Toshiyuki Habu

Affiliation and department：

Research field (5)： Molecular biology , Physiology , Cell biology , Home economics, lifestyle science , Genetics

Research keywords (6)： Gulo gene safe harbor locus , Ubiquitin-signaling , moyamoya disewase (MMD) , stress response , RNF213 , 血管形成

Research theme for competitive and other funds (9)：

2022 - 2025 Role of RNF213 as a novel endoplasmic reticulum stress regulator in diabetes mellitus.
2017 - 2022 Mechanism and processe of stenoocclusive vascular diseases caused by RNF213 mutation in inflammatory cellular society
2015 - 2018 Analysis of reletionship between RNF213 moyamoya factor and autophagy
2013 - 2016 Molecular pathology of moyamoyta disease and its translational research toward prevention and drug development
2011 - 2013 Analysis of p53 72SNP in stress responce

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Papers (41)：

小林果, Ahmed Sharif, 土生敏行, 及川伸二, 小泉昭夫, 村田真理子. もやもや病感受性遺伝子RNF213が小胞体ストレスに与える影響. 日本衛生学雑誌. 2023. 78. Suppl. S210-S210
Toshiyuki Habu, Jiyeong Kim. Protocol for combining immunological procedures with cell cycle stage synchronization to detect cell-cycle-specific complexes. STAR Protocols. 2023. 4. 1. 102063-102063
Toshiyuki Habu, Jiyeong Kim. Ubiquitination Enzymes. Hydrolases. 2022
Sharif Ahmed, Toshiyuki Habu, Jiyeong Kim, Hiroko Okuda, Shinji Oikawa, Mariko Murata, Akio Koizumi, Hatasu Kobayashi. Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation. Biochemical and Biophysical Research Communications. 2022. 609. 62-68
Toshiyuki Habu, Honoka Ishikawa, Jiyeong Kim. Gulo gene locus, a new Gene Editing locus for mammalian cells. Biotechnology Journal. 2022. 2100493-2100493

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MISC (26)：

AHMED SHARIF, 小林果, 奥田裕子, 原田浩二, 土生敏行, YOUSSEFIAN SHOHAB, 及川伸二, 村田真理子, 小泉昭夫. Rnf213 suppression did not improve diabetes phenotype in female Akita mouse in contrast to male Akita mouse. 日本衛生学雑誌. 2021. 76巻. suppl. 160-160
奥田裕子, 竹谷朱, 小林果, 土生敏行, 原田浩二, ユーセフィアンショハブ, 小泉昭夫. 小児四肢疼痛発作症の神経過興奮メカニズム解明のためのNav1.8欠損マウスの作出. 日本衛生学雑誌. 2021. 76巻. suppl. 198-198
武田美都里, キム・ミンソ, 小林果, 原田浩二, 土生敏行, 小泉昭夫, ユーセフィアン・ショハブ. もやもや病タンパク質RNF213のE3 ligase活性の機能的評価. 日本衛生学雑誌. 2018. 73. Suppl. S265-S265
Robert S. Banh, Caterina Iorio, Richard Marcotte, Yang Xu, Dan Cojocari, Anas Abdel Rahman, Judy Pawling, Ankit Sinha, Toshiaki Hitomi, Toshiyuki Habu, et al. PTP1B regulates the Moyamoya disease-associated E3 ligase, RNF213 and cellular dioxygenase activity to allow breast tumor survival in hypoxia. CANCER RESEARCH. 2015. 75
人見敏明, 小林果, 奥田裕子, 曽根正勝, 田浦大輔, 原田浩二, 土生敏行, 小泉昭夫. MysterinはIFNβによる抗血管形成シクナル経路のメディエターとして働く. 日本衛生学雑誌. 2015. 70. Suppl. S197-S197

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Books (2)：

The Role of Lysine 63 Linked Ubiquitination in Health and Disease
2022 ISBN:9798886972818
Moyamoya Disease: Current Knowledge and Future Perspectives
2021

Education (1)：

Professional career (1)：

Work history (3)：

2023/04 - 現在 Mukogawa Women's University School of Food Sciences and Nutrition Department of Food Sciences and Nutrition
2015/04 - 2023/03 Mukogawa Women's university Department of Food sciences and Nutrition
2002/04 - 2015/03 Kyoto University Radiation Biology center

Association Membership(s) (1)：

日本癌学会

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