- 2024 - 2029 健康・老化・老人性疾患における酸化ストレス依存的エピゲノム変化の意義
- 2024 - 2028 Integrated understanding of the mechanisms of maintenance and breakdown of epigenomic resilience for health
- 2024 - 2025 DNAメチル化酵素のS-ニトロシル化修飾を特異的に抑制する低分子化合物を用いた新型コロナウイルス感染後遺症治療法の開発
- 2023 - 2024 新型コロナウイルス感染に伴う過剰NO産生を介したエピゲノム変化・後遺症発現に対する 独自開発化合物の効果
- 2022 - 2024 Epigenetic changes in gene expression by nitric oxide
- 2018 - 2023 Environmental electrophiles exposome and reactive sulfur species as its regulator molecule
- 2022 - 2023 Isolation of compound that specifically prevents oxidation-dependent ER stress sensor inhibition
- 2017 - 2022 Life science basis of short-lived reactive species originated from foods
- 2019 - 2021 Development of specific oxidative modification inhibitor for endoplasmic reticulum stress sensor
- 2018 - 2021 Mechanism of epigenetic regulation by nitric oxide with a novel compound regulating the modification of cysteine residue
- 2018 - 2021 Biological effect and preventive method for human serum albumin binding to transboundary air borne PM2.5.
- 2017 - 2019 Novel regulatory mechanism of Abeta degradation via ER stress
- 2014 - 2019 Polysulfur metabolome and regulation of anti-oxidative stress responses
- 2015 - 2018 Regulation of epigenetic enzymes via nitrosative stress and development of its specific modulator
- 2015 - 2017 Regulation of unfolded protein response by oxidative stress
- 2013 - 2015 Identification of novel target proteins of NO with new screening system
- 2008 - 2014 Signaling Functions of Reactive Oxygen Species
- 2011 - 2012 Detection of oxidized ERprotein by nitrosative/oxidative stress with a specific antibody
- 2010 - 2012 Molecular mechanism of neuronal cell death induced by methyl mercury via endoplasmic reticulum stress
- 2008 - 2012 Molecular mechanism of nitric oxide/nitrosative stress implicating in onset of neurodegenerative disorders
- 2009 - 2010 新規小胞体膜ユビキチンリガーゼの基質探索と神経生理機能特定
- 2007 - 2008 神経変性疾患発症における一酸化窒素による小胞体膜存在ユビキチンリガーゼの機能変化
- 2007 - 2008 The inhibitory mechanism of novel proteins induced in the endoplasmic reticulum and of drugs on neurodegenerative diseases
- 2007 - 2008 The role of nitrosylation of neurotransmitter transporterin pain-induced aversion
- 2006 - 2008 Pathophysiological function of nitric oxide on protein quality control system in endoplasmic reticulum.
- 2005 - 2006 Possible relationship between S-nitrosylated proteins and neurodegenerative disorders
- 2003 - 2006 Studies on the Regulatory Mechanism of Neuronal Death: Isolation of Novel Factors and Title of Preparation of Model of Neurodegenerative Disease.
- 2004 - 2005 小胞体に蓄積する変性蛋白質の修復/分解系を用いた神経変性疾患防御機構
- 2002 - 2003 小胞体での変性蛋白質分解に関与する分子の単離・同定と神経変性疾患防御機構
- 2001 - 2003 脳ニューロン・グリア細胞相関系のストレス応答機構に関する細胞分子生物学的研究
- 2001 - 2002 脳虚血によるニューロン死惹起機構に関わる新規因子の探索・同定
- 2000 - 2002 Preparation of animal model with higher brain dysfunction : studies on evaluation methods of active chemicals
- 1999 - 2000 ニューロン・グリアにおける脳虚血ストレス応答の細胞内機構
- 1998 - 2000 Mechanisms of cellular and intracellular functions in brain-immune qnetwork.
- 1997 - 1999 Development of model animals and cells for neuronal disease
- 1997 - 1998 脂肪細胞分化を誘導するインスリンの細胞内情報伝達系の解析
- 1996 - 1996 マウス3T3-L1細胞の分化におけるインスリンの情報伝達系の解析
- 1995 - 1996 Establishment and estimation of pharmacological bioassay system for therapeutic drugs of aging in central nervous system.
- 1995 - 1995 マウス3T3-L1細胞の分化におけるインスリンの情報伝達系の解析
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