Rchr
J-GLOBAL ID:201801014431342153   Update date: Feb. 20, 2024

Uehara Takashi

Uehara Takashi
Affiliation and department:
Job title: 教授
Research field  (1): Pharmacology
Research theme for competitive and other funds  (35):
  • 2022 - 2024 Epigenetic changes in gene expression by nitric oxide
  • 2018 - 2023 Environmental electrophiles exposome and reactive sulfur species as its regulator molecule
  • 2022 - 2023 Isolation of compound that specifically prevents oxidation-dependent ER stress sensor inhibition
  • 2017 - 2022 Life science basis of short-lived reactive species originated from foods
  • 2019 - 2021 Development of specific oxidative modification inhibitor for endoplasmic reticulum stress sensor
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Papers (62):
  • Yuta Iijima, Ryohei Miki, Nobumasa Takasugi, Masatake Fujimura, Takashi Uehara. Characterization of pathological changes in the olfactory system of mice exposed to methylmercury. Archives of Toxicology. 2024
  • Atsushi Morimoto, Nobumasa Takasugi, Yuexuan Pan, Sho Kubota, Naoshi Dohmae, Yumi Abiko, Koji Uchida, Yoshito Kumagai, Takashi Uehara. Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling. Journal of Biological Chemistry. 2024
  • Yuta Iijima, Ryohei Miki, Masatake Fujimura, Seiichi Oyadomari, Takashi Uehara. Methylmercury-induced brain neuronal death in CHOP-knockout mice. The Journal of Toxicological Sciences. 2024. 49. 2. 55-60
  • Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi. Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. Journal of Lipid Research. 2024. 100510-100510
  • Rikako Taniguchi, Yuto Moriya, Naoshi Dohmae, Takehiro Suzuki, Kengo Nakahara, Sho Kubota, Nobumasa Takasugi, Takashi Uehara. Attenuation of protein arginine dimethylation via S-nitrosylation of protein arginine methyltransferase 1. Journal of Pharmacological Sciences. 2023
more...
MISC (19):
  • Tomoki Tsuchida, Takashi Uehara. Molecular mechanism of EGFR signaling evoked by environmental pollutant 1,2-naphthoquinone. Folia Pharmacologica Japonica. 2022. 157. 5. 352-355
  • 安孫子ユミ, 新開泰弘, 鵜木隆光, 広瀬玲子, 上原孝, 熊谷嘉人. 1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化はポリサルファイドモデル化合物Na2S4により抑制される. 日本酸化ストレス学会学術集会プログラム・抄録集. 2017. 70th
  • 鵜木隆光, 安孫子ユミ, 新開泰弘, 広瀬玲子, 上原孝, 熊谷嘉人. ポリスルフィドNa2S4はイオウ付加体形成を通じて1,4-NQによるPTEN/Akt/CREBシグナルの活性化と細胞毒性を抑制する. 衛生薬学・環境トキシコロジー講演要旨集. 2017. 2017
  • 安孫子ユミ, 新開泰弘, 鵜木隆光, 広瀬玲子, 上原孝, 熊谷嘉人. ポリサルファイドモデル化合物Na2S4は1,4-NQ曝露によるPTEN/Akt/CREBシグナルの活性化を抑制する. Journal of Toxicological Sciences. 2017. 42. Supplement
  • 鵜木隆光, 安孫子ユミ, 外山喬士, 外山喬士, 上原孝, 坪井康次, 西田基宏, 西田基宏, 鍜治利幸, 熊谷嘉人. 親電子物質による生体影響の二面性:SH-SY5Y細胞におけるメチル水銀曝露により生じるAkt/CREB/Bcl-2経路の活性化と破綻. 衛生薬学・環境トキシコロジー講演要旨集. 2016. 2016
more...
Professional career (1):
  • PhD (Hokkaido Univ)
Awards (4):
  • 2016/07 - 日本学術振興会 特別研究員等審査会専門委員表彰
  • 2011/09 - 日本学術振興会 科研費助成事業第一段審査委員表彰
  • 2005/09 - 日本神経化学会 奨励賞
  • 2003/03 - 日本薬学会 奨励賞
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