Rchr
J-GLOBAL ID：201801016411743421
Update date: Feb. 26, 2024
Tomoko Toramaru
トラマル トモコ | Tomoko Toramaru
Affiliation and department：
Job title：
Instructor
Research field (1)：
Anesthesiology
Research keywords (1)：
Anesthesiology Hypoxia
Research theme for competitive and other funds (2)：
- 2022 - 2025 マウス術後複合性局所疼痛症候群モデルにおける中枢性感作の可視化と治療標的の探索
- 2019 - 2022 低酸素応答を介した病的疼痛の重症化・慢性化の機序の解明
Papers (5)：
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Jungo Kato, Reiko Murase, Rie Minoshima, Fanglin Lu, Tomoko Toramaru, Yasuo Niki, Shizuko Kosugi, Hiroshi Morisaki. Levels of preoperative cerebrospinal fluid pro-inflammatory mediators and chronic pain after total knee arthroplasty surgery. Acta Anaesthesiologica Scandinavica. 2023. 67. 8. 1091-1101
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Fanglin Lu, Jungo Kato, Tomoko Toramaru, Mengting Zhang, Hiroshi Morisaki. Pharmacological Ischemic Conditioning with Roxadustat Does Not Affect Pain-Like Behaviors but Mitigates Sudomotor Impairment in a Murine Model of Deep Hind Paw Incision. Journal of Pain Research. 2023. Volume 16. 573-587
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Fanglin Lu, Jungo Kato, Tomoko Toramaru, Megumi Sugai, Mengting Zhang, Hiroshi Morisaki. Objective and Quantitative Evaluation of Spontaneous Pain-Like Behaviors Using Dynamic Weight-Bearing System in Mouse Models of Postsurgical Pain. Journal of Pain Research. 2022. Volume 15. 1601-1612
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Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Akiko Kubo, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, et al. Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment. MOLECULAR AND CELLULAR BIOLOGY. 2017. 37. 16. e00248-17
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Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin, Makoto Suematsu, et al. Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015. 112. 37. 11642-11647
MISC (2)：
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壽原 朋宏, 伊原 奈帆, 南嶋 しづか, 寅丸 智子, 鈴木 悠太, 長田 大雅, 山田 高成, 南嶋 洋司, 森崎 浩. 敗血症に関する基礎研究-2 低酸素応答は敗血症の予後を改善させるか?. 日本集中治療医学会雑誌. 2020. 27. Suppl. 280-280
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寅丸智子. その低血圧, そのままで大丈夫? ~術中低血圧が引き起こす病態たち~. 臨床麻酔. 2020
Patents (1)：
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Drug for preventing or treating lactic acidosis
Lectures and oral presentations (5)：
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プロリン水酸化酵素阻害による低酸素応答活性化はマウス術後痛モデルでの創部自律神経障害を改善する.
(第69回日本麻酔科学会学術集会 2022)
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プロリン水酸化酵素阻害はマウス手術後痛モデル創部で神経障害を惹起する
(第68回日本麻酔科学会学術集会 2021)
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マウスモデルによる虚血肢痛における低酸素応答関連分子の関与の検討
(第67回日本麻酔科学会学術集会 2020)
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Targeting oxygen sensing prolyl hydroxylase (PHD) for metformin-associated lactic acidosis (MALA) treatment
(Japanese Society of Anesthesiologists 2017)
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Prolyl hydroxylase (PHD) as a therapeutic target for metformin-associated lactic acidosis
(The Japanese Association for Hypoxia Biology 2016)
Professional career (1)：
Awards (2)：
- 2022/06 - 第69回日本麻酔科学会学術集会 優秀演題賞 プロリン水酸化酵素阻害による低酸素応答活性化はマウス術後痛モデルでの創部自律神経障害を改善する.
- 2016/07 - The Japanese Association for Hypoxia Biology Young investigator award Prolyl hydroxylase (PHD) as a therapeutic target for metformin-associated lactic acidosis
Association Membership(s) (1)：
Japanese Society of Anesthesiologists
