Rchr
J-GLOBAL ID：201801015797548869   Update date: May. 22, 2024

Yamashita Tomohiro

ヤマシタ トモヒロ | Yamashita Tomohiro
Affiliation and department：
Kyushu University Department of Drug Discovery Structural Biology, Graduate School of Pharmaceutical Sciences

About Kyushu University Department of Drug Discovery Structural Biology, Graduate School of Pharmaceutical Sciences


Job title： Lecturer
Research field  (3)： Neuroscience - general ,  Clinical pharmacy ,  Pharmacology
Research keywords  (15)： 慢性掻痒 ,  創薬薬理学 ,  high-throughput screening ,  chemical screening ,  MRGPRs ,  Mrgpr ,  pain ,  itch ,  P2X4R ,  purinergic receptor ,  microglia ,  glia ,  GPCR ,  drug discovery ,  pharmacology
Research theme for competitive and other funds  (13)：
  • 2022 - 2025 Development of cancer immunotherapy using non-receptor type immune checkpoint inhibitor targeting PTPN3
  • 2021 - 2024 Improvement of protein expression by Escherichia coli based on the structure of anti-P2X4 antibody Fab and development of its additional function.
  • 2021 - 2024 かゆみ伝達に対するMRGPRの包括的研究および創薬シーズの探索
  • 2019 - 2024 Elucidation of abnormal functioning of neuronal circuits underlying neuropathic pain and its application for drug discovery
  • 2017 - 2022 グリーンファルマを基盤にした創薬オープンイノベーションの推進
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Papers (27)：
  • Ryota Mori, Masami Abe, Yuma Saimoto, Saki Shinto, Sara Jodai, Manami Tomomatsu, Kaho Tazoe, Minato Ishida, Masataka Enoki, Nao Kato, et al. Construction of a screening system for lipid-derived radical inhibitors and validation of hit compounds to target retinal and cerebrovascular diseases. Redox biology. 2024. 73. 103186-103186
  • Yuya Yoshida, Kohei Fukuoka, Miyu Sakugawa, Masayuki Kurogi, Kengo Hamamura, Keika Hamasaki, Fumiaki Tsurusaki, Kurumi Sotono, Takumi Nishi, Taiki Fukuda, et al. Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment. Translational research : the journal of laboratory and clinical medicine. 2024
  • Marie Taniguchi, Sai Yasukochi, Wakaba Yamakawa, Yuya Tsurudome, Akito Tsuruta, Michiko Horiguchi, Kentaro Ushijima, Tomohiro Yamashita, Naoya Shindo, Akio Ojida, et al. Inhibition of tumor-derived CCL2 expression attenuates tactile allodynia in NCTC 2472 fibrosarcoma-inoculated mice. Molecular pharmacology. 2023
  • 大野 瑛明, 山下 智大, 狩野 航輝, 岩渕 和久, 平林 義雄, 松尾 一郎, 上口 裕之, 中島 康晴, 津田 誠. GPR55は脊柱管狭窄に伴う下肢痛の発症と好中球の浸潤に寄与する. Journal of Spine Research. 2023. 14. 3. 528-528
  • Teruaki Ono, Tomohiro Yamashita, Ryota Kano, Mariko Inoue, Shota Okada, Koki Kano, Schuichi Koizumi, Kazuhisa Iwabuchi, Yoshio Hirabayashi, Ichiro Matsuo, et al. GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice. Brain, behavior, and immunity. 2023. 110. 276-287
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MISC (8)：
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Lectures and oral presentations  (5)：
  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury WCP2018
    (WCP2018 2018)
  • New pharmacological effects of approved drugs targeting P2X7 receptors against the release of IL-1β from microglial cells and neuropathic pain after peripheral nerve injury
    (Purines 2018 2018)
  • Microglial ATP receptors in neuropathic pain
    (Purines 2018 2018)
  • グリア細胞およびATP受容体を標的としたアカデミア創薬の実現に向けた「グリーンファルマ研究」の取り組み
    (薬学会137年会 2017)
  • デュロキセチンによるミクログリアに発現するP2X4受容体の阻害作用および末梢神経損傷に伴う神経障害性疼痛に対する改善効果
    (第90回日本薬理学会年会 2017)
Professional career (1)：
  • 薬学博士 (九州大学)
Association Membership(s) (3)：
THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPANESE PHARMACOLOGICAL SOCIETY
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