Rchr

J-GLOBAL ID：201801015062570062 Update date: Feb. 28, 2024

Naruse Keiji

ナルセケイジ | Naruse Keiji

Affiliation and department：

Research field (1)： Biomedical engineering

Research keywords (2)： Biomedical Engineering , Physiology

Research theme for competitive and other funds (60)：

2021 - 2024 新規メカニカル負荷装置の開発を通した次世代メカノメディスンへの挑戦
2020 - 2024 機械感受性チャネルPiezo1とメカノセンサーを標的とした呼吸器疾患の病態解明
2020 - 2023 Investigation of NOX4-mediated mechanotransduction in mechanically-induced cardiac failure
2020 - 2022 微小重力下では細胞はどのような挙動をするのか?
2018 - 2021 メカニカルストレス負荷システムの開発

2015 - 2020 Integral Understanding of Life-regulation Mechanism from "SPACE"

2015 - 2020 Mechanosensing Mechanisms for Sensing Mechanical Stress Including Gravitational Changes

2020 - 2020 がん組織に分布する感覚神経に着目した、がんの新規バイオマーカーと新規がん神経治療の開発

2017 - 2019 Study on biological response to high hydrostatic pressure

2014 - 2019 Mechanomedicine: Application of mechanobiological engineering to regenerative and reproductive medicine

2014 - 2017 Development of analytical systems for mouse embryos applied with mechanical stimuli

2014 - 2017 Mechanobiology of tumor interstitial fluid pressure, angiogenesis, lymphangiogenesis, and Extracellular Matrix (ECM)

2014 - 2017 Role of reactive oxygen species in physiology and pathophysiology of cardiac biomechanics

2014 - 2017 Integrated analysis of microRNAs that regulate cartilage damage and its functional analysis in chondrocytes

2014 - 2017 The effect of stretch stimuli on human skin equivalents

2012 - 2016 The prospective study for the effects of culture-expanded bone marrow cells on the regeneration bone.

2014 - 2015 心疾患治療に向けた革新的次世代メカノ組織工学・再生医療の創生

2013 - 2015 Development of the preparing method of three dimensional cartilage tissue by taking advantage of mechanical medical engineering technology

2012 - 2015 Mechanical stretch on Human skin equivalents with a new peptide scaffold

2012 - 2014 TRPV4, a Ca ion channel plays pivotal role in chondrogenic mechanotransduction in ATDC5

2012 - 2014 neuranagenesis within a self-assembling peputide gel

2011 - 2014 Physiomic analyses of cardiac hypertrophy and ventricular geometry of in cardiac regulation

2011 - 2014 role of mechanosensitive response of organelle in dynamic biomechanics of cardiomyocytes

2011 - 2014 Regulatory mechanism of transcriptional factors and microRNA in arthritis

2011 - 2013 ADAMTS1 metalloproteinase inhibits lymphangiogenesis and mechanobiology of lymphangiogenesis

2011 - 2012 Development of a three dimensional stretchcell culture system with a self-assembling peptide scaffold

2010 - 2012 Elucidation of Biological Adaptation and Remodeling Mechanisms to Mechanical Stress Based on the Development of Novel Micro-Electro-Mechanical Systems (MEMS) technology

2009 - 2011 Study on interactions of proteins/peptides disrupting cell membranes with lipid membranes using the single giant unilamellar vesicle method

2009 - 2011 マルチレベル医工学評価法に基づく心筋メカノセンサーの作動機序と病態生理的役割

2009 - 2010 医工学的解析に基づく肺ストレッチセンサーを介した肺癌発症機構の解明

2008 - 2010 Aggrecanase regulation system in osteoarthritis and strategy for early diagnosis and therapy for osteoarthritis

2008 - 2010 Role of mechanical load in human myocardial excitation contraction coupling

2008 - 2010 Coronary Circulation-Cardiac Mechanics Coupling

2007 - 2009 The role of mechanosensor on cardiovascular disease.

2005 - 2009 Application of Soft Lithography to Mechanobiology

2007 - 2008 Novel mechanism of abnormal intracellular Ca2+ handling in heart failure

2007 - 2008 未熟児網膜症におけるヘモグロビン変換の関与

2007 - 2008 生体血管膜モデルを用いた血管新生・消退機構の統合的解析

2007 - 2008 Search for the molecular entities of muscarine receptor-operated non-selective cation channels and their regulatory system

2004 - 2008 Creation of Mechanobiology Based on Mechanosensitive Channels

2006 - 2007 Inducible mechanism and role of novel aggrecanase in early stage of arthritis and its therapeutic application

2005 - 2006 長期継代培養細胞を用いた視細胞イオンチャネル異常疾患研究のための実験系構築

2005 - 2006 新規微量プロテインフォスファターゼ群の分子クローニングと機能解析

2005 - 2006 Concept and Development of The Optically Driven Nanomechatronics

2004 - 2005 軟骨細胞に最適化したバイオリアクターの開発

2003 - 2004 チャネル病としての緑内障への分子生物学的アプローチ

2003 - 2004 Development of the nano device for medical use based on the Biochemical IC

2001 - 2003 STUDY ON THE STRUCTURE FUNCTION AND PHYSIOLOGICAL ROLES OF SA CHANNELS

2001 - 2002 Molecular-biological approach to the regulatory mechanism of ciliary muscle contraction

2001 - 2002 DEVELOPMENT OF BIOCHEMICAL IC CHIPS

2001 - 2002 Analysis of a newly cloned stretch-activated ion channel from cardiac cells

2001 - 2001 高速単一細胞伸展装置の開発

2001 - 2001 チャネル病としての緑内障への分子生物学的研究法導入

1999 - 2000 機械受容機構の解明-メカノリセプターの分子実体は何か-

1997 - 1998 STUDY ON THE DEVELOPMENT OF MOLECULAR BIOLOGY AND PHYSIOLOGY OF SA CHANNELS

1997 - 1998 血管内皮細胞の機械刺激受容機構の解明

1997 - 1997 伸展刺激による血管内皮細胞リモデリングの分子機構

1996 - 1996 血管内皮細胞の機械刺激受容応答機構の研究

1995 - 1996 血管内皮細胞における機械受容チャネルの研究

1994 - 1994 血管内皮細胞における機械受容チャネルの研究

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Papers (192)：

Mengxue Wang, Harumi Idei, Chen Wang, Yin Liang, Yun Liu, Yusuke Matsuda, Ken Takahashi, Hiroshi Kamioka, Keiji Naruse. Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts. 2023
Nalinrat Petpiroon, Woranan Netkueakul, Kanokwan Sukrak, Chen Wang, Yin Liang, Mengxue Wang, Yun Liu, Qiang Li, Rumaisa Kamran, Keiji Naruse, et al. Development of lung tissue models and their applications. Life Sciences. 2023. 334. 122208-122208
Kaihara K, Kai H, Chiba Y, Naruse K, Iribe G. Stretch-induced reactive oxygen species contribute to the Frank-Starling mechanism. The Journal of Physiology. 2023
Yamaguchi Y, Nishiyama M, Kai H, Kaneko T, Kaihara K, Iribe G, Takai A, Naruse K, Morimatsu M. High hydrostatic pressure induces slow contraction in mouse cardiomyocytes. Biophysical Journal. 2023. 122. 1. 267-267
Takahashi K, Liu Y, Wang M, Liang Y, Naruse K. Live imaging of nitric oxide release in vascular endothelial cells in response to mechanical stimuli on an organ chip. European Heart Journal. 2022. 43. Supplement_22

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MISC (116)：

森松賢順, 西山雅祥, 成瀬恵治. 高圧刺激下での細胞動態の可視化. 日本生体医工学会大会プログラム・抄録集(Web). 2022. 61st
Shiraishi Y, Sakuma I, Naruse K, Ueno A. 11th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings. 2021. 82
成瀬恵治. 第59回日本生体医工学会大会開催報告. 岡山医学会雑誌. 2020. 132. 110-111
Naruse K. Mechanomedicine. Biophysical reviews. 2018
高橋賢, 佐々並三紗, 長田仁, 成瀬恵治. 特集:宇宙の極限環境から生命体の可塑性をさぐる--1.重力変動の生理機能への影響細胞の重力応答機構--. 生体の科学. 2018. 69. 2. 106-109

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Patents (2)：

心筋細胞の作製方法
遠心顕微鏡

Books (25)：

Dynamic remodeling of the heart and blood vessels: implications of health and disease.
Blackwell Publishing 2017
Innovation of vascular engineering by mechanomedicine.
Springer 2016
第20章生殖工学のバイオメカニクス:生理学/メカニクス/治療
(株)化学同人 2015
メカノバイオロジーを駆使した新システムで、再生医療・不妊治療に福音を.
アドスリー出版 2013
Recent Advances in Mechanobiology
Shanghai scientific and technological literature publishing house 2012

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Lectures and oral presentations (522)：

メカノメディスン:深海から宇宙まで
(第30回日本未病学会学術総会 2023)
臓器チップ上の血管内皮細胞におけるメカニカルストレス誘発性一酸化窒素放出のライブイメージング系の開発
(第17回日本臨床ストレス応答学会大会)
Hydrostatic pressure stimuli increase intracellular calcium concentration
(第61回日本生物物理学会年会)
Mechanomedicine
(Second China-Japan Symposium on Medical Exchange 2023)
Microfluidic culture of highly barrier-functional endothelial cells: mimicking in vivo vascular environment for organ chip applications
(生体医工学シンポジウム2023)

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Education (2)：

1988 - 1992 Nagoya University
- 1988 Nagoya University School of Medicine

Professional career (1)：

博士(医学) (名古屋大学)

Work history (12)：

2023/04 - 現在 Okayama University
2023/04 - 現在 Okayama University
2023/04 - 現在 Okayama University
2023/04 - 現在 Okayama University
2023/04 - 現在 Okayama University

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Committee career (9)：

2023/04 - 現在公益社団法人日本生体医工学会中国四国支部長
2022/06 - 現在 IAMBE Fellows
2021/04 - 現在岡山県医師会(産業保健担当理事)
2021/04 - 現在岡山医学会幹事
2020/03 - 現在一般社団法人日本生理学会副理事長

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Awards (14)：

2022/10 - 第45回日本生体医工学会中国四国支部大会最優秀若手講演奨励賞ヒト単離心筋細胞における長さ張力関係を用いた力学機能評価
2019/12 - 2019 International Conference for Leading and Young Medical Scientists 1th prize in poster presentation Role of the TRPM4 channel in mitochondrial function, ROS generation, and calcium release in myocardial ischemia-reperfusion injury.
2019/10 - 第42回日本生体医工学会中国四国支部大会若手講演奨励賞心筋バイオメカニクス制御におけるプリン作動性シグナリングの役割
2019/06 - 第58回日本生体医工学会 Young Investigator’s Award 周期的伸展刺激と静水圧刺激に対するヒト歯根膜細胞の形態と配向の変化
2018/06 - 第57回日本生体医工学会 Young Investigator’s Award 高圧下での細胞動態イメージング

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Association Membership(s) (10)：

日本分子生物学会 , 日本生理学会 , 日本生物物理学会 , 日本産科婦人科学会 , 日本医史学会 , 日本生体医工学会 , 岡山県医用工学研究会 , Biophysical Society , The American Society for Cell Biology , American Society for Reproductive Medicine

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