Fujiwara Daisuke

Affiliation and department：

Research field (4)： Molecular biochemistry , Chemical biology , Pharmaceuticals - chemistry and drug development , Applied biochemistry

Research theme for competitive and other funds (6)：

2022 - 2025 Drug Design: Helix-Loop-Helix peptide inhibitors of intracellular PTM-dependent PPIs
2016 - 2020 Development of the augmenting agent of cancer-specific immune responses and the inhibiter against the immune suppressive molecule for promoting cancer immunotherapy
2016 - 2019 A molecular design of molecular-targeting peptides (mid-size medicines) with cell membrane permeability.
2016 - 2018 Elucidation of Arf6 signaling mechanism to generate novel anticancer drugs
2014 - 2017 A method for generating molecular-targeting tools: Protein kinase-oriented library based on conformationally constrained peptide

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Papers (19)：

Kenta Morimoto, Jojiro Ishitobi, Kosuke Noguchi, Ryoichi Kira, Yukiya Kitayama, Yuto Goto, Daisuke Fujiwara, Masataka Michigami, Atsushi Harada, Tomoka Takatani-Nakase, et al. Extracellular Microvesicles Modified with Arginine-Rich Peptides for Active Macropinocytosis Induction and Delivery of Therapeutic Molecules. ACS Applied Materials & Interfaces. 2024
Kousuke Mihara, Natsumi Nakajima, Ikuo Fujii, Daisuke Fujiwara. Generation of inhibitory peptides for IKKε from a kinase-focused phage library of helix-loop-helix peptides. Peptide Science. 2022. e24253
Tharanga MR RAMANAYAKE MUDIYANSELAGE, Daisuke FUJIWARA, Masataka MICHIGAMI, Shunichi WATANABE, Zhengmao YE, Atsuko UEDA, Ryoji KANEGI, Shingo HATOYA, Ikuo FUJII, Kikuya SUGIURA. Generation of molecular-targeting helix-loop-helix peptides for inhibition of the interaction between cytotoxic T-lymphocyte-associated protein 4 and B7 in the dog. Journal of Veterinary Medical Science. 2022. 84. 8. 1101-1107
Setsu Nakae, Maho Kitamura, Daisuke Fujiwara, Masaaki Sawa, Tsuyoshi Shirai, Ikuo Fujii, Toshiji Tada. Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation. Acta crystallographica. Section F, Structural biology communications. 2021. 77. Pt 12. 459-464
Daisuke Fujiwara, Kousuke Mihara, Ryo Takayama, Yusuke Nakamura, Mitsuhiro Ueda, Takeshi Tsumuraya, Ikuo Fujii. Chemical Modification of Phage-Displayed Helix-Loop-Helix Peptides to Construct Kinase-Focused Libraries. Chembiochem : a European journal of chemical biology. 2021

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MISC (22)：

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Patents (2)：

Awards (1)：

2017/11 - 日本薬学会医薬化学部会日本薬学会医薬化学部会MCS優秀賞「ポスト抗体医薬品:立体構造規制ペプチド「マイクロ抗体」を土台とした中分子創薬」

Association Membership(s) (9)：

Protein Science Society of Japan , The Chemical Society of Japan , The Pharmaceutical Society of Japan , The Pharmaceutical Society of Japan, Division of Medicinal Chemistry , The Society for Biotechnology, Japan , The Japanese Peptide Society , バイオインタラクション研究会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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