Rchr
J-GLOBAL ID:201801015979112250   Update date: Feb. 01, 2024

Shin Kobayashi

Shin Kobayashi
Affiliation and department:
Homepage URL  (1): http://staff.aist.go.jp/kobayashi.shin/
Research field  (3): Genetics ,  Developmental biology ,  Laboratory animal science
Research keywords  (10): 実験動物学 ,  クロマチン ,  ライブイメージング ,  pluripotent stem cell ,  genomic imprinting ,  X chromosome inactivation ,  long non-coding RNA ,  human genetic diseases ,  development ,  epigenetics
Research theme for competitive and other funds  (10):
  • 2022 - 2025 新規幹細胞の探索にX染色体再活性がマーカーとなりうることを示す。
  • 2021 - 2023 X染色体不活性化をモデルとしたヘテロクロマチン化維持機構の解明
  • 2020 - 2023 表現型がメンデル遺伝則に従わないヒト疾患のエピジェネティクス研究
  • 2019 - 2021 長鎖ノンコ-ディングRNAが制御する個体発生とヘテロクロマチン形成メカニズム
  • 2018 - 2020 性ホルモン依存しない性差を示す疾患モデルマウスの解析
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Papers (23):
  • Shin Kobayashi. Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain. Nucleic acids research. 2022
  • Shiho Aizawa, Ken Nishimura, Gonzalo Seminario Mondejar, Arun Kumar, Phuong Linh Bui, Yen Thi Hai Tran, Akihiro Kuno, Masafumi Muratani, Shin Kobayashi, Tsukasa Nabekura, et al. Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming. Stem cell reports. 2022. 17. 1. 53-67
  • Mengzhu Zhang, Tohru Kiyono, Kazunori Aoki, Naoki Goshima, Shin Kobayashi, Kengo Hiranuma, Kouya Shiraishi, Hideyuki Saya, Tomomi Nakahara. Development of an in vitro carcinogenesis model of human papillomavirus-induced cervical adenocarcinoma. CANCER SCIENCE. 2021
  • Yoshikazu Haramoto, Mino Sakata, Shin Kobayashi. Visualization of X chromosome reactivation in mouse primordial germ cells in vivo. Biology open. 2021. 10. 4
  • Hosoi Yusuke, Soma Miki, Shiura Hirosuke, Sado Takashi, Hasuwa Hidetoshi, Abe Kuniya, Kohda Takashi, Ishino Fumitoshi, Kobayashi Shin. Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmialike phenotype. NATURE COMMUNICATIONS. 2018. 9
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MISC (20):
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Education (3):
  • 1996 - 1999 東京工業大学大学院博士課程 生命理工学研究科 バイオサイエンス専攻
  • 1994 - 1996 東京工業大学大学院修士課程 生命理工学研究科 バイオサイエンス専攻
  • 1990 - 1994 Tokyo Institute of Technology School of Bioscience and Biotechnology
Work history (7):
  • 2018 - 現在 Toho University Faculty of Science Department of Biology
  • 2017 - 現在 National Institute of Advanced Industrial Science and Technology Molecular Profiling Research Center for Drug Discovery Senior Researcher
  • 2011 - 2021/03 Tokyo Medical and Dental University Medical Research Institute
  • 2011 - 2015 さきがけ研究員兼任
  • 2008 - 2011 Tokyo Medical and Dental University Medical Research Institute
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