Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Cell Functional Molecular Chemistry
About Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Cell Functional Molecular Chemistry
Research theme for competitive and other funds (25):
2021 - 2026 Development of cross-scale technologies for investigating correlations of structures, dynamics, and functions of intracellular molecules
2021 - 2026 Cross-scale biology
2020 - 2023 Novel technology of bio-functional control based on quantum beam technique for life science research
2019 - 2022 Development of optical technology for quantitative regulation of intracellular kinases
2019 - 2021 Spatiotemporal regulation of proteolysis based on photoreversible protein labeling technology
2018 - 2021 Development and biological application of photoreversible protein labeling technology
2018 - 2021 Analysis of ion dynamics in organelles by using targetable probes
2016 - 2018 Development of Photostable Supramolecular Fluorophores and Application to Bioimaging
2015 - 2018 Imaging and photoregulation of cellular functions by using functional molecule-protein hybrid probes
2015 - 2017 生体分子を利用した光駆動性分子ロボットハンドの開発
2012 - 2016 Development of highly sensitive in vivo imaging technology based on advanced functional nanoparticle design
2012 - 2015 Detection of antimicrobial peptide-based universal detection system of enzyme activities and its application to theranostics
2012 - 2014 光機能性プローブを用いた生体分子の小数活性化
2009 - 2011 Development of fusion molecular imaging technique based on functional molecular design
2009 - 2009 錯体化学に基づくマルチカラー磁気共鳴イメージング法の開発
2008 - 2009 可視化プローブの創製によるがん化プロセスのイメージング
2007 - 2008 Development of fluorescent probes that detect protein phosphorylation/dephosphorylation and their application
2007 - 2008 緩和時間変化型機能性MRIプローブのデザイン・合成・生物応用
2007 - 2008 生体シグナル可視化センシング
2007 - 2007 生きたまま分子機能を不活化するレーザー分子機能不活化プローブの開発
2006 - 2007 金属錯体の配位空間制御を応用した生体機能可視化センサー分子
2006 - 2007 分子プローブのデザイン・合成による細胞情報伝達に関わる蛋白質活性の可視化
2006 - 2007 可視化プローブの創製によるがん化プロセスのイメージング
2006 - 2007 Design and synthesis of visualization sensor molecules for bio-imaging
2006 - 2006 生体シグナル可視化センシング
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Papers (103):
Takato Mashita, Toshiyuki Kowada, Hayashi Yamamoto, Satoshi Hamaguchi, Toshizo Sato, Toshitaka Matsui, Shin Mizukami. Quantitative control of subcellular protein localization with a photochromic dimerizer. Nature Chemical Biology. 2024
Ira Novianti, Shin Mizukami. Cellsketch: Simplified Cell Representation for Label-free Cell and Nuclei Segmentation. Proceedings of 45th Annual International Conference of the IEEE EMBC 2023. 2023
Yusuke Matsui, Toshiyuki Kowada, Yi Ding, Priya Ranjan Sahoo, Kazuya Kikuchi, Shin Mizukami. Long-term Imaging of Intranuclear Mg2+ Dynamics during Mitosis Using a Localized Fluorescent Probe. Chemical Communications. 2023. 59. 46. 7048-7051
Yuta Amagai, Momo Yamada, Toshiyuki Kowada, Tomomi Watanabe, Yuyin Du, Rong Liu, Satoshi Naramoto, Satoshi Watanabe, Junko Kyozuka, Tiziana Anelli, et al. Zinc homeostasis governed by Golgi-resident ZnT family members regulates ERp44-mediated proteostasis at the ER-Golgi interface. Nature Communications. 2023. 14. 1. 2683-2683
Development of fast-blinking fluorophores for real-time single-molecule super-resolution imaging
(第23回東北大学多元物質科学研究所研究発表会 2023)
Development of localizable small-molecule fluorescent probes for quantitatively studying chemical proteostasis
(2023)
Development of optical regulation method for intracellular protein localization using photochromin protein dimerizer
(日本化学会秋季事業 第13回CSJ化学フェスタ2023 2023)
Development of photodegradation methods for tag-fusion proteins using photochromic compounds
(日本化学会秋季事業 第13回CSJ化学フェスタ2023 2023)
Exploring various tetrazine-distortions in the molecular design to tune the reactivity
(日本化学会秋季事業 第13回 CSJ化学フェスタ2023 2023)
THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
, THE RARE EARTH SOCIETY OF JAPAN
, THE BIOPHYSICAL SOCIETY OF JAPAN
, The American Chemical Society
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, 日本分子イメージング学会
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE CHEMICAL SOCIETY OF JAPAN