2017 - 2019 Study on biological response to high hydrostatic pressure
2014 - 2019 Mechanomedicine: Application of mechanobiological engineering to regenerative and reproductive medicine
2014 - 2017 Integrated analysis of microRNAs that regulate cartilage damage and its functional analysis in chondrocytes
2014 - 2017 The effect of stretch stimuli on human skin equivalents
2014 - 2015 心疾患治療に向けた革新的次世代メカノ組織工学・再生医療の創生
2013 - 2015 Development of the preparing method of three dimensional cartilage tissue by taking advantage of mechanical medical engineering technology
2012 - 2015 Mechanical stretch on Human skin equivalents with a new peptide scaffold
2012 - 2014 TRPV4, a Ca ion channel plays pivotal role in chondrogenic mechanotransduction in ATDC5
2012 - 2014 neuranagenesis within a self-assembling peputide gel
2011 - 2014 Physiomic analyses of cardiac hypertrophy and ventricular geometry of in cardiac regulation
2011 - 2014 role of mechanosensitive response of organelle in dynamic biomechanics of cardiomyocytes
2011 - 2014 Regulatory mechanism of transcriptional factors and microRNA in arthritis
2011 - 2013 ADAMTS1 metalloproteinase inhibits lymphangiogenesis and mechanobiology of lymphangiogenesis
2011 - 2012 Development of a three dimensional stretchcell culture system with a self-assembling peptide scaffold
2010 - 2012 Elucidation of Biological Adaptation and Remodeling Mechanisms to Mechanical Stress Based on the Development of Novel Micro-Electro-Mechanical Systems (MEMS) technology
2009 - 2011 Study on interactions of proteins/peptides disrupting cell membranes with lipid membranes using the single giant unilamellar vesicle method
2007 - 2009 The role of mechanosensor on cardiovascular disease.
2005 - 2009 Application of Soft Lithography to Mechanobiology
2007 - 2008 Novel mechanism of abnormal intracellular Ca2+ handling in heart failure
2007 - 2008 未熟児網膜症におけるヘモグロビン変換の関与
2007 - 2008 生体血管膜モデルを用いた血管新生・消退機構の統合的解析
2007 - 2008 Search for the molecular entities of muscarine receptor-operated non-selective cation channels and their regulatory system
2004 - 2008 Creation of Mechanobiology Based on Mechanosensitive Channels
2006 - 2007 Inducible mechanism and role of novel aggrecanase in early stage of arthritis and its therapeutic application
2005 - 2006 長期継代培養細胞を用いた視細胞イオンチャネル異常疾患研究のための実験系構築
2005 - 2006 新規微量プロテインフォスファターゼ群の分子クローニングと機能解析
2005 - 2006 Concept and Development of The Optically Driven Nanomechatronics
2004 - 2005 軟骨細胞に最適化したバイオリアクターの開発
2003 - 2004 チャネル病としての緑内障への分子生物学的アプローチ
2003 - 2004 Development of the nano device for medical use based on the Biochemical IC
2001 - 2003 STUDY ON THE STRUCTURE FUNCTION AND PHYSIOLOGICAL ROLES OF SA CHANNELS
2001 - 2002 Molecular-biological approach to the regulatory mechanism of ciliary muscle contraction
2001 - 2002 DEVELOPMENT OF BIOCHEMICAL IC CHIPS
2001 - 2002 Analysis of a newly cloned stretch-activated ion channel from cardiac cells
2001 - 2001 高速単一細胞伸展装置の開発
2001 - 2001 チャネル病としての緑内障への分子生物学的研究法導入
1999 - 2000 機械受容機構の解明-メカノリセプターの分子実体は何か-
1997 - 1998 STUDY ON THE DEVELOPMENT OF MOLECULAR BIOLOGY AND PHYSIOLOGY OF SA CHANNELS
1997 - 1998 血管内皮細胞の機械刺激受容機構の解明
1997 - 1997 伸展刺激による血管内皮細胞リモデリングの分子機構
1996 - 1996 血管内皮細胞の機械刺激受容応答機構の研究
1995 - 1996 血管内皮細胞における機械受容チャネルの研究
1994 - 1994 血管内皮細胞における機械受容チャネルの研究
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Papers (174):
Nagao K, Yoshikawa S, Urakami H, Fujita Y, Komura A, Nakashima M, Oh-Hora M, Fujimura A, Hiyama TY, Naruse K, et al. Ligand-independent function of β2-adrenergic receptor affects IgE-mediated Ca2+ influx in mast cells. Biochemical and Biophysical Research Communications. 2024. 733. 150595-150595
Yamada H, Osaka H, Tatsumi N, Araki M, Abe T, Kaihara K, Takahashi K, Takashima E, Uchihashi T, Naruse K, Takei K. Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes. Cells. 2024. 13. 16. 1373-1373
Liu Y, Kamran R, Han X, Wang M, Li Q, Lai D, Naruse K, Takahashi K. Human heart-on-a-chip microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes. Scientific Reports. 2024. 14. 1. 18063
Xu S, Inoue M, Yoshimura Y, Kondoh K, Naruse K, Hiyama TY. Celiac and superior mesenteric ganglia removal improves glucose tolerance and reduces pancreas islet size. Neuroscience Letters. 2024. 837. 137919-137919
Wang M, Idei H, Wang C, Liang Y, Liu Y, Matsuda Y, Takahashi K, Kamioka H, Naruse K. Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts. 2023
2019/12 - 2019 International Conference for Leading and Young Medical Scientists 1th prize in poster presentation Role of the TRPM4 channel in mitochondrial function, ROS generation, and calcium release in myocardial ischemia-reperfusion injury.
2019/06 - 第58回日本生体医工学会 Young Investigator’s Award 周期的伸展刺激と静水圧刺激に対するヒト歯根膜細胞の形態と配向の変化
2018/06 - 第57回日本生体医工学会 Young Investigator’s Award 高圧下での細胞動態イメージング
2017/09 - 第55回日本生物物理学会年会 日本生物物理学会学生発表賞 Medicine, Dentistry and Pharmaceutical Sciences Effects of Mechanical Stress on Remodeling of Periodontal Ligament
2016/03 - The 93nd Annual Meeting of the Physiological Society of Japan 学生ポスター賞 TRPC3 contributes to a slow force response to stretch on mice cardiomyocytes.
2012/01/07 - 38th Annual Conference of the IETS outstanding presentation Comparison between static and dynamic culture results using a novel air actuation system.
2011/11/06 - International Symposium on Micro-NanoMechanotronics and Human Science (MHS2011) IEEE, Best Paper Award in 2011 Development of Observation System to Investigate both Intracellular Calcium Concentration and Mechanical Stimuli to Mammalian Embryos.
2005/11/07 - International Symposium on Micro-NanoMechanotronics and Human Science (MHS2005) IEEE, Best Paper Award in 2005 Application of Soft Lithography to Mechanobiology
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Association Membership(s) (10):
日本分子生物学会
, 日本生理学会
, 日本生物物理学会
, 日本産科婦人科学会
, 日本医史学会
, 日本生体医工学会
, 岡山県医用工学研究会
, Biophysical Society
, The American Society for Cell Biology
, American Society for Reproductive Medicine