Hashiguchi Masaaki

ハシグチマサアキ | Hashiguchi Masaaki

Affiliation and department：

Research field (1)： Immunology

Research keywords (4)： IgA , IgE , innate lymphoid cells , mucosal immunity

Research theme for competitive and other funds (15)：

2022 - 2025 パイエル板Tfhによる抗体産生制御:対立遺伝子排除の破綻とアレルギーの抑制
2018 - 2021 Does IL-21 produced in Peyer's patch regulate the affinity of IgA and food allergy?
2015 - 2018 Peyer's patch immune cells regulates intestinal bacteria: basic research for the manipulation of intestinal bacteria by foods
2012 - 2015 Regulatory roles of HIF-1a and glycolysis in autoimmunity
2012 - 2015 Functional study of IL-5-producing cells in food allergy using GFP marking system

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Papers (42)：

Masaaki Hashiguchi, Tomoko Asatsuma-Okumura, Yoshiko Iwai. Interleukin 21 promotes IgG1⁺ plasma cell differentiation instead of class switching to IgE via Blimp1 expression. European Journal of Immunology. 2024. e2451041
Takeru Kashiwada, Ryotaro Takano, Fumihiko Ando, Shoko Kuroda, Yoshishige Miyabe, Ryuji Owada, Akihiko Miyanaga, Tomoko Asatsuma-Okumura, Masaaki Hashiguchi, Yoshikazu Kanazawa, et al. Lysosomal degradation of PD-L1 is associated with immune-related adverse events during anti-PD-L1 immunotherapy in NSCLC patients. Frontiers in Pharmacology. 2024. 15. 1384733
Fumihiko Ando, Takeru Kashiwada, Shoko Kuroda, Takenori Fujii, Ryotaro Takano, Yoshishige Miyabe, Shinobu Kunugi, Takashi Sakatani, Akihiko Miyanaga, Tomoko Asatsuma-Okumura, et al. Combination of plasma MMPs and PD-1-binding soluble PD-L1 predicts recurrence in gastric cancer and the efficacy of immune checkpoint inhibitors in non-small cell lung cancer. Frontiers in Pharmacology. 2024. 15. 13847
Sho Wakamatsu, Teruo Jojima, Masaaki Hashiguchi, Haruka Kishi, Takafumi Niitani, Shintaro Sakurai, Toshie Iijima, Takahiko Kogai, Takuya Tomaru, Isao Usui, et al. Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor. Journal of Diabetes and its Complications. 2024. 38. 1. 108650-108650
Hidefumi Kojima, Yuji Kashiwakura, Yumiko Kanno, Masaaki Hashiguchi, Tetsuji Kobata. Fine-tuning of antigen-specific immune responses by regulatory T cells activated via antigen recognition-independent and humoral factor-dependent mechanisms. Scandinavian Journal of Immunology. 2021. 93. 6. e13020

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MISC (6)：

B7 family molecules and the recently found function. Clinical immunology & allergology. 2007. 47. 6. 696-701
A.Sato, M. Hashiguchi, S. Hachimura, S. Kaminogawa. The role dendritic cells play in the cytokine response in Peyer's patches. 2001. 12. 331-335
上野川修一, 八村敏志, 後藤真生, 好田正, 橋口昌章, 上野川修一. 腸管免疫応答の特性. 日本農芸化学会誌. 1999. 73. 5. 523-527
上野川修一, 橋口昌章, 八村敏志, 上野川修一. 腸管におけるIgA産生とパイエル板T細胞のサイトカイン分泌. 臨床免疫. 1998. 30. 11. 1524-1531
八村敏志, 橋口昌章, 植田祥啓, 飴谷章夫, 佐藤健人, 熊谷善博, 垣生園子, 上野川修一. T細胞抗原レセプタートランスジェニックマウスを用いた経口投与抗原に対するT細胞応答の解析 : 食品. 日本農芸化学会誌. 1996. 70. 187-187

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Books (1)：

Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease
2010

Education (1)：

2000 - The University of Tokyo

Professional career (1)：

Ph.D (Univerty of Tokyo)

Work history (6)：

2021/04 - 現在 Nippon Medical School Institute for Advanced Medical Sciences
2020/04 - 2021/03 Dokkyo Medical University
2012/04 - 2020/03 Dokkyo Medical University School of Medicine
2010/04 - 2012/03 Dokkyo Medical University School of Medicine
2003/09 - 2010/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences

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