Research field (4)：
Systems genomics
, Pharmacology
, Molecular biology
, Biophysics
Research keywords (6)：
Circadian rhythm
, Proteomics
, Mathematical modeling
, Sleep wake cycle
, Circadian clocks
, DNA replication
Research theme for competitive and other funds (15)：
2024 - 2029 Chronoproteinnology: CaMKII as an Encoder of Time Information Spanning from Seconds to Minutes
2024 - 2029 chronoproteinology
2023 - 2026 単相性睡眠マウスの設計と応用
2021 - 2024 Chronoproteinology of Sleep homeostasis: Identification and Understanding of Nemuri complex and their physical property
2021 - 2024 Chrono-proteinology: principle and design for protein timers
2018 - 2023 Designing the mammalian biological oscillators
2020 - 2023 リン酸化酵素CaMKIIの自律的長期活性化維持機構の解明
2018 - 2020 新規ATPアナログによるリン酸化経路選択問題へのアプローチ
2018 - 2019 CaMKIIβの長期活性維持機構を担うリン酸化状態の解明とその意義
2016 - 2019 Cerebrospinal Fluid Biomarkers for Lumbar Spinal Stenosis Identified by an Exhaustive search with High-Resolution Mass Spectrometry
2013 - 2018 Understanding the design principle of circadian oscillator in mammals through reconstitution
2016 - 2018 Development of a method for LC-MS analysis for cleared organs Research Project
2011 - 2016 Small-number issues in biological rhythms: regulation of oscillation system with low-abundant proteins through tuning turnover rate
2013 - 2015 Control of mammalian circadian clock through phosphorylation-dependent proteolysis of Cry1
2008 - 2011 染色体複製ライセンス化機構の解析-多要素制御系への実験的アプローチ-
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Papers (45)：
Yimeng Wang, Siyu Cao, Daisuke Tone, Hiroshi Fujishima, Rikuhiro G. Yamada, Rei-ichiro Ohno, Shoi Shi, Kyoko Matsuzawa, Saori Yada, Mari Kaneko, et al. Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles. Nature. 2024
Rikuhiro G. Yamada, Kyoko Matsuzawa, Koji L. Ode, Hiroki R. Ueda. An automated sleep staging tool based on simple statistical features of mice electroencephalography (EEG) and electromyography (EMG) data. European Journal of Neuroscience. 2024. 60. 7. 5467-5486
Kazuhiro Kon, Koji L. Ode, Tomoyuki Mano, Hiroshi Fujishima, Riina R. Takahashi, Daisuke Tone, Chika Shimizu, Shinnosuke Shiono, Saori Yada, Kyoko Matsuzawa, et al. Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation. Nature Communications. 2024. 15. 1. 6054
Yukako Shintani-Domoto, Koji L Ode, Seitaro Nomura, Hiroyuki Abe, Hiroki R Ueda, Takashi Sakatani, Ryuji Ohashi. Correction to: Elucidation of the mechanism of amyloid A and transthyretin formation using mass spectrometry-based absolute quantification. Virchows Archiv : an international journal of pathology. 2023
Yukako Shintani-Domoto, Koji L Ode, Seitaro Nomura, Hiroyuki Abe, Hiroki R Ueda, Takashi Sakatani, Ryuji Ohashi. Elucidation of the mechanism of amyloid A and transthyretin formation using mass spectrometry-based absolute quantification. Virchows Archiv : an international journal of pathology. 2023
Hiroki R. Ueda, Koji L. Ode, Hiroyuki J. Kanaya. Faculty Opinions Recommendation of [Cichon J et al., Nat Neurosci 2023 26(1:39-52)]. Faculty Opinions. 2023
バイエステロッチ マリアネウス, 史蕭逸, 戸根大輔, 大出晃士, 藤島博史, 山田陸裕, 隅山健太, 上田泰己. Investigating roles of pore-loop cation channels for cortical neuronal synchrony and sleep quality and time. 時間生物学. 2023. 29. 2
戸根大輔, 戸根大輔, 大出晃士, 大出晃士, 張千惠, 上田泰己, 上田泰己. Mammalian sleep regulation by phosphorylation states of CaMKII. 日本薬理学雑誌. 2023. 158. Supplement
Koji L Ode, Zhiqing Wen, Hiroki R Ueda. Phosphorylation hypothesis of sleep-wake control. 2022. 40. 11. 1696-1701
2008 - 2011 Osaka University Graduate School of Science Department of Biological Scciences (Ph.D course)
2006 - 2008 Osaka University Graduate School of Science Department of Biological Scciences (Master course)
2002 - 2006 Osaka University School of Science Department of Biology
Professional career (1)：
Ph.D. (Osaka Univ.)
Work history (4)：
2019/12 - 現在 The University of Tokyo Graduate School of Medicine Lecturer
2013/04 - 2019/12 The University of Tokyo Graduate School of Medicine Research Associate
2011/04 - 2013/03 RIKEN Quantitative Biology Center Postdoctoral Researcher
2008/04 - 2011/03 Japan Society for the Promotion of Science Research Fellowship for Young Scientists (DC1)
Awards (4)：
2020/09 - Japanese Society for Chronobiology 日本時間生物学会学術奨励賞
2013/03 - RIKEN Research Incentive Award Theoretical investigation of design principle for an autonomous oscillator driven by enzymatic reactions
2012/05 - Society for Research on Biological Rhythms Research Excellence Award Minimal design of reversible dual phosphorylation oscillator
2006/03 - 大阪大学 楠本賞
Association Membership(s) (6)：
The Japanese Biochemical Society
, THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE MASS SPECTROMETRY SOCIETY OF JAPAN
, THE BIOPHYSICAL SOCIETY OF JAPAN
, JAPANESE SOCIETY FOR CHRONOBIOLOGY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
