Yamaguchi Tomoyuki

YAMAGUCHI TOMOYUKI | Yamaguchi Tomoyuki

Affiliation and department：
Job title： Principle investigator
Homepage URL (1)： https://researchmap.jp/blogs/blog_entries/view/120670/c1ab95d972fe95d72e7ddfdf9cbf8dce?frame_id=784364

Research field (2)： Biophysics , Immunology

Research theme for competitive and other funds (2)：

2015 - 2018 Theoretical and experimental analyses to reveal the mechanisms of immune regulation
2008 - 2012 Molecular basis of the function and generation of Foxp3-expressing regulatory T cells

Papers (47)：

Tomoyuki Yamaguchi. Reinforcement learning in biological systems for adaptive regulation. 2023
Tomoyuki Yamaguchi. Learning processes in hierarchical pairs regulate entire gene expression in cells. Scientific Reports. 2022. 12. 1
Tomoyuki Yamaguchi, Toshie Shinagawa, Hisanobu Kobata, Hidemitsu Nakagawa. Immunity against seasonal human coronavirus OC43 mitigates fatal deterioration of COVID-19. International Journal of Infectious Diseases. 2021. 109. 261-268
Hiroaki Machiyama, Tomoyuki Yamaguchi, Tomonobu M Watanabe, Toshio Yanagida, Hideaki Fujita. Activation probability of a single naïve T cell upon TCR ligation is controlled by T cells interacting with the same antigen-presenting cell. FEBS letters. 2021. 595. 1512-1524
Tomoyuki Yamaguchi, Shunsuke Teraguchi, Chikara Furusawa, Hiroaki Machiyama, Tomonobu M, Watanabe, Hideaki Fujita, Shimon Sakaguchi, Toshio Yanagida. Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance. International Immunology. 2019. 31. 11. 743-753

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MISC (7)：

Immune regulation mediated by regulatory T cells. Cell technology. 2011. 30. 7. 748-753
SATO MASAFUMI, YASUNAGA JUN'ICHIRO, YOSHIDA MIKA, MIYASATO PAORA, CHO TETSUGUN, TAKAI KEN, SHIMIZU KATSURA, OSHIMA KOICHI, YAMAGUCHI TOMOYUKI, ONO MASAHIRO, et al. HTLV-1 bZIP Factor(HBZ)遺伝子トランスジェニックマウスは慢性炎症疾患,T細胞リンパ腫を発症する. 臨床血液. 2009. 50. 9. 1012-1012
Immunosuppression mediated by CTLA-4 expressed on regulatory T cells. Clinical immunology & allergology. 2009. 51. 4. 428-434
中村恭子, 廣田圭司, Fehervari Zoltan, 山口智之, 野村尚史, 坂口志文. CD25+CD4+制御性T細胞におけるFoxP3,CTLA-4の役割. 日本免疫学会総会・学術集会記録. 2004. 34. 137-137
熊野恵城, 千葉滋, 國里篤志, 山口悦子, 齋藤俊樹, 山口智之, 増田茂夫, 平井久丸. Notch1及びNotch2の造血発生における役割. 炎症・再生. 2003. 23. 6. 467-467

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Lectures and oral presentations (7)：

制御性T細胞による免疫調節機構の数理モデルとシミュレーション
(第2回理論免疫学ワークショップ 2018)
免疫応答の理論モデルが示す制御性T細胞の免疫調節機構
(第4回病因研究会別府シンポジウム 2018)
A simulation model of immune response predicts essential functions of Treg to maintain immune tolerance.
(第46回日本免疫学会学術集会 2017)
Control of immune response based on a theoretical model of T cell proliferation
(第45回日本免疫学会学術集会 2016)
Modeling for T cell-mediated immune regulation
(日本免疫学会総会)

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Education (3)：

Work history (3)：

2017 - 現在 Research Institute, Nozaki Tokushukai Hospital Basic Immunology Principal Investigator
2011 - 2017 Osaka University WPI Immunology Frontier Research Center
2003 - 2011 Kyoto University Institute for Frontier Medical Sciences Field of Biological Function Department of Experimental Pathology

Association Membership(s) (3)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR IMMUNOLOGY , 日本生物物理学会

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