Morihara Hirofumi

Affiliation and department：
Homepage URL (1)： https://www.ompu.ac.jp/u-deps/pha/pdf/morihara-1.pdf

Research field (2)： Pathobiochemistry , Pharmacology

Research keywords (6)：腫瘍循環器 , ハイスループットスクリーニング , 創薬 , 遺伝性疾患 , 病態モデル , iPS細胞

Research theme for competitive and other funds (8)：

2024 - 2027 第3世代 EGFR チロシンキナーゼ阻害薬による心毒性と V-ATPase の関係性について
2022 - 2025 Establishment and mechanistic analysis of a model of cardiac dysfunction caused by molecular-targeted cancer drugs
2022 - 2025 The cell-based vascular model with the inducible pluripotent stem cells of Marfan syndrome.
2023 - 2024 心不全時の心骨格筋連関における TMEM182 の病態的役割の解明
2022 - 2023 筋肉特異的に発現する機能未知膜蛋白質 TMEM182 の生理学的・病態学的役割の解明

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Papers (11)：

Hirofumi Morihara, Shunichi Yokoe, Shigeo Wakabayashi, Shinji Takai. TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β-catenin signaling through an increase in ILK expression. FASEB BioAdvances. 2024. 6. 11. 565-579
Natsuko Morita, Hirofumi Morihara, Kazumasa Moriwaki, Atsushi Daimon, Michio Asahi, Masahide Ohmichi. Intravenous Injection of iPS Cell-Derived Endothelial Progenitor Cells Prevents Miscarriage by Releasing Pro-Angiogenic Factors in a Mouse Model of Recurrent Spontaneous Abortion. Bulletin of Osaka Medical and Pharmaceutical University. 2023. 69. 1-2. 21-30
Mahito Matsuno, Shunichi Yokoe, Takehiro Nagatsuka, Hirofumi Morihara, Kazumasa Moriwaki, Michio Asahi. O-GlcNAcylation-induced GSK-3β activation deteriorates pressure overload-induced heart failure via lack of compensatory cardiac hypertrophy in mice. Frontiers in Endocrinology. 2023. 14
Mime Kobayashi, Kiichiro Tomoda, Hirofumi Morihara, Michio Asahi, Tetsuji Shimizu, Shinya Kumagai. Non-thermal atmospheric-pressure plasma potentiates mesodermal differentiation of human induced pluripotent stem cells. Heliyon. 2022. 8. 12. e12009-e12009
Atsushi Daimon, Hirofumi Morihara, Kiichiro Tomoda, Natsuko Morita, Yoshinori Koishi, Kazuyoshi Kanki, Masahide Ohmichi, Michio Asahi. Intravenously Injected Pluripotent Stem Cell-derived Cells Form Fetomaternal Vasculature and Prevent Miscarriage in Mouse. Cell Transplantation. 2020. 29. 096368972097045-096368972097045

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Patents (1)：

Lectures and oral presentations (11)：

ヒトiPS細胞由来心筋細胞を用いた研究
(第3回あべの薬理学懇話会 2024)
TMEM182 は integrin-linked kinase を増加させることで Wnt/β-catenin シグナルの活性化状態を維持しヒトiPS細胞の心筋分化を抑制する
(第33回日本循環薬理学会 2024)
TMEM182 maintains the activated state of Wnt/β-catenin signaling by increasing ILK and inhibits cardiac differentiation in human iPS cells
(The 96th Annual Meeting of the Japanese Pharmacological Society 2022)
Effect of TMEM182, a novel membrane protein, on muscle differentiation
(The 95th Annual Meeting of the Japanese Pharmacological Society 2022)
Lysosomal Regulation of mTOR-AKT Signaling via the Vacuolar-type H+- ATPase
(The 93rd Annual Meeting of the Japanese Pharmacological Society 2020)

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Education (2)：

Professional career (1)：

Work history (2)：

Association Membership(s) (3)：

日本循環薬理学会 , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY

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