Rchr
J-GLOBAL ID:201801016523135645
Update date: Sep. 17, 2024
Akagi Reiko
アカギ レイコ | Akagi Reiko
Affiliation and department:
Job title:
Professor
Research field (3):
Molecular biology
, Functional biochemistry
, Pathobiochemistry
Research keywords (5):
intestinal barrier function
, heme oxygenase
, heat shock protein
, heme
, oxidative stress
Research theme for competitive and other funds (22):
- 2024 - 2027 Inhibitors of kynurenine production: drug development of non-conventional IDO1 inhibitor A and elucidation of mechanism of action by cpd B.
- 2019 - 2022 Mechanism of intestinal barrier disruption caused by free heme causing aggravation of sepsis
- 2011 - 2013 Regulation of heme oxygenase 1 gene expression by heat shock factor1
- 2010 - 2012 Studies on the molecular mechanism of protective effect of glutamine on intestinal barrier dysfunction
- 2003 - 2005 Effects of heme metabolism on the proliferation or differentiation of various cells in the regeneration liver
- 2003 - 2004 Toll-like receptorの遺伝子多型が敗血症の病態と予後に及ぼす影響
- 2003 - 2004 An anti-inflammatory cytokine, Interleukin-11 : A therapeutic target against septic MODS
- 2000 - 2001 抗炎症性サイトカインとストレス蛋白が敗血症の予後に及ぼす影響
- 1999 - 2001 Molecular mechanism of inhaled anesthetic-induced hepatotoxicity
- 1998 - 2000 The role of heat shock proteins in ischemic acute renal failure
- 1997 - 1998 The role of heat shock proteins in inhaled anesthetics-induced organ toxicity
- 1995 - 1997 Molecular Mechanism of Erythroid Differentiation
- 1995 - 1995 環境因子に対する遺伝的ハイリスクグループの分子生物学的予知のこころみ
- 1994 - 1995 ヘム合成酵素におけるスプライシング異常と赤血球分化との関係
- 1994 - 1994 環境因子に対する遺伝的ハイリスクグループの分子生物学的予知のこころみ
- 1994 - 臓器障害におけるヘム代謝の動態
- 1994 - Heme Metabolism Organ Failures
- 1994 - Physiological Roles of Heme Metabolism in Placenta
- 1994 - 胎盤におけるヘム代謝の生理学的意義
- 1990 - 1993 Studies on thrombolytic enzyme nattokinase
- 1991 - Molecular Analysis of Defective Enzymes in Porphyria.
- 1991 - ポルフィリン症における異常遺伝子の分子生物学的解析
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Papers (114):
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Daisuke Tsuji, Tasuku Hirayama, Kanta Kawai, Hideko Nagasawa, Reiko Akagi. Application of fluorescent probe for labile heme quantification in physiological dynamics. Biochimica et Biophysica Acta (BBA) - General Subjects. 2024. 1868. 11. 130707-130707
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Rena Takizawa, Yusei Shimomoto, Daisuke Tsuji, Kiyoshi Imabayashi, Kohji Itoh, Reiko Akagi, Yoshiki Kashiwada, Naonobu Tanaka. Formohyperins G-L, polycyclic prenylated benzoylphloroglucinols from the flowers of Hypericum formosanum. Journal of Natural Medicines. 2024. 78. 4. 970-977
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Naonobu Tanaka, Rena Takizawa, Yusei Shimomoto, Daisuke Tsuji, Koji Yonekura, Kohji Itoh, Reiko Akagi, Yoshiki Kashiwada. Meroterpenes and prenylated benzoylphloroglucinol from the flowers of Hypericum formosanum. Phytochemistry. 2024. 220. 114016-114016
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Yuki Yoshino, Masaki Imanishi, Licht Miyamoto, Daisuke Tsuji, Reiko Akagi, Koichiro Tsuchiya, Yoshiki Kashiwada, Naonobu Tanaka. Dauferulins A-L, daucane-type sesquiterpenes from the roots of Ferula communis: Their structures and biological activities. Fitoterapia. 2024. 174. 105877-105877
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Yuna Kondo, Tenta Nakamura, Daisuke Tsuji, Ryota Sato, Sangita Karanjit, Reiko Akagi, Kosuke Namba. Development of 1,3a,6a-triazapentalene derivatives as practical erasable fluorescent cell staining reagents. Tetrahedron Letters. 2024. 138. 154986-154986
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MISC (82):
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井上幸江, 伊豫田拓也, 沖田直之, 縄田望月, 松本芽衣, 宮本崇史, 辻大輔, 赤木玲子. Induced expression of heme oxygenase-1, an antioxidant enzyme, associated with cell differentiation of myeloid cell line (HL-60). 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
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有馬朋花, 辻大輔, 赤木玲子. Nrf2による細胞内遊離鉄制御を介したフェロトーシスへの影響. 日本鉄バイオサイエンス学会学術集会プログラム・抄録集. 2023. 47th
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辻大輔, 平山祐, 井上幸江, 赤木玲子. 消化管バリア機能におけるヘム鉄の役割. 日本鉄バイオサイエンス学会学術集会プログラム・抄録集. 2023. 47th
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辻 大輔, 赤木 玲子. アセトアミノフェンによる肝細胞死の動物種による差異とそのメカニズム. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1P-201
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赤木玲子, 久保貴紀, 羽鳥勇太, 宮本崇史, 井上幸江. ラットHeme oxygenase-1の熱ショック応答~HSF1,NRF2,BACH1による転写調節~. 日本生化学会大会(Web). 2021. 94th
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Education (4):
- 1978 - 1982 Okayama University
- 1976 - 1978 Okayama University
- 1972 - 1976 Okayama University Medical School
- 1969 - 1972 岡山県立岡山朝日高等学校
Professional career (1):
Work history (7):
- 2008/04 - 現在 Yasuda Women's University Faculty of Pharmacy
- 1997/04 - 2008/03 Okayama Prefectural University Graduate School of Health and Welfare
- 1993/04 - 2008/03 Okayama Prefectural University Health and Welfare Science, Department of Nutritional Science
- 1991/10 - 1999/10 The Rockefeller University Biochemical Hematology Visiting Assistant Professor
- 1983/04 - 1992/03 岡山県立短期大学 食物科 専任講師
- 1983/04 - 1986/03 Okayama University Medical School
- 1982/04 - 1983/03 Okayama University Medical School
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Awards (1):
- 1989 - 財団法人両備樫園記念財団 生物学研究助成
Association Membership(s) (6):
日本臨床ストレス応答学会
, 日本鉄バイオサイエンス学会
, The Molecular Biology Society of Japan
, 日本薬学会
, 日本生化学会
, 日本薬理学会
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