Onodera Atsushi

Affiliation and department：
Job title： Prpfessor

Research field (2)： Molecular biology , Immunology

Research keywords (5)：ポリコーム・トライソラックス群 , TET enzyme , DNAメチル化 , ヒストン修飾 , T細胞

Research theme for competitive and other funds (8)：

2022 - 2025 -
2021 - 2022 -
2018 - 2021 Active and passive DNA demethylation in T cells
2014 - 2019 Elucidation of pathogenic immune memory formation and maintenance
2015 - 2018 Epigenetic regulation of the memory T cell response

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Papers (47)：

Ami Aoki, Chiaki Iwamura, Masahiro Kiuchi, Kaori Tsuji, Atsushi Sasaki, Takahisa Hishiya, Rui Hirasawa, Kota Kokubo, Sachiko Kuriyama, Atsushi Onodera, et al. Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients. Journal of Clinical Immunology. 2024. 44. 4
Mariko Takami, Takahiro Aoki, Katsuhiro Nishimura, Hidekazu Tanaka, Atsushi Onodera, Shinichiro Motohashi. Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner. Cancer research communications. 2024. 4. 2. 446-459
Atsushi Onodera, Kota Kokubo, Mikiko Okano, Miki Onoue, Masahiro Kiuchi, Chiaki Iwamura, Tomohisa Iinuma, Motoko Y. Kimura, Nobuyuki Ebihara, Toyoyuki Hanazawa, et al. Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacology & Therapeutics. 2023. 247. 108445-108445
Ryo Koyama-Nasu, Motoko Y Kimura, Masahiro Kiuchi, Ami Aoki, Yangsong Wang, Yukiyoshi Mita, Ichita Hasegawa, Yukihiro Endo, Atsushi Onodera, Kiyoshi Hirahara, et al. CD69 imposes tumor-specific CD8+ T-cell fate in tumor-draining lymph nodes. Cancer immunology research. 2023
Hiroshi Yuita, Isaac F López-Moyado, Hyeongmin Jeong, Arthur Xiuyuan Cheng, James Scott-Browne, Jungeun An, Toshinori Nakayama, Atsushi Onodera, Myunggon Ko, Anjana Rao. Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 6. e2214824120

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MISC (16)：

小野寺淳, 本橋新一郎. シングルセル解析. 耳鼻咽喉科. 2022. 2. 5. 666-671
小野寺淳, 木内政宏, 中山俊憲. Epigenetic regulation of T cell-mediated inflammation by CxxC family proteins. 月刊アレルギーの臨床. 2021. 560
小久保幸太, 小野寺淳, 中山俊憲. 【アレルギーの分子細胞機構】エフェクター、メモリーTh2細胞の誘導と維持のエピジェネティクス. 臨床免疫・アレルギー科. 2019. 72. 2. 117-121
平原潔, 森本侑樹, 木内政宏, 和田朋子, 市川智巳, 岡野美樹子, 小野寺淳, 櫻井大樹, 岡本美孝, 中山俊憲. アレルギー疾患線維化誘導病原性ヘルパーT細胞が誘導する組織線維化の形成機構について. 日本臨床免疫学会総会プログラム・抄録集. 2018. 46回. 76-76
平原潔, 森本侑樹, 木内政宏, 和田朋子, 市川智巳, 岡野美樹子, 小野寺淳, 櫻井大樹, 岡本美孝, 中山俊憲. 好酸球性気道炎症の病態:自然免疫と獲得免疫好酸球性気道炎症において線維化誘導-病原性ヘルパー細胞が誘導する組織線維化の形成機構について. アレルギー. 2018. 67. 4-5. 414-414

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Books (8)：

上田宏の思い出
株式会社シービーアール 2023 ISBN:9784911108222
基礎から学ぶ免疫学
羊土社 2023 ISBN:9784758121682
エッセンシャル免疫第4版
メディカル・サイエンス・インターナショナル 2023 ISBN:9784815730819
JANEWAY’S 免疫生物学原書第9版
南江堂 2019 ISBN:9784524251155
The Interplay between Transcription Factors and Epigenetic Modifications in Th2 Cells.
2018 ISBN:9789535138563

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Lectures and oral presentations (63)：

DNA demethylation in the immune system: do TET and TDG play roles?
(Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop 2024)
Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic type 2 adaptive immunity via the PPARg-ST2 axis
(Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop 2024)
In Memory of Toshi: Toshi's Research Achievement in Epigenetics & Gene Expression
(Dr. Toshinori Nakayama Memorial cMAV-cSIMVa Workshop 2024)
Overview Talk: Epigenetic regulation in health and disease
(2024)
Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism
(2024)

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Education (3)：

2006 - 2010 千葉大学大学院医学薬学府
2002 - 2006 千葉大学医学部
1998 - 2002 The University of Tokyo

Professional career (1)：

博士(医学) (千葉大学)

Work history (6)：

2023/07 - 現在 Chiba University Prpfessor
2022/04 - 2023/06 千葉大学大学院医学研究院(国際高等研究基幹・国際アレルギー粘膜免疫学) 准教授
2021/07 - 2022/03 Chiba University
2016/08 - 2021/06 千葉大学グローバルプロミネント研究基幹准教授
2012 - 2016/07 千葉大学大学院医学研究院助教

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Awards (7)：

2023/10 - 千葉大学千葉大学先進学術賞メチル基によるエピゲノム修飾と疾患制御機構の解明
2018/02 - School of Medicine, Chiba University Educator Award of Scholarship Program, School of Medicine, Chiba University
2017/02 - The Inaugural Chiba University - UC San Diego Symposium on Mucosal Immunology Best Poster Presentation賞
2016 - International Congress of Immunology Novo Nordisk International Travel Bursary for the 16th International Congress of Immunology
2012 - 千葉医学会千葉医学会奨励賞免疫系におけるエピジェネティック機構の解明と応用

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