Rchr
J-GLOBAL ID：201801015155470297   Update date: Sep. 27, 2024

Ajiro Masahiko

アジロ マサヒコ | Ajiro Masahiko
Affiliation and department：
National Cancer Center Research Institute Division of Cancer RNA Research, National Cancer Center Research Institute

About National Cancer Center Research Institute Division of Cancer RNA Research, National Cancer Center Research Institute


Job title： Principal Investigator
Research field  (5)： Systems genomics ,  Molecular biology ,  Genomics ,  Tumor biology ,  Medical biochemistry
Research theme for competitive and other funds  (5)：
  • 2024 - 2029 Full-length transcriptome analysis for bladder cancer
  • 2024 - 2027 Onco-exaptationの検出基盤形成と臨床応用性の検証
  • 2023 - 2027 Cancer immune therapeutics targeting aberrant RNA splicing products
  • 2019 - 2022 Functional study for CLK-dependent pseudo exon in genetic diseases
  • 2015 - 2020 Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models
Papers (35)：
  • Kazuki Nishimura, Kiyoshi Takahara, Kazumasa Komura, Mitsuaki Ishida, Kensuke Hirosuna, Ryoichi Maenosono, Masahiko Ajiro, Moritoshi Sakamoto, Kengo Iwatsuki, Yuki Nakajima, et al. Mechanistic insights into lethal hyper progressive disease induced by PD-L1 inhibitor in metastatic urothelial carcinoma. NPJ precision oncology. 2024. 8. 1. 206-206
  • Naoko Yano, Pin Fee Chong, Kenji K Kojima, Tomoichiro Miyoshi, Ahmad Luqmen-Fatah, Yu Kimura, Kengo Kora, Taisei Kayaki, Kanako Maizuru, Takahiro Hayashi, et al. Long-read sequencing identifies an SVA_D retrotransposon insertion deep within the intron of ATP7A as a novel cause of occipital horn syndrome. Journal of Medical Genetics. 2024. 61. 10. 950-958
  • Mamiko Yamada, Kazuhiro Maeta, Hisato Suzuki, Ryo Kurosawa, Toshiki Takenouchi, Tomonari Awaya, Masahiko Ajiro, Atsuko Takeuchi, Hisahide Nishio, Masatoshi Hagiwara, et al. Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration. Scientific Reports. 2024. 14. 1
  • Kazumasa Komura, Kensuke Hirosuna, Satoshi Tokushige, Takuya Tsujino, Kazuki Nishimura, Mitsuaki Ishida, Takuo Hayashi, Ayako Ura, Takaya Ohno, Shogo Yamazaki, et al. The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer. Molecular cancer. 2023. 22. 1. 185-185
  • Ryo Kurosawa, Kei Iida, Masahiko Ajiro, Tomonari Awaya, Mamiko Yamada, Kenjiro Kosaki, Masatoshi Hagiwara. PDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing. BMC Genomics. 2023. 24. 1
ｍore...
Books (8)：
  • RNA標的創薬技術開発の最先端
    情報機構 2024
  • Application of splice-neoantigen for cancer immune therapy
    2023
  • 遺伝子発現の基本性質から遺伝性疾患・治療方法まで
    mRNAの制御機構の解明と治療薬・ワクチンへの活用(技術情報協会) 2023
  • 遺伝子発現機構から考える遺伝子コントロール:スプライシング異常による発がん機構の解明
    mRNAの制御機構の解明と治療薬・ワクチンへの活用(技術情報協会) 2023
  • RNAスプライシング制御を標的とした創薬
    生化学(日本生化学会) 2022
ｍore...
Lectures and oral presentations  (8)：
  • RNAスプライシング異常のがん免疫への寄与
    (第28回日本がん免疫学会総会・第37回日本バイオセラピィ学会学術集会総会 合同大会)
  • Cancer immunotherapy targeting aberrant RNA splicing regulation
    (The 82nd Annual Meeting of Japanese Cancer Association)
  • スプライス・ネオ抗原の探索
    (2022)
  • Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.
    (The 44th Annual Meeting of MBSJ, workshop: Getting to the crux of gene expression mechanisms through chemical biology)
  • Amending splicing defects by small molecule compounds
    (MBSJ2020 workshop: Pathogenic defect and chemical manipulation of RNA processing)
ｍore...
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (8)：
  • 2023/04 - 現在 National Cancer Center Research Institute Division of Cancer RNA Research
  • 2022/01 - 2023/03 京都大学大学院 医学系研究科 創薬医学講座 特定講師
  • 2016/05 - 2021/12 Kyoto University Graduate School of Medicine, Department of Drug Discovery Medicine Assistant Professor
  • 2012/01 - 2016/04 National Cancer Institute/NIH Gene Regulation and Chromosome Biology Laboraroty Visiting Fellow
  • 2013/03 - 2015/02 Japan Society of Promotion of Sciences Postdoctoral Researcher in Foreign Country
Show all
Awards (5)：
  • 2024/09 - Takeda Science Foundation Grant for Mecial Research
  • 2015/12 - The Molecular Biology Society of Japan, The Japanese Biochemical Society Travel Grant for annual meeting of the 38th MBSJ and the 88th JBS
  • 2015/12 - Kanzawa Medical Research Foundation The 18th Grant for Research Abroad
  • 2013/11 - National Cancer Institute/NIH, Center of Excellence in HIV/AIDS and Cancer Virology Think Tank Travel Award
  • 2009/12 - Kanzawa Medical Research Foundation The 12th Grant for Research Abroad
Association Membership(s) (5)：
Japanese Association of Cancer Immunology ,  Japanese RN Society ,  Japanese Cancer Association ,  The Molecular Biology Society of Japan ,  American Association of Cancer Research
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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