TAKESHI HARAGUCHI

ハラグチタケシ | TAKESHI HARAGUCHI

Affiliation and department：
Job title： Research Associate Professor

Research field (1)： Molecular biology

Research theme for competitive and other funds (9)：

2020 - 2023 腫瘍組織におけるmicroRNA阻害を可能とするペプチドリガンド搭載LNPの開発
2019 - 2020 核酸医薬を用いたmiR-21の阻害による膵臓がん治療法の開発
2017 - 2020 Regulatory mechanisms involved in SRF-MKL1/2 complex in epithelial tumors
2014 - 2017 Search for miRNAs that regulate stemness of breast cancer stem cell to find therapeutic targets of triple-negative breast cancer.
2011 - 2013 複数種類miRNAの強制発現及び機能阻害による人工癌幹細胞作製法の開発

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Papers (21)：

Hiramatsu H, Kobayashi K, Kobayashi K, Haraguchi T, Ino Y, Todo T, Iba H. Author Correction: The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells. Scientific reports. 2018. 8. 1. 16079
Kazuyoshi Kobayashi, Hiroaki Hiramatsu, Shinya Nakamura, Kyousuke Kobayashi, Takeshi Haraguchi, Hideo Iba. Tumor suppression via inhibition of SWI/SNF complex-dependent NF-kappa B activation. SCIENTIFIC REPORTS. 2017. 7. 1. 11772
Kyousuke Kobayashi, Fumiko Suemasa, Hiroshi Sagara, Shinya Nakamura, Yasushi Ino, Kazuyoshi Kobayashi, Hiroaki Hiramatsu, Takeshi Haraguchi, Kazuo Kurokawa, Tomoki Todo, et al. MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus. SCIENTIFIC REPORTS. 2017. 7. 1. 6650
Hiroaki Hiramatsu, Kazuyoshi Kobayashi, Kyousuke Kobayashi, Takeshi Haraguchi, Yasushi Ino, Tomoki Todo, Hideo Iba. The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells. SCIENTIFIC REPORTS. 2017. 7. 1. 889
Takeshi Haraguchi, Masayuki Kondo, Ryo Uchikawa, Kazuyoshi Kobayashi, Hiroaki Hiramatsu, Kyousuke Kobayashi, Ung Weng Chit, Takanobu Shimizu, Hideo Iba. Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition. SCIENTIFIC REPORTS. 2016. 6. 21117

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MISC (9)：

Hiroaki Hiramatsu, Kazuyoshi Kobayashi, Takeshi Haraguchi, Yasushi Ino, Tomoki Todo, Hideo Iba. The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells. CANCER SCIENCE. 2018. 109. 879-879
Kazuyoshi Kobayashi, Hiroaki Hiramatsu, Takeshi Haraguchi, Hideo Iba. Inhibition of SWI/SNF complex-dependent NF-kappa B activation suppresses tumor formation. CANCER SCIENCE. 2018. 109. 885-885
Functional analysis of miRNA by using Tough Decoy (TuD) RNA expression vectors. 2010. 61. 4. 326-331
櫻井浩平, 原口健, 田川嵩展, 上野義仁, 小縣綾, 伊庭英夫. ヒトがん細胞株において,エピジェネティクスに重要な因子であるBrmは,miR-199a-5p,-3pとダブルネガティブフィードバックループを形成する. 生化学. 2010
原口健, 櫻井浩平, 伊庭英夫. 特定のmiRNAを阻害するTuD RNAの有用性. 生体の科学. 2010. 61. 4

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Patents (5)：

Lectures and oral presentations (3)：

microRNA研究を加速させる高効率microRNA阻害法-TuD RNA発現ベクターとS-TuD-
(第72回日本癌学会学術総会ランチョンセミナー 2013)
独自の二次構造を持つ2’-OME RNAオリゴを基盤としたmicroRNA阻害剤「S-TuD」
(第12回分子複合医薬研究会 2012)
独自の二次構造を持つ2’-OME RNAオリゴ新規microRNA阻害剤「S-TuD」
(第28回日本DDS学会学術集会 2012)

Education (3)：

Professional career (1)：

Work history (4)：

2019/08 - 現在 Chiba University MMRC/RNA Therapy Research Associate Professor
2016/04 - 2019/07 Chiba University Research Center for Pathogenic Fungi and Microbial Toxicoses
2009/04 - 2016/03 The University of Tokyo The Institute of Medical Science, Division of Host-Parasite Interaction
2006/04 - 2009/03 学術振興会特別研究員(DC1)

Awards (1)：

Association Membership(s) (3)：

核酸医薬学会 , THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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