Mizuno Yuki

ミズノユウキ | Mizuno Yuki

Affiliation and department：
Job title：助教

Research field (2)： Radiology , Pharmaceuticals - analytical and physicochemistry

Research keywords (3)：ペプチド , 多価効果 , 放射性医薬品

Research theme for competitive and other funds (11)：

2022 - 2027 多価効果と代謝性リンカーの融合による革新的核医学治療薬の開発
2022 - 2025 セラノスティクスを目的とした放射性標識ソマトスタチンアナログの体内動態の最適化
2022 - 2025 血管新生因子PD-ECGFを標的としたAt-211標識治療用放射性薬剤の基礎検討
2021 - 2025 PET imaging for cancer treatment inducing ferrotosis
2021 - 2024 Ferroptosis imaging with PET: Challenge to assess vulnerability of atherosclerotic plaques

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Papers (12)：

Kazuhiro Kato, Hironobu Yasui, Hideo Sato-Akaba, Miho C Emoto, Hirotada G Fujii, Maciej M Kmiec, Periannan Kuppusamy, Yuki Mizuno, Yuji Kuge, Masaki Nagane, et al. Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor. Free radical biology & medicine. 2024
Tetsuro Tada, Yuki Mizuno, Yuki Shibata, Hironobu Yasui, Yuji Kuge. Application of copper (I) selective ligands for PET imaging of reactive oxygen species through metabolic trapping. Nuclear Medicine and Biology. 2024. 108914-108914
Yutaka Morishima, Masahito Kawabori, Kazuyoshi Yamazaki, Soichiro Takamiya, Sho Yamaguchi, Yo Nakahara, Hajime Senjo, Daigo Hashimoto, Sakiko Masuda, Yoichiro Fujioka, et al. Intravenous Administration of Mesenchymal Stem Cell-Derived Exosome Alleviates Spinal Cord Injury by Regulating Neutrophil Extracellular Trap Formation through Exosomal miR-125a-3p. International journal of molecular sciences. 2024. 25. 4
Soichiro Takamiya, Masahito Kawabori, Tsukasa Kitahashi, Kentaro Nakamura, Yuki Mizuno, Hironobu Yasui, Yuji Kuge, Aki Tanimori, Yasuyuki Takamatsu, Kohei Yuyama, et al. Intracerebral Transplantation of Mesenchymal Stromal Cell Compounded with Recombinant Peptide Scaffold against Chronic Intracerebral Hemorrhage Model. Stem Cells International. 2022. 2022. 1-10
Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri, Yuji Kuge, Hiromichi Akizawa. Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αvβ3. Journal of Medicinal Chemistry. 2021

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MISC (6)：

Sho Tomita, Kei Higashikawa, Yuki Mizuno, Tetsuroh Tada, Shusaku Tazawa, Yuji Kuge. Long-Term Radiation Safety Evaluation of ⁶⁸Ge/⁶⁸Ga Generator. RADIOISOTOPES. 2022. 71. 1. 1-8
富田翔, 東川桂, 上野悟史, 水野雄貴, 田沢周作, 久下裕司. ⁶⁸Ge/⁶⁸Ga ジェネレータの長期間の品質検査. 核医学. 2021. 58. 1. 47-58
MIZUNO Yuki, Akizawa Hiromichi. Theranostics in Nuclear Medicine Practice. 2019. 11. 505-509
Y. Mizuno, N. Komatsu, T. Uehara, H. Akizawa, Y. Arano. Synthesis and evaluation of a ^99mTc-labeled hexavalent targeting probe from a monovalent ligand for in vivo imaging of saturable systems. Nuclear Medicine and Biology. 2019. 72-73. S3-S3
Mizuno Yuki, Jen Chun-wei, Hanaoka Hirofumi, Uehara Tomoya, Arano Yasushi. Design of a Trivalent Tc-99m-Probe for High Avidity Receptor Targeting and Enhanced Target Uptake. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2015. 58. S119

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Lectures and oral presentations (30)：

複数のintegrin αvβ3と同時結合可能な多価cRGDペプチドの開発と多様な放射性同位元素で標識可能な構造への展開
(第6回日本核医学会分科会放射性薬品科学研究会/第22回放射性医薬品・画像診断薬研究会 2023)
複数のintegrin αvβ3と同時結合可能な多価cRGDの化学構造:複数の細胞株を用いた検討
(バイオメディカル分析科学シンポジウム 2023)
18F-FDG PET/MRI によるマウス網膜変性疾患モデルの評価
(第17回分子イメージング学会総会・学術集会 2023)
Synthesis of [64Cu]Cu+ complex for redox imaging and evaluation of its reactivity with reactive oxygen species
(The 25th International Symposium of Radiopharmaceutical Sciences (iSRS 2023) 2023)
The synthesis and evaluation of [68Ga]Ga-HBED-CC-TfRB1G3 for TfR1 imaging
(The 25th International Symposium of Radiopharmaceutical Sciences (iSRS 2023) 2023)

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Education (3)：

2014 - 2017 千葉大学大学院医学薬学府先端創薬科学専攻博士課程
2012 - 2014 千葉大学大学院医学薬学府総合薬品科学専攻修士課程
2008 - 2012 Chiba University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士 (薬科学) (千葉大学)

Work history (3)：

2020/04 - 現在 Hokkaido University Central Institute of Isotope Science
2017/04 - 2020/03 Showa Pharmaceutical University
2014/04 - 2017/03 日本学術振興会特別研究員

Awards (4)：

2023/09 - 第6回放射性薬品科学研究会若手研究者部門優秀発表賞複数のintegrin αvβ3と同時結合可能な多価cRGDペプチドの開発と多様な放射性同位元素で標識可能な構造への展開
2015/03 - 日本薬学会日本薬学会第135年会優秀発表賞
2014/05 - 日本分子イメージング学会最優秀発表賞
2012/08 - 物理系薬学部会若手研究者奨励賞

Association Membership(s) (3)：

日本分子イメージング学会 , JAPANESE SOCIETY OF NUCLEAR MEDICINE , THE PHARMACEUTICAL SOCIETY OF JAPAN

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