Hashiguchi Masaaki

ハシグチマサアキ | Hashiguchi Masaaki

Affiliation and department：

Research field (1)： Immunology

Research keywords (4)： IgA , IgE , innate lymphoid cells , mucosal immunity

Research theme for competitive and other funds (15)：

2022 - 2025 パイエル板Tfhによる抗体産生制御:対立遺伝子排除の破綻とアレルギーの抑制
2018 - 2021 Does IL-21 produced in Peyer's patch regulate the affinity of IgA and food allergy?
2015 - 2018 Peyer's patch immune cells regulates intestinal bacteria: basic research for the manipulation of intestinal bacteria by foods
2012 - 2015 Regulatory roles of HIF-1a and glycolysis in autoimmunity
2012 - 2015 Functional study of IL-5-producing cells in food allergy using GFP marking system

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Papers (38)：

Sho Wakamatsu, Teruo Jojima, Masaaki Hashiguchi, Haruka Kishi, Takafumi Niitani, Shintaro Sakurai, Toshie Iijima, Takahiko Kogai, Takuya Tomaru, Isao Usui, et al. Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor. Journal of Diabetes and its Complications. 2024. 38. 1. 108650-108650
Hidefumi Kojima, Yuji Kashiwakura, Yumiko Kanno, Masaaki Hashiguchi, Tetsuji Kobata. Fine-tuning of antigen-specific immune responses by regulatory T cells activated via antigen recognition-independent and humoral factor-dependent mechanisms. Scandinavian Journal of Immunology. 2021. 93. 6. e13020
Masaaki Hashiguchi, Yuji Kashiwakura, Yumiko Kanno, Hidefumi Kojima, Tetsuji Kobata. IL-21 and IL-5 coordinately induce surface IgA+ cells. Immunology Letters. 2020. 224. 21-27
Yuji Kashiwakura, Hidefumi Kojima, Yumiko Kanno, Masaaki Hashiguchi, Tetsuji Kobata. Heparin affects the induction of regulatory T cells independent of anticoagulant activity and suppresses the allogeneic immune responses. Clinical & Experimental Immunology. 2020
Hashiguchi M, Kashiwakura Y, Kojima H, Kanno Y, Kobata T. Peyer’s patches contain abundant isotype-switched B cells with activated phenotypes and are inductive sites for T-independent anti-DNA IgA. Immunology Letters. 2019. 211. 53-59

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MISC (6)：

B7 family molecules and the recently found function. Clinical immunology & allergology. 2007. 47. 6. 696-701
A.Sato, M. Hashiguchi, S. Hachimura, S. Kaminogawa. The role dendritic cells play in the cytokine response in Peyer's patches. 2001. 12. 331-335
上野川修一, 八村敏志, 後藤真生, 好田正, 橋口昌章, 上野川修一. 腸管免疫応答の特性. 日本農芸化学会誌. 1999. 73. 5. 523-527
上野川修一, 橋口昌章, 八村敏志, 上野川修一. 腸管におけるIgA産生とパイエル板T細胞のサイトカイン分泌. 臨床免疫. 1998. 30. 11. 1524-1531
八村敏志, 橋口昌章, 植田祥啓, 飴谷章夫, 佐藤健人, 熊谷善博, 垣生園子, 上野川修一. T細胞抗原レセプタートランスジェニックマウスを用いた経口投与抗原に対するT細胞応答の解析 : 食品. 日本農芸化学会誌. 1996. 70. 187-187

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Books (1)：

Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease
2010

Education (1)：

Professional career (1)：

Work history (6)：

2021/04 - 現在 Nippon Medical School Institute for Advanced Medical Sciences
2020/04 - 2021/03 Dokkyo Medical University
2012/04 - 2020/03 Dokkyo Medical University School of Medicine
2010/04 - 2012/03 Dokkyo Medical University School of Medicine
2003/09 - 2010/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences

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