Research theme for competitive and other funds (5)：
2022 - 2025 Elucidation of the gating mechanism of mechanosensitive channel by mechanical stimulation and amphipathic molecules
2020 - 2022 Molecular mechanisms of lipid-protein interactions focusing on tension-sensing amino acids
2017 - 2018 Activation mechanism of bacterial mechanosensitive channel of MscL by amphipath
2014 - 2017 Activation mechanism of Pannexin 1 channel by using patch-fluorometry
2010 - 2012 細菌機械受容チャネルのゲーティング機構の解明
Papers (33)：
Yasuyuki Sawada, Takeshi Nomura, Boris Martinac, Masahiro Sokabe. A novel force transduction pathway from a tension sensor to the gate in the mechano-gating of MscL channel. Frontiers in chemistry. 2023. 11. 1175443-1175443
Toshihiro Masuda, Kentarou Baba, Takeshi Nomura, Kazuya Tsujita, Tomo Murayama, Toshiki Itoh, Tomoka Takatani-Nakase, Masahiro Sokabe, Naoyuki Inagaki, Shiroh Futaki. An influenza-derived membrane tension-modulating peptide regulates cell movement and morphology via actin remodeling. Communications biology. 2019. 2. 243-243
Navid Bavi, Adam D. Martinac, D. Marien Cortes, Omid Bavi, Pietro Ridone, Takeshi Nomura, Adam P. Hill, Boris Martinac, Eduardo Perozo. Structural Dynamics of the MscL C-terminal Domain. SCIENTIFIC REPORTS. 2017. 7. 1. 17229-17229
清水 邦義, 永柄 真澄, 工藤 崇, 中島 大輔, 阿部 三佳, 吉村 友里, 小山 眞, 野村 健, 大貫 宏一郎. 自然の香りの空間におけるヒトの睡眠改善効果-Effect of natural fragrance environments on human sleep improvement-特集 香りが睡眠にもたらすもの : 研究の最前線. Aroma research = アロマリサーチ : journal of aroma science technology and safety. 2019. 20. 3. 217-223
Sawada Yasuyuki, Nomura Takeshi, Sokabe Masahiro. 1P033 Mechanosensor and gate is tightly coupled in the opening process of the bacterial mechanosensitive channel MscL(01B. Protein:Structure & Function,Poster). Seibutsu Butsuri. 2013. 53. 1. S111
Nomura Takeshi, Sokabe Masahiro, Martinac Boris. 1P224 The orientation of MscS in liposomal membranes(13C. Biological & Artifical membrane: Excitation & Channels,Poster). Seibutsu Butsuri. 2013. 53. 1. S143
Nomura Takeshi, Yoshimura Kenjiro, Sokabe Masahiro. Modulation of the activity of mechanosensitive channel MscL by chlorpromazine. Proceedings of Annual Meeting of the Physiological Society of Japan. 2008. 2008. 085-085
Mechanosensitivity of Ion Channels
Springer, Encyclopedia of Biophysics 2018
Techniques for Investigating the Mechanosensitivity of Ion Channels
Springer, Encyclopedia of Biophysics 2013
Patch clamp electrophysiology for the study of bacterial ion channels in giant spheroplasts of E. coli
Springer, Methods Mol Biol 2013
Force from lipids: A multidisciplinary approach to study bacterial mechanosensitive ion channels. In Mechanically Gated Channels and their Regulation
Springer, Mechanically Gated Channels and their Regulation 2012
Lectures and oral presentations (33)：
Analysis on the role of the periplasmic loop of the bacterial mechanosensitive channel MscL
(第21回国際生物物理会議及び第62回日本生物物理学会合同年会 2024)
Differential roles of a periplasmic tension sensor and a cytoplasmic one in the channel opening of MscL
(第21回国際生物物理会議及び第62回日本生物物理学会合同年会 2024)
Current-direcion/amplitude-dependent single channel gating kinetics of Pannexin 1 channel
(International Symposium on Ion Channels, Transporters and Signal Transduction,(Kyoto) 2016)
Single-channel gating kinetic analysis of mouse pannexin 1 channel
(The 2nd International Symposium on Epithelial Barrier and Transport(Shiga, Japan) 2014)
