Kubo Takanori

クボタカノリ | Kubo Takanori

Affiliation and department：

Research field (1)： Biochemistry

Research keywords (9)：生物有機化学 , ケミカルバイオロジー , バイオテクノロジー , アンチセンス , RNAi , oligonucleotide therapeutics , nucleic acid , bioconjugate , siRNA

Research theme for competitive and other funds (23)：

2022 - 2025 メモリー様分化誘導を基盤とした多種類のがんに有効なCAR-NK細胞製剤の新規開発
2022 - 2025 多発性骨髄腫のマクロファージ活性化と協調効果を示すiPSキラーCAR-Tの開発
2019 - 2022 Development of the immune checkpoint inhibitor using the Lipid-siRNA conjugates encapsulated with exosome
2019 - 2022 Mechanism of intestinal barrier disruption caused by free heme causing aggravation of sepsis
2016 - 2019 Antitumor Effect of Lipid-Conjugated siRNA using multi-gene silencing method

2016 - 2019 Development of novel dihydropyrimidine retinoids for medicinal chemistry and drug dicovery

2016 - 2019 マルチ遺伝子サイレンシング法を利用したがん転移を抑制する脂質修飾siRNAの開発

2016 - 2019 医薬応用に向けたジヒドロピリミジン誘導体のレチノイドとしての機能開発

2017 - 2018 siRNAによるマウスにおける癌治療モデルの確立

2014 - 2016 Synergy of gene silencing of lipid conjugate siRNAs targeting multiple oncogenes

2015 - 2016 慢性骨髄性白血病細胞のBcr-Abl融合遺伝子を標的とした修飾型siRNAのRNAi効果について

2014 - 2016 複数のがん関連遺伝子を標的とした脂質コンジュゲートsiRNAの相乗効果

2014 - 2015 慢性骨髄性白血病細胞のBcr-Abl融合遺伝子を標的とした修飾型siRNAのRNAi効果について

2014 - 2015 In vivoにおける脂肪酸修飾型2本鎖RNAのRNA干渉効果についての研究

2013 - 2014 パルミチン酸結合型2本鎖RNAのin vivoでの遺伝子発現抑制効果に関する研究

2013 - 2014 In vivoにおける脂肪酸修飾型2本鎖RNAのRNA干渉効果についての研究

2013 - 2013 Potent Gene Silencing in a Liver-Metastatic Tumor Mouse Model Using Lipid Conjugated siRNAs.

2012 - 2013 パルミチン酸結合型2本鎖RNAのin vivoでの遺伝子発現抑制効果に関する研究

2012 - 2013 In vivoにおける脂肪酸修飾型2本鎖RNAのRNA干渉効果についての研究

2009 - 2011 新規な機能性分子融合型2本鎖RNAの開発

2009 - 2010 Development of siRNAs conjugated with bioactive molecule

2003 - 2004 DNAコンジュゲートによる多機能集積型遺伝子医薬の開発

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Papers (91)：

Takanori Kubo, Kazuyoshi Yanagihara, Yoshio Nishimura, Yuki Iino, Teruo Komatsu, Rina Tansou, Keichiro Mihara, Toshio Seyama. Antitumor Effect of Oleoyl-siRNA against Pancreatic Cancer Using a Portal Vein Infusion Liver-Metastatic Mouse Model. Molecular Pharmaceutics. 2024. 21. 10. 5115-5125
Yuji Hattori, Takanori Kubo, Seiji Nagano, Takahiko Miyama, Yoshitaka Taniguchi, Yoshitaka Iba, Nobuko Ohshima, Rie Kanehara, Takakazu Kawase, Masahide Takahashi, et al. Anti-CD38-CAR IPS-Derived Cytotoxic T Lymphocytes Efficiently Eliminate Myeloma Cells Treated with Daratumumab and Isatuximab in Vitro and In Vivo. Blood. 2023. 142. Supplement 1. 3312-3312
Kohei Kawabata, Yuichiro Sato, Takanori Kubo, Akira Tokumura, Hiroyuki Nishi, Kinjiro Morimoto. Phospholipid analysis of two influenza A virus-infected cell lines differing in their viral replication kinetics. Archives of virology. 2023. 168. 5. 132-132
Yoshio Nishimura, Takanori Kubo, Nanami Shibuya, Hidetsura Cho. Fully Substituted Dihydropyrimidines, Pentasubstituted 2-Aryldihydropyrimidines Synthesized by Palladium-Catalyzed/Copper-Mediated Cross-Coupling Reaction. Synthesis. 2023
Sachiye Inouye, Takanori Kubo, Takafumi Miyamoto, Takuya Iyoda, Naoyuki Okita, Reiko Akagi. Heat shock-induced heme oxygenase-1 expression in a mouse hepatoma cell line is dependent on HSF1 and modified by NRF2 and BACH1. Genes to cells : devoted to molecular & cellular mechanisms. 2022. 27. 12. 719-730

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MISC (161)：

久保貴紀, 湛増里奈, 西村良夫, 黒澤静霞, 牧野誠, 大野美季, 谷口佳隆, 柳原五吉, 瀬山敏雄. RNAi potency of chemically modified lipid-siRNA conjugates. 日本薬学会年会要旨集(Web). 2024. 144th
西村良夫, 平圭登, 山本悠介, 久保貴紀, 長秀連. Synthesis and analysis of stability of 6-unsubstituted 2-aryl-1,4-dihydropyrimidine tautomers by Pd-catalyzed/CuCl-mediated Liebeskind-Srogl-type cross-coupling reaction. 日本薬学会年会要旨集(Web). 2024. 144th
湛増里奈, 久保貴紀, 森本金次郎, 羽鳥勇太, 瀬山敏雄. Inhibition of Influenza A virus replication by Lipid-siRNA conjugates. 日本薬学会年会要旨集(Web). 2024. 144th
松田和大, 上田耕平, 黒澤静霞, 大野美季, 鬼塚拓男, 久保貴紀, 瀬山敏雄, 谷口佳隆. NanoSIMSを用いたsiRNAの細胞内分布の高分解能イメージング. 日本DDS学会学術集会プログラム予稿集. 2023. 39回. 193-193
湛増里奈, 久保貴紀, 西村良夫, 大野美季, 谷口佳隆, 柳原五吉, 柳原五吉, 三原圭一朗, 瀬山敏雄. RNAi efficacy of lipid-conjugated siRNAs against immune checkpoint. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2023. 8th

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Patents (23)：

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Professional career (1)：

Work history (6)：

2022/04 - 現在 Yasuda Women's University Faculty of Pharmacy Associate Professor
2014/04 - 2022/03 Yasuda Women's University Faculty of Pharmacy lecturer
2011/04 - 2014/03 Yasuda Womens's University Faculty of Pharmacy Assistant Professor
2008/05 - 2011/03 Yasuda Women's University Faculty of Pharmacy Research Associate
2005/04 - 2008/03 National Institute of Advanced Industrial Science and Technology AIST Kyushu Research Fellowship

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Awards (9)：

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