Rchr
J-GLOBAL ID：201801016052687197
Update date: Jan. 22, 2025
SASAKI HIROSHI
ササキ ヒロシ | SASAKI HIROSHI
Affiliation and department：
Job title：
Professor
Research field (1)：
Developmental biology
Research keywords (5)：
intercellular communications
, cell competition
, Hippo signaling
, mouse
, early embryogenesis
Research theme for competitive and other funds (32)：
- 2021 - 2026 Elucidation of the molecular basis and dynamics of cell competition that supports autonomy of mouse embryonic multicellular systems.
- 2021 - 2026 Understanding multicellular autonomy by competitive cell-cell communications
- 2020 - 2023 Mechanisms and roles of the quality control of epiblast during its formation in mouse embryos
- 2019 - 2021 Development of the method for rapid production of embryo specific mutant mouse.
- 2019 - 2021 細胞と場の連携による着床前マウス胚の2段階細胞分化機構
- 2017 - 2020 Intercellular communications in embryos that recognizes Hippo signaling of the neighboring cells
- 2017 - 2019 Various mechanisms of cell competition in mouse embryos
- 2015 - 2017 線維芽細胞における細胞競合機構とその発生学的意義
- 2014 - 2016 上皮組織の細胞動態制御機構の解析
- 2013 - 2016 Clarification of the reciprocal interactions between Amot and Lats in activation of the Hippo pathway
- 2011 - 2016 Molecular basis of intercellular communication by Hippo pathway
- 2009 - 2014 Regulation of cellular community of mouse embryos by cell-cell contacts
- 2009 - 2014 Cell Community in early mammalian development
- 2002 - 2004 Studies on the establishment of the primitive streak region
- 2001 - 2004 哺乳動物前後軸形成の分子機構
- 2002 - 2003 TEFとVestigialに注目した脊椎動物の体軸形成機構の解析
- 2001 - 2002 頭部誘導に関わる遺伝子群の単離と機能解析
- 2001 - 2001 形制御の遺伝子プログラムの解析
- 1999 - 2001 形態の多様性を生み出す分子機構の解析
- 1999 - 2001 Regulation of Cell Differentiation by Sox Family Transcription Fctors
- 2000 - 2000 転写因子Gli2による神経管腹側パターン形成機構の解析
- 2000 - 2000 転写因子の機能に注目した脊椎動物のオーガナイザー・脊索形成機構の解析
- 1999 - 2000 マウス胚のオーガナイザー・脊索形成に関与する新規転写因子の単離と機能解析
- 1999 - 1999 転写因子の機能に注目した脊椎動物のオーガナイザー・脊索形成機構の解析
- 1999 - 1999 転写因子Gli2による神経管腹側パターン形成機構の解析
- 1998 - 1998 転写因子の機能に注目した脊椎動物のオーガナイザー・脊索形成機構の解析
- 1998 - 1998 神経管腹側パターン形成機構の解析
- 1997 - 1998 Mechanism of HNF3beta induction by a dorsal mesoderm inducer Smad2
- 1997 - 1997 転写因子の機能に注目した脊椎動物のオ-ガナイザー・脊索形成機構の解析
- 1997 - 1997 神経管腹側パターン形成機構の解析
- 1996 - 1996 転写因子HNF3βのノード・脊索特異的遺伝子発現の制御機構の解析
- 1991 - 1991 オンコジ-ンタンパク質との融合化によるホメオドメインタンパク質の標的遺伝子の探索
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Papers (66)：
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Weixia Kong, Masatoshi Hara, Yurika Tokunaga, Kazuhiro Okumura, Yasuhiro Hirano, Jiahang Miao, Yusuke Takenoshita, Masakazu Hashimoto, Hiroshi Sasaki, Toshihiko Fujimori, et al. CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation. Life Science Alliance. 2024. 8. 1. e202402927-e202402927
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Hidekazu Ishida, Rie Saba, Ioannis Kokkinopoulos, Masakazu Hashimoto, Osamu Yamaguchi, Sonja Nowotschin, Manabu Shiraishi, Prashant Ruchaya, Duncan Miller, Stephen Harmer, et al. GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell reports. 2023. 42. 11. 113383-113383
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Tomoaki Otsuka, Hiromi Shimojo, Hiroshi Sasaki. Daughter cells inherit YAP localization from mother cells in early preimplantation embryos. Development, growth & differentiation. 2023
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Hiroshi Koyama, Makoto Suzuki, Naoko Yasue, Hiroshi Sasaki, Naoto Ueno, Toshihiko Fujimori. Differential cellular stiffness contributes to tissue elongation on an expanding surface. Frontiers in cell and developmental biology. 2022. 10. 864135-864135
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Masakazu Hashimoto, Hiroshi Sasaki. Cell competition controls differentiation in mouse embryos and stem cells. Current opinion in cell biology. 2020. 67. 1-8
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MISC (1)：
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