Ishimaru Kazuhiro

Affiliation and department：

Research field (1)： Internal medicine - General

Research theme for competitive and other funds (2)：

2019 - 2022 Elucidation of aging lung pathophysiology through sphingolipid signaling
2016 - 2019 生体膜スフィンゴ脂質レベルを制御する鍵酵素による動脈硬化抑制の分子機構

Papers (12)：

Jun-ichi Morishige, Kazuaki Yoshioka, Hiroki Nakata, Kazuhiro Ishimaru, Naoto Nagata, Tamotsu Tanaka, Yoh Takuwa, Hitoshi Ando. Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes. Journal of Lipid Research. 2023. 100450-100450
Shahidul Islam, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Hiroki Yamada, Noriko Takuwa, Yoh Takuwa. Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice. The journal of physiological sciences : JPS. 2020. 70. 1. 18-18
Ishimaru K, Yoshioka K, Kano K, Kurano M, Saigusa D, Aoki J, Yatomi Y, Takuwa N, Okamoto Y, Proia RL, et al. Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation. Scientific reports. 2019. 9. 1. 18329-18329
Aung KT, Yoshioka K, Aki S, Ishimaru K, Takuwa N, Takuwa Y. The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells. The journal of physiological sciences : JPS. 2019. 69. 2. 263-280
Sarker MAK, Aki S, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, Takuwa Y. Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice. Endocrinology. 2019. 160. 1. 235-248

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MISC (6)：

Keita Kimura, Akinari Hinoki, Kazuhiro Ishimaru, Sadaharu Higuchi, Kunie Eguchi, Gerald D. Frank, Satoru Eguchi. Endothelial Nitric Oxide Synthase Inhibits G12/13 and Rho-Kinase Activated by the Angiotensin II Type-1 Receptor: Implication in Vascular Migration. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009. 29. 7. E91-E91
Keita Kimura, Akinari Hinoki, Kazuhiro Ishimaru, Sadaharu Higuchi, Kunie Eguchi, Michael V. Autieri, Laura J. Sommerville, Gerald D. Frank, Satoru Eguchi. Role of PAK1 Activation in Migration of VSMC in Vitro and in Arterial Neointima Formation in Vivo. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009. 29. 7. E57-E57
Akinari Hinoki, Keita Kimura, Kunie Eguchi, Sadaharu Higuchi, Kazuhiro Ishimaru, Michael V. Autieri, Laura J. Sommerville, Gerald D. Frank, Satoru Eguchi. Signal Cross-Talk Between PDGF Receptor beta and G12/13 Mediates Vascular Smooth Muscle Cell Migration by PDGF-BB: Implication in Neointima Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009. 29. 7. E56-E57
Daisuke Takabayashi, Hitoshi Ueno, Satoshi Kagitani, Kazuhiro Ishimaru, Hidenori Sugawara, Masanobu Takata, Hiroshi Inoue. Suppression of NF-kappab activity attenuates renal inflammatory response and fibrosis independently of blood pressure in DOCA/salt hypertensive rats. JOURNAL OF HYPERTENSION. 2006. 24. 291-291
Kazuhiro Ishimaru, Hitoshi Ueno, Satoshi Kagitani, Daisuke Takabayashi, Hiroshi Inoue, Masanobu Takata. Aldosterone was associated with myocardial fibrosis both in essential hypertension patient and primary aldosteronism. JOURNAL OF HYPERTENSION. 2006. 24. 227-227

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Lectures and oral presentations (6)：

Sphingosine Kinase 2 Inhibits Macrophage Cholesterol Accumulation and Atherosclerosis via Autophagy Stimulation
(American Heart Association 2018 Scientific Sessions 2018)
S1P2によるブレオマイシン誘発肺線維症の増悪機構の検討:肺胞マクロファージの細胞老化制御の関与
(第28回日本病態生理学会大会 2018)
Novel indispensable role of and isoforms of class II PI3K for uterine smooth muscle contraction and labor
(2018)
Class II phosphoinositide 3-kinase isoforms PI3K-C2αand PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells
(2018)
Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells
(2018)

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