Rchr
J-GLOBAL ID：201801015877588314
Update date: May. 13, 2024
Hayashi Takeru
ハヤシ タケル | Hayashi Takeru
Affiliation and department：
Job title：
Senior Researcher
Homepage URL (1)：
https://www.bikaken.or.jp/
Research field (3)：
Tumor biology
, Structural biochemistry
, Bacteriology
Research keywords (4)：
Gastric cancer
, H. pylori
, CagA
, High throughput screening
Research theme for competitive and other funds (5)：
- 2023 - 2025 PAR1bを標的とした人為的BRCAness誘導によるがん種横断的な合成致死療法開発の研究
- 2021 - 2024 ピロリ菌感染による胃発がん分子機構を標的とした創薬研究
- 2018 - 2021 Structure-function analysis for the induction of pathogenic signaling by H. pylori CagA oncoprotein
- 2016 - 2018 Exploring the small molecule inhibitors that specifically block the intracellular signal perturbation induced by Helicobacter pylori CagA oncoprotein
- 2014 - 2016 Structural and functional analysis of the mechanism underlying perturbation of Csk by Helicobacter pylori virulence factor CagA
Papers (17)：
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Junya Arai, Yoku Hayakawa, Hiroaki Tateno, Keita Murakami, Takeru Hayashi, Masahiro Hata, Yuki Matsushita, Hiroto Kinoshita, Sohei Abe, Ken Kurokawa, et al. Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target. Gastroenterology. 2024
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Takeru Hayashi, Masanori Hatakeyama. Exploring Allosteric Inhibitors of Protein Tyrosine Phosphatases Through High-Throughput Screening. Methods in Molecular Biology. 2023. 2691. 235-245
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Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama. Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization. International Journal of Molecular Sciences. 2022. 23. 12. 6634-6634
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Chi Ben, Xiaojing Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Takeru Hayashi, Masanori Hatakeyama. Alternative splicing reverses the cell-intrinsic and cell-extrinsic prooncogenic potentials of YAP1. The Journal of biological chemistry. 2020
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Hashi K, Imai C, Yahara K, Tahmina K, Hayashi T, Azuma T, Miyabe-Nishiwaki T, Sato H, Matsuoka M, Niimi S, et al. Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate. Scientific reports. 2018. 8. 1. 15981-15981
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MISC (10)：
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Takeru HAYASHI. Recent findings for carcinogenesis by H. pylori infection. Medical Practice. 2021. 38. 6. 915-917
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Takeru hayashi. ピロリ菌の遺伝子多型と胃がん発症リスクを結びつける分子構造解析. PEPTIDE NEWSLETTER JAPAN. 2019. 112. 5-9
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Takeru Hayashi, Miki Senda, Nobuhiro Suzuki, Toshiya Senda, Masanori Hatakeyama. Structural basis for distinct oncogenic activities of Helicobacter pylori CagA variannts. PF Highlights 2017. 2018. 52-53
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千田美紀, 林剛瑠, 長瀬理沙, 長瀬理沙, 畠山昌則, 千田俊哉. ピロリ菌CagAのEPIYAセグメントとSHP2-SH2との複合体の結晶構造に基づいた胃発がん機構解明. KEK Progress Report (Web). 2017. 2016-8. ROMBUNNO.397 (WEB ONLY)
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亀岡章一郎, 亀山武志, 佐藤精一, 林剛瑠, 大西なおみ, 紙谷尚子, 東秀明, 畠山昌則, 高岡晃教. ピロリ菌の病原因子CagAはNLRP3inflammasomeを活性化し,IL-1βを産生する. 日本生化学会大会(Web). 2015. 88th. 3TTOKUP-07(3P1168) (WEB ONLY)
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Lectures and oral presentations (17)：
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Structure-function analysis for deregulation of SHP2 by geographically distinct variants of Helicobacter pylori CagA
(The 37th Sapporo International Cancer Symposium 2018)
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ピロリ菌CagAによる細胞内シグナル撹乱の構造生物学的解析
(マックスプランク・東京大学統合炎症学センター ジュニアフェローセミナー 2017)
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Structural and functional mechanisms underlying activation of SHP2 by geographically distinct Helicobacter pylori CagA oncoproteins
(Europhosphatase 2017: Phosphatases in cell fates and decisions 2017)
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Structural insights into the mechanism underlying activation of SHP2 by the Helicobacter pylori CagA oncoprotein
(The 75th Annual Meeting of the Japanese Cancer Association 2016)
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Biochemical and biophysical analysis for the interaction of Helicobacter pylori CagA oncoprotein with Csk
(The 73rd Annual Meeting of the Japanese Cancer Association 2014)
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Education (2)：
- 2006 - 2012 Hokkaido University Graduate School of Science Division of Chemistry
- 2002 - 2006 Hokkaido University Faculty of Science Division of Chemistry
Professional career (1)：
Work history (3)：
- 2022/04 - 現在 Microbial Chemistry Research Foundation Institute of Microbial Chemistry Senior Researcher
- 2014/04 - 2022/03 The University of Tokyo Graduate School of Medicine Research Associate
- 2013/01 - 2014/03 The University of Tokyo Graduate School of Medicine Project Research Associate (JST-CREST)
Committee career (1)：
- 2021/09 - 現在 Editorial board of Frontiers in Oncology (Molecular and Cellular Oncology) Review Editor
Awards (1)：
- 2013 - 一般財団法人東京医学会 医学研究助成
Association Membership(s) (2)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE CANCER ASSOCIATION
