Kobayashi Isao

Affiliation and department：
Job title： Associate Professor

Research field (2)： Zoological sciences , Developmental biology

Research keywords (5)： Hematopoietic stem cell , Zebrafish , Stem cell niche , Angioblast , Osteoclast

Research theme for competitive and other funds (21)：

2023 - 2027 Role of transcription factor Tfcp2l1 in growth spurt phenomena in zebrafish
2023 - 2026 Study on prevention of bone disease using fish induced hyperglycemia: Effect of food containing melatonin.
2021 - 2024 Identification of niche cells for supporting colonization, proliferation, and differentiation of xenogenic donor germ cells in recipient gonads.
2020 - 2023 Regulatory mechanism of osteoclasts by hormones produced in osteoblasts: analysis using fish scales as a bone model
2022 - 2023 双性イオン液体によるライフサイエンス基盤の革新と社会実装

Show all

Papers (34)：

Jingjing Kobayashi-Sun, Isao Kobayashi, Makoto Kashima, Jun Hirayama, Makiko Kakikawa, Sotoshi Yamada, Nobuo Suzuki. Extremely low-frequency electromagnetic fields facilitate both osteoblast and osteoclast activity through Wnt/β-catenin signaling in the zebrafish scale. Frontiers in Cell and Developmental Biology. 2024. 12
Masaharu Hazawa, Dini Kurnia Ikliptikawati, Yuki Iwashima, De-Chen Lin, Yuan Jiang, Yujia Qiu, Kei Makiyama, Koki Matsumoto, Akiko Kobayashi, Goro Nishide, et al. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells. Cell Chemical Biology. 2023. in press
Junya Tamaoki, Hiroki Maeda, Isao Kobayashi, Miki Takeuchi, Ken Ohashi, Aniket Gore, Florian Bonkhofer, Roger Patient, Brant M. Weinstein, Makoto Kobayashi. LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Developmental Biology. 2023. 501. 92-103
Yukari Miki, Azusa Seki, Hiroyuki Mishima, Yusuke Maruyama, Kazuki Watanabe, Jingjing Kobayashi-Sun, Isao Kobayashi, Kohei Kuroda, Shion Oshima, Takeru Okamoto, et al. Melatonin is more effective on bone metabolism when given at early night than during the day in ovariectomized rats. Melatonin Research. 2023. 6. 161-172
Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, et al. The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants. Journal of Molecular and Cellular Cardiology. 2023. 177. 50-61

ｍore...

MISC (13)：

小林功. 造血系の進化2:腎臓の成り立ちと魚類の造血. 腎臓内科. 2022. 16. 2. 209-214
Yukino Wada, Isao Kobayashi. Jagged-2b triggers intercellular signaling in the somite to establish the hematopoietic stem cell fate in zebrafish. Experimental Hematology-Supplement. 2021. 100. S52
Mao Kondo, Shiori Yamamori, Jingjing Kobayashi-Sun, Makoto Taniguchi, Kaori Kanemaru, David Traver, Isao Kobayashi. The Sinusoidal Endothelium Functions as a Hematopoietic Niche in the Zebrafish Kidney. Experimental Hematology-Supplement. 2019. 76. S72
Isao Kobayashi, Jingjing Kobayashi-Sun. Jam3b regulates hemato-vascular development through the repression of the Erk signaling pathway. Experimental Hematology-Supplement. 2018. 64. S77
小林功. Regulation of Hematopoietic Stem Cell Development by Notch Signaling. 細胞工学. 2016. 35. 1. 60-64

ｍore...

Books (1)：

Zebrafish, Medaka, and other small fishes : new model animals in biology, medicine, and beyond
Springer Nature Singapore 2018 ISBN:9789811318788

Lectures and oral presentations (42)：

Developing hematopoietic stem cells acquire adaptability to the final hematopoietic niche
(2022)
母性由来Abcg2aは背側化を抑制して造血・血管発生を促進する
(2021)
Jagged-2bは体節内細胞間シグナル伝達を介して造血幹細胞の発生を制御する
(2021)
ゼブラフィッシュにおいて古典的Wntシグナルの阻害は造血幹細胞を維持する
(2021)
Inhibition of canonical Wnt signaling maintains hematopoietic stem cells in zebrafish
(2021)

ｍore...

Education (2)：

2006 - 2009 Nihon University Graduate School of Veterinary Medicine
2000 - 2006 Nihon University College of Bioresource Sciences Department of Veterinary Medicine

Professional career (1)：

博士(獣医学) (日本大学)

Work history (8)：

2020/11 - 現在 Kanazawa University
2018/04 - 2020/10 Kanazawa University
2015/11 - 2018/03 Kanazawa University
2015/04 - 2015/10 University of California, San Diego Department of Molecular Medicine
2013/04 - 2015/03 University of California, San Diego Department of Molecular Medicine

Show all

Committee career (2)：

2022 - 第55回日本発生生物学会運営委員
2021 - 第27回小型魚類研究会運営委員

Awards (1)：

2013/08 - International Society of Experimental Hematology (ISEH) Christa Muller-Sieburg Award

Association Membership(s) (4)：

日本発生生物学会 , 日本分子生物学会 , 小型魚類研究会 , International Society for Experimental Hematology (ISEH)

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page