Akiyama Masashi

アキヤママサシ | Akiyama Masashi

Research field (3)： Structural biochemistry , Hematology and oncology , Molecular biology

Research theme for competitive and other funds (15)：

2022 - 2025 血小板リガンドとSiglecの相互作用による好中球・単球の血栓形成促進機構の解明
2019 - 2022 Regulation of NETs formation by VWF and ADAMTS13 binding to neutrophil Siglecs
2016 - 2019 Clearance mechanism of ADAMTS13
2016 - 2019 Studies on thrombotic risk of protein S K196E mutation
2013 - 2016 Analysis of molecular pathogenesis of thrombosis in Japanese using mice with genetic mutations in anticoagulation/fibrinolytic factors

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Papers (63)：

Masashi Akiyama, Yuka Eura, Koichi Kokame. Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS13. Thrombosis Research. 2022
Shiro Ono, Hideto Matsui, Masashi Noda, Shogo Kasuda, Noritaka Yada, Kiyomi Yoshimoto, Masashi Akiyama, Toshiyuki Miyata, Mitsuhiko Sugimoto, Kenji Nishio. Functional regulation of von Willebrand factor ameliorates acute ischemia-reperfusion kidney injury in mice. Scientific reports. 2019. 9. 1. 14453-14453
Maruyama K, Akiyama M, Miyata T, Kokame K. Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI. Research and practice in thrombosis and haemostasis. 2018. 2. 4. 751-756
Nagaya S, Akiyama M, Murakami M, Sekiya A, Asakura H, Morishita E. Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins. Haemophilia : the official journal of the World Federation of Hemophilia. 2018. 24. 5. 774-785
Yasuyuki Urisono, Asuka Sakata, Hideto Matsui, Shogo Kasuda, Shiro Ono, Kiyomi Yoshimoto, Kenji Nishio, Masayuki Sho, Masashi Akiyama, Toshiyuki Miyata, et al. Von Willebrand Factor Aggravates Hepatic Ischemia-Reperfusion Injury by Promoting Neutrophil Recruitment in Mice. Thrombosis and Haemostasis. 2018. 118. 4. 700-708

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MISC (31)：

秋山正志. 【TTPの基礎と臨床】ADAMTS13活性のアロステリック調節. 日本血栓止血学会誌. 2022. 33. 4. 394-398
秋山正志, 小亀浩市. 【ADAMTS13が関与する多様な病態】ADAMTS13の構造変化と機能発現. Thrombosis Medicine. 2019. 9. 3. 196-205
Shear-induced unfolding and cleavage of VWF by ADAMTS13 : pathophysiology of von Willebrand disease and thrombotic thrombocytopenic purpura. 2017. 89. 3. 343-350
前田琢磨, 秋山正志. 凝固・線溶・血小板タンパク質の機能発現機構 HITの発症を誘導する免疫複合体の構造. 日本血栓止血学会誌. 2016. 27. 6. 678-682
Eriko Morishita, Mao Takata, Fumina Taniguchi, Masashi Akiyama, Akiko Sekiya, Akira Takagi, Toshiyuki Miyata, Tetsuhito Kojima. Asymptomatic Dysprothrombinemia (Prothtombin Himi) with p.M380T and p.R431H Shows Severely Reduced Clotting Activity, Moderate Antithrombin Resistance and Severe Thrombomodulin Binding Defect. BLOOD. 2016. 128. 22

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Patents (1)：

Professional career (1)：

Association Membership(s) (3)：

日本血液学会 , 日本生化学会 , 日本血栓止血学会

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