Kuwata Hiroshi

クワタヒロシ | Kuwata Hiroshi

Research field (1)： Pharmaceuticals - health and biochemistry

Research theme for competitive and other funds (16)：

2019 - 2022 The effects of endogenous PUFA restriction on biological functions
2016 - 2019 Exploration of novel factors reducing toxicity of environmental chemicals by utilizing toxicolipidomic analyses
2013 - 2016 Development of a novel analysis and evaluation system for environmental chemicals-induced toxicity using toxicolipidomics
2009 - 2012 Studies on novel mechanisms of environmental chemicals-induced toxicity using arachidonate-metabolizing enzyme genetically modified mice
2010 - 2011 Studies on the bioactive phospholipids that regulate various proinflammatory responses

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Papers (63)：

Tsubasa Ochiai, Toshiya Honsawa, Keishi Yamaguchi, Yuka Sasaki, Chieko Yokoyama, Hiroshi Kuwata, Shuntaro Hara. Prostacyclin synthase deficiency exacerbates systemic inflammatory responses in lipopolysaccharide-induced septic shock in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024
Hiroshi Kuwata, Eriko Nakatani, Yuki Tomitsuka, Tsubasa Ochiai, Yuka Sasaki, Emiko Yoda, Shuntaro Hara. Deficiency of long-chain acyl-CoA synthetase 4 leads to lipopolysaccharide-induced mortality in a mouse model of septic shock. The FASEB Journal. 2023. 37. 12
Yuki Tomitsuka, Hiroki Imaeda, Haruka Ito, Isaki Asou, Masayuki Ohbayashi, Fumihiro Ishikawa, Hiroshi Kuwata, Shuntaro Hara. Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation. Redox biology. 2023. 66. 102850-102850
冨塚祐希, 桑田浩, 原俊太郎. 化学物質曝露に伴う肺傷害における長鎖アシルCoA合成酵素(ACSL)4の機能解析. 脂質生化学研究. 2023. 65. 82-83
冨塚祐希, 桑田浩, 原俊太郎. パラコートの肺毒性発現における長鎖アシルCoA合成酵素(ACSL)4の役割の解析. The Journal of Toxicological Sciences. 2022. 47. Suppl. S136-S136

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MISC (56)：

冨塚祐希, 桑田浩, 原俊太郎. 化学物質曝露に伴う肺傷害における長鎖アシルCoA合成酵素(ACSL)4の機能解析. 脂質生化学研究. 2023. 65
冨塚祐希, 桑田浩, 原俊太郎. 長鎖アシルCoA合成酵素4の欠損は化学物質誘発性肺傷害を抑制する. 次世代を担う若手のためのファーマ・バイオフォーラム講演要旨集. 2023. 22nd
原俊太郎, 冨塚祐希, 桑田浩. 長鎖アシルCoA合成酵素ACSL4による肺における生体膜脂質酸化制御. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2023. 44th
冨塚祐希, 桑田浩, 原俊太郎. Analysis of the effects of long-chain acyl-CoA synthetase (ACSL)4 deficiency on drug-induced lung injury. 衛生薬学・環境トキシコロジー講演要旨集. 2023. 2023
田口央基, 藤代瞳, 冨塚祐希, 桑田浩, 原俊太郎, 姫野誠一郎, 姫野誠一郎, 角大悟. Investigation of the mechanism underlying the cytotoxicity induced by Cisplatin in proximal renal tubular region-derived cells. 日本薬学会年会要旨集(Web). 2023. 143rd

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Committee career (2)：

Awards (1)：

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