HIDEAKI FUJII

• Takashi Iwai, Rei Mishima, Shigeto Hirayama, Honoka Nakajima, Misa Oyama, Shun Watanabe, Hideaki Fujii, Mitsuo Tanabe. SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis. Journal of Clinical Medicine. 2024. 13. 2. 608-608
• Fumika Karaki, Taro Takamori, Koumei Kawakami, Sae Sakurai, Kyoko Hidaka, Kei Ishii, Tomoya Oki, Noriko Sato, Nao Atsumi, Karin Ashizawa, et al. Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol. Molecules. 2023. 28. 19. 6925-6925
• Yuki Moriya, Yoshiyuki Kasahara, Masafumi Shimada, Yasufumi Sakakibara, Hideaki Fujii, Hiroshi Nagase, Soichiro Ide, Kazutaka Ikeda, F. Scott Hall, George R. Uhl, et al. Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127. Journal of Pharmacological Sciences. 2023. 151. 3. 135-141
• Takaaki Mizuguchi, Kanako Miyano, Risa Yamauchi, Yuki Yoshida, Hideki Takahashi, Ami Yamazaki, Haruka Ono, Miku Inagaki, Miki Nonaka, Yasuhito Uezono, et al. The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the μ opioid receptor. Peptides. 2023. 159. 170901-170901
• Kennosuke Itoh, Nanase Ishii, Atsushi Takashino, Aya Hara, Satoshi Kon, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Yoshio Shibagaki, Kenichiro Nagai, et al. Visible-light-Induced synthesis of imidazolidines through formal [3 + 2] cycloaddition of aromatic imines with N,N,N',N'-tetramethyldiaminomethane. Journal of Photochemistry and Photobiology A: Chemistry. 2023. 434. 114239-114239

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• Hideaki Fujii. New Advances in the Medicinal Chemistry of Opioid Receptor Ligands. Current Topics in Medicinal Chemistry. 2020. 20. 31. 2821-2821
• Hirokazu Mizoguchi, Hideaki Fujii. Exploring μ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics. Current Topics in Medicinal Chemistry. 2020. 20. 31. 2866-2877
• 山口政広, 山口政広, 山口政広, 宮野加奈子, 根本徹, 原田幸昌, 今出慧海, 野村俊宗, 唐澤佑輔, 唐澤佑輔, et al. Evaluation of activities of nalfurafine derivatives, the κ opioid receptor agonists to develop novel analgesics with fewer side effects. Pain Research. 2020. 35. 4. 247-247
• 唐澤佑輔, 唐澤佑輔, 唐澤佑輔, 宮野加奈子, 山内梨瑳, 水口貴章, 上園瑛子, 上園瑛子, 小松茜, 小松茜, et al. Evaluation of spinach-derived opioid peptide Rubiscolin for the development of novel analgesics with few side effects. Pain Research. 2020. 35. 4. 248-248
• Shigeto Hirayama, Hideaki Fujii. Delta Opioid Receptor Inverse Agonists and Their in vivo Pharmacological Effects. Current Topics in Medicinal Chemistry. 2020. 20. 31. 2889-2902

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• スタンダード薬学シリーズII3 化学系薬学II
  東京化学同人 2016

• 新規 1,2,5-オキサジアジナン誘導体: 光化学的合成, 抗住血吸虫活性, ADMET 特性
  (日本薬学会第144年会 2024)
• μオピオイド受容体に対する新奇バイトピックリガンドを指向したオキシトシンとエンドモルフィン-1から成る二価型化合物の合成研究
  (日本薬学会第144年会 2024)
• ドラッグライブラリー構築における二置換トリアゾール部位の置換様式の変更
  (第85回有機合成化学協会関東支部シンポジウム 2023)
• メチル基以外の置換基を有する5ʹ-置換ピラゾロモルヒナン誘導体の合成検討
  (第85回有機合成化学協会関東支部シンポジウム 2023)
• Synthesis and evaluation of 1,6-disubstituted pyrrolizidine-3-one derivatives to discover a novel agonist for opioid receptors
  (第60回ペプチド討論会 2023)

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• 1991 - 1993 Kyoto University Graduate School, Division of Engineering Industrial Chemistry
• 1987 - 1991 Kyoto University Faculty of Engineering Fepartment of Industrial Chemistry

• 博士(工学) (京都大学)

Japanese Society for Chemical Biology ,  American Chemical Society ,  Japanese Narcotic Research Coference ,  The Chemiacl Society of Japan ,  Japanese Society for Pharmaceutical Palliative Care and Sciences ,  The Pharmaceutical Society of Japan ,  The Society of Organic Synthetic Chemistry, Japan