Nakanishi Tadashi

Research field (1)： Conservative dentistry and endodontics

Research theme for competitive and other funds (29)：

2022 - 2026 ワサビ含有成分を歯周炎治療に用いるための基礎的研究~抗炎症作用に着目して~
2022 - 2026 乳酸菌由来細胞外小胞を用いた歯周病治療戦略ーM1/M2マクロファージに着目してー
2019 - 2022 Basic study of the bioactive substances of a skin of citrus fruits for periodontal disease treatment
2018 - 2021 香辛料含有成分を歯周炎治療に用いるための基礎的研究-ローズマリーに着目して-
2017 - 2020 初期の歯髄炎における象牙芽細胞の石灰化と生体防御機構の解明

2017 - 2020 Development of a new approach to the treatments in conservative dentistry based on a concept for home or visit care.

2016 - 2019 歯周炎病変局所における炎症性骨吸収に関与する白血球浸潤機構の解析

2015 - 2018 歯周病におけるメラトニンの役割解明および治療への応用

2015 - 2018 エピジェネティクス・転写後発現調節機構の解析による新規歯髄温存・石灰化療法の開発

2015 - 2018 自然免疫を介した象牙芽細胞石灰化メカニズムの解明

2015 - 2018 歯髄炎における炎症・抗炎症バランス制御機構の解析とTh17細胞の役割

2014 - 2017 Application of electromagnetic wave irradiation to deep caries lesion.

2013 - 2016 Analysis of Th17 cells migration and activation in periodontally diseased tissues

2012 - 2015 Development of extracellular DNA-protein complex-targeting novel treatments and prevention for oral biofilm-related infectious diseases

2012 - 2015 Analysis of a balance between pro-inflammatory and anti-inflammatory pulpal responses in the pathogenesis of pulpitis

2011 - 2014 Development of a new comprehensive treatment for dental caries based on minimum intervention dentistry

2009 - 2012 Endodontic therapeutic application of electro-magnetic wave irradiation for refractory periapical periodontitis and periapical biofilm

2008 - 2011 Study on a therapeutic application of tea catechins to vital pulp treatment.

2006 - 2008 Analysis of bacterial invasive lesion of refractory periapical periodontitis cases by genetic engineering technique

2003 - 2005 Analysis of gingival epithelial cells and fibroblast using three-dimensional culture system mimic to periodontal pockets

2001 - 2003 Study on the role of chemokines in the infiltration of inflammatory cells in dental pulp tissue destruction

1999 - 2001 Analysis of the relationship between the invasion of dental caries-associated bacteria and the host response of dental pulp in human carious teeth with pulp exposure

1998 - 2000 Bacterial Invasion of Infected Canals and Root Dentin of Human Teeth and Analysis of the Host-parasite Interaction at the Apex. - Elucidation of Pathogenesis of Refractory Cases-.

1996 - 1997 歯髄組織破壊における多形核白血球浸潤の細胞傷害性に関する研究

1996 - 1997 ヒト歯周炎における炎症浸潤細胞の接着機構の研究

1995 - 1996 多形核白血球の集積化による歯髄組織破壊機構の解析

1994 - 1995 歯髄血液を用いた不可逆性歯髄炎の診断に関する研究

1994 - 1995 歯周組織破壊の進行過程における免疫担当細胞の動態

1992 - 1993 歯髄炎の非可逆性化に関与する炎症機構の解析

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Papers (35)：

Hitomi Kuramoto, Tadashi Nakanishi, Daisuke Takegawa, Katsuhiro Mieda, Keiichi Hosaka. Caffeic Acid Phenethyl Ester Induces Vascular Endothelial Growth Factor Production and Inhibits CXCL10 Production in Human Dental Pulp Cells. Current Issues in Molecular Biology. 2022. 44. 11. 5691-5699
Hitomi Kuramoto, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Tadashi Nakanishi, Daisuke Takegawa, Ayako Washio, Chiaki Kitamura, Takashi Matsuo. Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells. BioMed Research International. 2019. 2019. 1-12
松尾敬志, 中西正. 深在性う蝕への対応と歯髄の免疫応答. 日本歯科保存学会誌. 2019. 61. 1. 1-7
Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi Matsuo. The roles of odontoblasts in dental pulp innate immunity. Japanese Dental Science Review. 2018. Vol.54. No.3. 105-117
Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Hitomi Kuramoto, 鷲尾絢子, Tadashi Nakanishi, Daisuke Takegawa, 北村知昭, Takashi Matsuo. ラット象牙芽細胞様細胞 (KN-3) におけるカテキンの抗炎症作用. The Japanese Journal of Conservative Dentistry. 2017. Vol.60. No.5. 235-244

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MISC (9)：

蔵本瞳, 中西正. 歯髄炎治療におけるカフェイン酸フェネチルエステル応用の可能性. メディカルサイエンスダイジェスト. 2022. 48. 11. 48-49
Tadashi Nakanishi, Takashi Matsuo. 感染根管における細菌感染の実態. The Nippon Dental Review. 2017. Vol.77. No.11. 45-58
Takashi Matsuo, Tadashi Nakanishi. 歯髄炎の病態形成における細菌侵襲と歯髄の反応性. The Nippon Dental Review. 2013. Vol.73. No.6. 9-11
Takashi Matsuo, Kazumi Ozaki, Tadashi Nakanishi, Hiromichi Yumoto, Kanako Takahashi, Kouji Hirao, Daisuke Takegawa. Pulp pathosis and its diagnosis. 日本歯内療法学会雑誌. 2013. Vol.34. No.2. 67-76
Tadashi Nakanishi. 歯髄炎の病態形成における細菌侵襲と歯髄の反応性. The Japanese Journal of Conservative Dentistry. 2010. Vol.53. No.5. 489-491

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Books (5)：

感染根管治療Retreatment : 感染制御の要点を知る 2感染根管における細菌感染の実態
ヒョーロン・パブリッシャーズ 2019 ISBN:9784864320511
第17章高齢者・有病者の歯内治療
医歯薬出版株式会社 2018
第1章歯と歯根周囲の組織学
永末書店 2018
新・歯科衛生士教育マニュアル保存修復 5 歯髄の保護法
Quintessence Publishing CO.,Ltd. 2012
Proceedings of the International Conference on Dentin/Pulp Complex 2001
Quintessence Publishing CO.,Ltd. 2002

Lectures and oral presentations (30)：

Effect of catechins on cytokine production in human dental pulp cells
(2008)
Expression of Cytokines and Adhesion Molecules in Cultured Dental Pulp Fibroblasts Affected by Bacteria-derived Factors
(2007)
Expression of Cellular Adhesion Molecules via Pattern Recognition Receptor in Cultured Pulp Cells
(2007)
Catechin modulates the responses of cultured pulp cell stimulated with bacteria or bacterial components
(2007)
Expression of macrophage inflammatory Protein-3alpha/CCL20 in human gingival epithelial cells.
(JOURNAL OF DENTAL RESEARCH 2003)

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Committee career (2)：

2018/11 - 現在日本歯内療法学会編集委員
2001/04/01 - 現在日本歯科保存学会評議員

Association Membership(s) (5)：

Japanese Society for Immunology , International Association for Dental Research , The Japanese Society of Periodontology , The Japanese Society of Conservative Dentistry , 日本歯内療法学会

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