Rchr
J-GLOBAL ID：201801014309054503
Update date: May. 17, 2024
Katanosaka Yuki
カタノサカ ユキ | Katanosaka Yuki
Affiliation and department：
Research field (4)：
Biophysics
, Medical systems
, Clinical pharmacy
, Physiology
Research keywords (8)：
メカニカルフィードバック
, メカノトランスダクション
, メカノバイオロジー
, メカニカルストレス
, ストレッチ
, メカノセンサー
, KO mouse
, TRPV2
Research theme for competitive and other funds (37)：
- 2023 - 2026 筋の動けば肥大し、動かなければ痩せるしくみの解明
- 2023 - 2026 Resilience Biology -What are the molecular mechanisms that support the resilience of life?-
- 2022 - 2025 筋血管のメカニカルストレス応答の解明に基づく運動後の筋痛発症と適応機序の理解
- 2021 - 2024 新規メカニカル負荷装置の開発を通した次世代メカノメディスンへの挑戦
- 2021 - 2024 大動脈解離におけるメカノバイオロジー機構の解明
- 2021 - 2024 心血管メカノセンサーTRPV2の低酸素誘発性肺高血圧症への関与解明と治療法開発
- 2020 - 2024 Monitoring of the activity of cardiac mechanosensor
- 2020 - 2023 The role of mechanically-sensitive ion channels in delayed onset muscle soreness
- 2018 - 2022 Elucidation of the mechanisms underlying muscle adaptation to exercise via neuromuscular crosstalk based on biomedical engineering analysis.
- 2019 - 2021 Role of TRPV2 in podocytes
- 2018 - 2021 Understanding of the mechanism of ribitol-phosphate modification and application of its physiological function to therapy
- 2018 - 2020 Identification of mechanical signal from intercalated discs
- 2017 - 2020 Mechanotransduction on cardiac physiology
- 2015 - 2019 生体の機械受容機構の分子基盤と生理的意義の解明による革新的医療ターゲットの確立
- 2015 - 2018 Biomedical engineering-based analysis of the molecular mechanisms underlying functional crosstalk between muscle and neurons.
- 2015 - 2018 Elucidation of structure, modification mechanism, pathophysiological roles of a novel posttranslational modification, post-phosphoryl sugar chain
- 2015 - 2017 Establishment of the way to identify and isolate the heat-sensitive primary sensory neurons for understanding the peripheral mechanisms of heat pain.
- 2014 - 2017 Information control for a linkage between macro cardiac function and gene expression: physiomic analysis of responses to oxygen environment
- 2014 - 2017 The importance of local Ca2+ control beneathe the T-tubule membrane in cardiomyocytes
- 2014 - 2017 Elucidation of molecular mechanism of mechanotransduction in the heart
- 2014 - 2016 The maintenance of cardiac structure and function by mechanical feedback system involving multiple organ systems.
- 2012 - 2015 Investigation of a role for multifunctional mechanosensor TRPV2 in adult sensory neuron and pain
- 2011 - 2014 メカニカルストレスを利用した生体の巧みな適応機構と破綻システムの解明
- 2009 - 2012 マルチレベル医工学評価法に基づく心筋メカノセンサーの作動機序と病態生理的役割
- 2010 - 2012 Elucidation of Biological Adaptation and Remodeling Mechanisms to Mechanical Stress Based on the Development of Novel Micro-Electro-Mechanical Systems (MEMS) technology
- 2010 - 2012 The relationship between actin bundling by dynamin/cortactin complex and stretch-activated cation channel on actin cytoskeleton
- 2009 - 2011 医工学的解析に基づく肺ストレッチセンサーを介した肺癌発症機構の解明
- 2009 - 2011 Elucidation of the mechanisms of nociceptor excitation by noxious temperature
- 2009 - 2011 Mechanical response in artificially controlled osteocyte network
- 2008 - 2010 生体メカノセンサーの制御操作による新規心不全治療の開発
- 2007 - 2010 心不全におけるCa2+ハンドリング機構解明と是正治療の開発
- 2008 - 2010 Coronary Circulation-Cardiac Mechanics Coupling
- 2008 - 2010 Role of mechanical load in human myocardial excitation contraction coupling
- 2007 - 2009 The role of mechanosensor on cardiovascular disease.
- 2005 - 2009 Application of Soft Lithography to Mechanobiology
- 2007 - 2008 未熟児網膜症におけるヘモグロビン変換の関与
- - 2006 心不全発症におけるNa+/Ca2+交換体の役割
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Papers (41)：
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Yuki Katanosaka. Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy. J Gen Physiol. 2022. 154. 9. e2021esc45
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Kazufumi Nakamura, Satoshi Akagi, Yuki Katanosaka. pathophysiological involvements of stretch-activated channels in pulmonary hypertension. 2022. 5. 473. 63-65
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Hideki Nakamoto, Yuki Katanosaka, Ryota Chijimatsu, Daisuke Mori, Fengjun Xuan, Fumiko Yano, Yasunori Omata, Yuji Maenohara, Yasutaka Murahashi, Kohei Kawaguchi, et al. Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage. Arthritis & rheumatology (Hoboken, N.J.). 2021. 73. 8. 1441-1450
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Yoshihiro Ujihara, Motoi Kanagawa, Satoshi Mohri, Satomi Takatsu, Kazuhiro Kobayashi, Tatsushi Toda, Keiji Naruse, Yuki Katanosaka. Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure. Nature communications. 2019. 10. 1. 5754-5754
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Katanosaka K, Takatsu S, Mizumura K, Naruse K, Katanosaka Y. TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons. Scientific reports. 2018. 8. 1. 16782
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MISC (17)：
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Katrien De Clercq, Vicente Perez-Garcia, Jorge Lopez-Tello, Yuki Katanosaka, Thomas Voets, Amanda N. Sferruzzi-Perri, Joris Vriens. TRPV2 IS INVOLVED IN SYNCYTIALIZATION OF HUMAN AND MOUSE TROPHOBLAST. PLACENTA. 2021. 112. E80-E80
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Katrien De Clercq, Jorge Lopez-Tello, Yuki Katanosaka, Thomas Voets, Amanda N. Sferruzzi-Perri, Joris Vriens. STRAIN-SPECIFIC ADAPTATIONS IN PLACENTAL TRANSPORT FUNCTION OPTIMISE FETAL OUTCOMES IN MICE LACKING TRPV2. PLACENTA. 2021. 112. E20-E20
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Yuki Katanosaka. Abnormal structure of Golgi-microtubule network in muscular dystrophy-associated heart failure. 2021. 278. 3. 231-232
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Katrien De Clercq, Jorge Lopez-Tello, Yuki Katanosaka, Thomas Voets, Amanda N. Sferruzzi-Perri, Joris Vriens. Mice Lacking TRPV2 Adopt Compensatory Mechanism to Comply with Fetal Needs. REPRODUCTIVE SCIENCES. 2020. 27. SUPPL 1. 250A-250A
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Yuki Katanosaka, Makoto Shibuya, Yoshihiro Ujihara, Satoshi Mohri, Keiji Naruse. TRPV2 is Crucial for the Development of Intercalated Discs in Mouse Hearts. BIOPHYSICAL JOURNAL. 2019. 116. 3. 538A-538A
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Lectures and oral presentations (35)：
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The role of TRPV2 in pressure overload-induced pathological cardiac remodeling
(9th world congress of biomechanics 2022)
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TRPV2 is essential for the maturation and hypertrophic responses of cardiomyocytes via promotion of sarcoplasmic reticulum Ca2+ ATPase (SERCA) expression
(9th world congress of biomechanics 2022)
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細径線維受容器終末のTRPV2チャネルを介した機械痛覚の末梢神経機構
(日本基礎理学療法学会 2021)
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Analysis of Molecular Mechanisms Involved in Mechanical Adaptation: In the Case of Repeated Bout Effect on the Exercise-induced Muscle Pain.
(The 3rd International Yangtze River Delta Symposium on Mechanobiology & the 9th Chinese National Symposium of Medical Biophysics 2021)
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TRPV2 is Involved in the Hypertrophic Response of Skeletal Muscle Induced by Mechanical Overload
(The 3rd International Yangtze River Delta Symposium on Mechanobiology & the 9th Chinese National Symposium of Medical Biophysics 2021)
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Education (1)：
Professional career (1)：
Work history (7)：
Association Membership(s) (4)：
米国細胞生物学会
, 米国生物物理学会
, THE PHYSIOLOGICAL SOCIETY OF JAPAN
, 日本薬理学会
