HIDEAKI FUJII

• Ayaka Watanabe, Shuma Yamada, Haruka Yoshida, Miku Inagaki, Nao Atsumi, Aoba Matsushima, Naoki Takahashi, Naoto Ishibashi, Takumi Ogino, Ryoto Someya, et al. Structure-Activity Relationship Study of CYM51010, an Agonist for the μ-δ Opioid Receptor Heterodimer. Chemical and Pharmaceutical Bulletin. 2024. 72. 7. 711-730
• Kanako Miyano, Miki Nonaka, Masahiro Sakamoto, Mika Murofushi, Yuki Yoshida, Kyoko Komura, Katsuya Ohbuchi, Yoshikazu Higami, Hideaki Fujii, Yasuhito Uezono. The Inhibition of TREK-1 K+ Channels via Multiple Compounds Contained in the Six Kamikihito Components, Potentially Stimulating Oxytocin Neuron Pathways. International Journal of Molecular Sciences. 2024. 25. 9. 4907-4907
• Takashi Iwai, Rei Mishima, Shigeto Hirayama, Honoka Nakajima, Misa Oyama, Shun Watanabe, Hideaki Fujii, Mitsuo Tanabe. SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis. Journal of Clinical Medicine. 2024. 13. 2. 608-608
• Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, et al. Anti-Schistosomal Activity and ADMET Properties of 1,2,5-Oxadiazinane-Containing Compound Synthesized by Visible-Light Photoredox Catalysis. RSC Medicinal Chemistry. 2024
• Fumika Karaki, Taro Takamori, Koumei Kawakami, Sae Sakurai, Kyoko Hidaka, Kei Ishii, Tomoya Oki, Noriko Sato, Nao Atsumi, Karin Ashizawa, et al. Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol. Molecules. 2023. 28. 19. 6925-6925

ｍore...

• Fumika Karaki, Hideaki Fujii. Recent progress in the construction of sp3-rich compound libraries with natural product-like properties. Studies in Natural Products Chemistry. 2024. 81. 1-37
• Hideaki Fujii. New Advances in the Medicinal Chemistry of Opioid Receptor Ligands. Current Topics in Medicinal Chemistry. 2020. 20. 31. 2821-2821
• Hirokazu Mizoguchi, Hideaki Fujii. Exploring μ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics. Current Topics in Medicinal Chemistry. 2020. 20. 31. 2866-2877
• 山口政広, 山口政広, 山口政広, 宮野加奈子, 根本徹, 原田幸昌, 今出慧海, 野村俊宗, 唐澤佑輔, 唐澤佑輔, et al. Evaluation of activities of nalfurafine derivatives, the κ opioid receptor agonists to develop novel analgesics with fewer side effects. Pain Research. 2020. 35. 4. 247-247
• 唐澤佑輔, 唐澤佑輔, 唐澤佑輔, 宮野加奈子, 山内梨瑳, 水口貴章, 上園瑛子, 上園瑛子, 小松茜, 小松茜, et al. Evaluation of spinach-derived opioid peptide Rubiscolin for the development of novel analgesics with few side effects. Pain Research. 2020. 35. 4. 248-248

ｍore...

• スタンダード薬学シリーズII3 化学系薬学II
  東京化学同人 2016

• 半夏瀉心湯は炎症性メディエーター Cyclooxygenase-2、 Interleukin-1β、Interleukin-6の産生を抑制し口腔粘膜炎を改善する
  (第150回日本薬理学会関東部会 2024)
• モルヒネ非感受性μオピオイド受容体スプライスバリアント選択的作動薬を志向したモルヒナン誘導体の評価
  (第150回日本薬理学会関東部会 2024)
• より高選択的かつ高活性なμ/δヘテロダイマー作動薬の創出を目指した新規オピオイド化合物の合成ならびに活性評価
  (第150回日本薬理学会関東部会 2024)
• GloSensor cAMPアッセイシステムを用いた新規化合物の評価~δオピオイド受容体選択的リガンドを志向した化合物の創出を目指して~
  (第150回日本薬理学会関東部会 2024)
• 新規μ/δ二量体化オピオイド受容体作動薬SYK-663の各オピオイド受容体およびマウス鎮痛効果に及ぼす影響
  (第150回日本薬理学会関東部会 2024)

ｍore...

• 1991 - 1993 Kyoto University Graduate School, Division of Engineering Industrial Chemistry
• 1987 - 1991 Kyoto University Faculty of Engineering Fepartment of Industrial Chemistry

• 博士(工学) (京都大学)

Japanese Society for Chemical Biology ,  American Chemical Society ,  Japanese Narcotic Research Coference ,  The Chemiacl Society of Japan ,  Japanese Society for Pharmaceutical Palliative Care and Sciences ,  The Pharmaceutical Society of Japan ,  The Society of Organic Synthetic Chemistry, Japan