2017 - 2020 Novel role of SIRT1 in regulation of autophagy and its role in heart failure
2010 - 2012 Functional roles of SIRT1 in the differentiation of neural cells
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Papers (81):
Ryuta Nakashima, Ryusuke Hosoda, Yuki Tatekoshi, Naotoshi Iwahara, Yukika Saga, Atsushi Kuno. Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy. Scientific reports. 2024. 14. 1. 1365-1365
Satoshi Katano, Toshiyuki Yano, Hidemichi Kouzu, Ryohei Nagaoka, Ryo Numazawa, Kotaro Yamano, Yusuke Fujisawa, Katsuhiko Ohori, Nobutaka Nagano, Takefumi Fujito, et al. Circulating level of β-aminoisobutyric acid (BAIBA), a novel myokine-like molecule, is inversely associated with fat mass in patients with heart failure. Heart and Vessels. 2023
Ryusuke Hosoda, Ryuta Nakashima, Masaki Yano, Naotoshi Iwahara, Seidai Asakura, Iyori Nojima, Yukika Saga, Risa Kunimoto, Yoshiyuki Horio, Atsushi Kuno. Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice. Journal of Pharmacological Sciences. 2023
Arata Osanami, Tatsuya Sato, Yuki Toda, Masaki Shimizu, Atsushi Kuno, Hidemichi Kouzu, Toshiyuki Yano, Wataru Ohwada, Toshifumi Ogawa, Tetsuji Miura, et al. Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca2+ overload in type 2 diabetes rat hearts. Journal of diabetes investigation. 2023
Toshifumi Ogawa, Hidemichi Kouzu, Arata Osanami, Yuki Tatekoshi, Tatsuya Sato, Atsushi Kuno, Yugo Fujita, Shoya Ino, Masaki Shimizu, Yuki Toda, et al. Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts. Physiological Reports. 2023. 11. 4. e15608
Sirt1 Activation Restores Mitophagy-Mediated Clearance of Damaged Mitochondria and Ameliorates Dystrophic Cardiomyopathy in Mice
(米国心臓協会学術集会2018 2018)
Resveratrol, a SIRT1 activator, restores autophagy-mediated clearance of damaged mitochondria and ameliorates dystrophic cardiomyopathy in mice.
(第22回 日本心不全学会学術集会 2018)
国際心臓研究学会
, 米国心臓協会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE PHARMACOLOGICAL SOCIETY
, The Japanese Circulation Society
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE