Research field (3)：
Immunology
, Tumor biology
, Pathobiochemistry
Research keywords (8)：
Gravity response
, メカノホメオスターシス
, Organoid
, Immunology
, Cancer
, 3D organogenesis
, Regeneration
, Developmental Genetics
Research theme for competitive and other funds (30)：
2023 - 2026 膀胱癌における一次繊毛の中心体制御メカニズム解明による新たな治療戦略の創出
2023 - 2025 The body construction by you push me I push you back YAP mechanohomeostasis
2023 - 2025 Analysis of YAP-mechanohomeostasis mediated regeneration
2019 - 2024 AI System Medicine Platform toward precision medicine based on the mechanism forming a 3D organ
2022 - 2024 A mini-organ culture system with cancer immune microenvironment recapitulating in vivo
2021 - 2024 Elucidation of molecular feedback mechanisms underlying mechano-homeostasis governing 3D organ formation and regeneration
2021 - 2024 Pathological mechanism of ciliopathy in Patau syndrome using aneuploidy rescue technology
2021 - 2024 Analysis of mechanic regulation of YAP activation in cancer progression
2020 - 2023 低リスク網膜再生を実現する内在性幹細胞活性化-CRMP群のリン酸化制御-
2020 - 2023 Development of a bladder cancer drug-sensitivity platform based on cancer niche formation including immune cell components
2020 - 2023 Development of new immunotherapy for metastatic pancreatic cancer by applying organoids derived from circulating tumor cells in blood.
2020 - 2023 Development of opitimal drug screening using 3D in vitro prostate cancer organoid
2019 - 2022 3D intestinal development and carcinogenesis by Hippo-YAP pathway
2018 - 2021 The induction of retinal progenitor cells by the control of natural inflammation
2019 - 2021 Generation of a lymph node organoid enabling mechanical control of cancer immune response
2019 - 2021 YAP mechano-homeostasis mediated interplay of developmental clock and extracelluar environment in brain development
2017 - 2020 Investigation of bone microenvironment using 3D-organoid model.
2016 - 2020 Elucidation of the Hippo-Yes-YAP pathway in psoriasis vulgaris using a three-dimensional skin model
2017 - 2020 YAP による臓器全体の物理特性制御の分子機構の解明
2016 - 2019 Development of novel markers for drug screening and descovery of mechanism to neuroendocrine differentiation in castration resistant prostate cancer
2017 - 2019 A novel tissue culture system recapitulating in vivo physical properties
2004 - 2006 Establishment of Reverse Genetics in Medaka : Screening for Induced Point Mutations in Medaka with TILLING
1989 - 1990 Molecular Identification and Immunological Significance of I-J Molecule.
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Papers (127)：
Yanshu Zhang, Takao Kitagawa, Makoto Furutani-Seiki, Shige H Yoshimura. Yes-associated protein regulates cortical actin architecture and dynamics through intracellular translocation of Rho GTPase-activating protein 18. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 9. e23161
Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, et al. Correction: Medaka as a model for human nonalcoholic steatohepatitis. Disease models & mechanisms. 2023. 16. 7
Alberto D'Angelo, Kensuke Shibata, Masayuki Tokunaga, Makoto Furutani-Seiki, Stefan Bagby. Corrigendum to "Generation of murine tumour-reactive T cells by co-culturing murine pancreatic cancer organoids and peripheral blood lymphocytes". Biochemistry and biophysics reports. 2023. 33. 101374-101374
Alberto D'Angelo, Kensuke Shibata, Masayuki Tokunaga, Makoto Furutani-Seiki, Stefan Bagby. Generation of murine tumour-reactive T cells by co-culturing murine pancreatic cancer organoids and peripheral blood lymphocytes. Biochemistry and biophysics reports. 2022. 32. 101365-101365
Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, et al. Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. Nature communications. 2022. 13. 1. 6948-6948
