団ロッテ重光学術賞食品成分による高血糖抑制機構の解明:腸内機能性糖鎖の制御による健康長寿
2016/10 - Poster of Distinction, Renalase forms high molecular weight complex in plasma for tissue translocation in acute pancreatitis.
2014/11 - 2014 Joint Meeting of SFG & Japanese Society of Carbohydrates (JSCR) Society for Glycobiology (SFG) Travel Award, Pancreatic α-amylase controls glucose assimilation in duodenum through N-glycan-specific binding, followed by endocytosis and degradation
2012/12 - 85回日本生化学会大会鈴木紘一メモリアル賞 (優秀プレゼンテーション賞) 膵α-アミラーゼと腸内糖鎖リガンドとの結合を介する糖吸収調節機構の発見
2010/11 - お茶の水女子大学保井・黒田奨学金生体内における糖鎖機能の生化学的解明-組織再生ならびに代謝調節-

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