Matsubara Tsutomu

マツバラツトム | Matsubara Tsutomu

Affiliation and department：

Research field (3)： Metabolism and endocrinology , Pathobiochemistry , Anatomy

Research theme for competitive and other funds (14)：

2024 - 2027 Unmet Medical Needsである低アルブミン血症に対する改善候補化合物の分子機序解明
2022 - 2025 Functions of the cholangiocarcinoma suppressor gene extracted from printing company workers' samples: From cell cycle regulation to drug discovery
2021 - 2025 HSD17B4の新機能に着目した肝硬変治療薬の開発
2020 - 2024 In-vivo sub-cellular thermometry for quantitative thermal biology
2021 - 2024 Elucidation of irreversible switch mechanism in hepatic stellate cell activation

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Papers (62)：

Hung Thai Vu, Vien Duc Nguyen, Hiroko Ikenaga, Tsutomu Matsubara. Application of PPAR Ligands and Nanoparticle Technology in Metabolic Steatohepatitis Treatment. Biomedicines. 2024. 12. 8
Etsushi Kawamura, Tsutomu Matsubara, Norifumi Kawada. New Era of Immune-Based Therapy in Intrahepatic Cholangiocarcinoma. Cancers. 2023. 15. 15
Hayato Urushima, Tsutomu Matsubara, Masaaki Miyakoshi, Shioko Kimura, Hideto Yuasa, Katsutoshi Yoshizato, Kazuo Ikeda. Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway. American journal of physiology. Gastrointestinal and liver physiology. 2023. 324. 3. G219-G230
Etsushi Kawamura, Tsutomu Matsubara, Atsuko Daikoku, Sanae Deguchi, Masahiko Kinoshita, Hideto Yuasa, Hayato Urushima, Naoshi Odagiri, Hiroyuki Motoyama, Kohei Kotani, et al. Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21. FEBS Open Bio. 2022. 12. 12. 2122-2135
Truong Huu Hoang, Misako Sato-Matsubara, Hideto Yuasa, Tsutomu Matsubara, Le Thi Thanh Thuy, Hiroko Ikenaga, Dong Minh Phuong, Ngo Vinh Hanh, Vu Ngoc Hieu, Dinh Viet Hoang, et al. Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. Science Advances. 2022. 8. 39

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MISC (25)：

小田桐直志, 松原勤, 河田則文. 肝疾患と微小環境加齢関連肝疾患における肝星細胞の理解. 肝臓. 2020. 61. Suppl.1. A50-A50
川村悦史, 松原勤, 樋口萌, 出口早苗, 高田さゆり, 大黒敦子, 伊藤得路, 木下正彦, 松原三佐子, 小田桐直志, et al. 若年胆管癌組織を使った癌抑制遺伝子の探索. 肝臓. 2019. 60. Suppl.3. A926-A926
松原三佐子, 松原三佐子, 谷口絵美, 谷口絵美, 松原勤, 宇留島隼人, 大黒敦子, 森浦芳枝, 門野千穂, 門野千穂, et al. 直接的細胞接着に依存する肝細胞と星細胞の緊密な相互作用. 肝細胞研究会プログラム・抄録集. 2019. 26th
大黒敦子, 松原勤, 松原三佐子, 松原三佐子, 池田一雄, 河田則文. LawsoneはヒトCYGB遺伝子発現誘導作用を持つ抗線維化化合物である. 肝細胞研究会プログラム・抄録集. 2019. 26th
松原勤, 高田さゆり, 高田さゆり, 松原三佐子, 松原三佐子, 大黒敦子, 小田桐直志, 宇留島隼人, 吉里勝利, 河田則文, et al. 老化肝星細胞におけるTGFβシグナル変化の分子機序解析. 肝細胞研究会プログラム・抄録集. 2019. 26th

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Patents (4)：

Professional career (1)：

Work history (2)：

2022/04 - 現在 Osaka Metropolitan University School of Medicine Department of Medical Science Associate Professor
2016/07 - 現在 Osaka City University Graduate School of Medicine Basic Medicine Course Associate Professor

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