Rchr
J-GLOBAL ID：201801016878606800
Update date: May. 28, 2024
Watanabe Yoshihiro
ワタナベ ヨシヒロ | Watanabe Yoshihiro
Affiliation and department：
Job title：
Professor
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (5)：
MEK inhibitor
, drug discovery
, siganaling pathway in cancer
, Vaccine
, T cell and antibody
Research theme for competitive and other funds (2)：
- 2023 - 2026 AIT施行患者由来のアレルゲン認識組換えIgG4抗体における抑制性機能の解明
- 2020 - 2023 The proof-of-concept studies of Ab-inducing sublingual vaccine by clarifying affinity maturation of SLIT-induced antigen-specific IgGs.
Papers (33)：
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Hikaru Fujita, Sachiko Arai, Hiroshi Arakawa, Kana Hamamoto, Toshiyuki Kato, Tsubasa Arai, Nanaka Nitta, Kazuki Hotta, Natsuko Hosokawa, Takako Ohbayashi, et al. Drug-drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers. Bioorg Med Chem . 2024. 102. 117674
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Yoshihiro Watanabe, Natsuko Hosokawa, Misaki Yoshida, Tomoyuki Miura, Mitsuhiro Kawano. Identification of Closed Linear Epitopes in S1-RBD and S2-HR1/2 of SARS-CoV-2 Spike Protein Able to Induce Neutralizing Abs. Vaccines. 2023. 11. 2
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Paing Linn, Susumu Kohno, Jindan Sheng, Nilakshi Kulathunga, Hai Yu, Zhiheng Zhang, Dominic Voon, Yoshihiro Watanabe, Chiaki Takahashi. Targeting RB1 Loss in Cancers. Cancers. 2021. 13. 15. 3737-3737
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Shinji Sakamoto, Mika Kirinashizawa, Yumi Mohara, Yoshihiro Watanabe. Generation and characterization of monoclonal antibodies against mature hepcidin and its application to neutralization and quantitative alteration assay. Bioscience, Biotechnology, and Biochemistry. 2021. 85. 2. 340-350
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Susumu Kohno, Paing Linn, Naoko Nagatani, Yoshihiro Watanabe, Sharad Kumar, Tomoyoshi Soga, Chiaki Takahashi. Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. Oncogene. 2020. 39. 34. 5690-5707
ｍore...
Patents (13)：
Books (1)：
Lectures and oral presentations (5)：
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Identification of Neutralizing Ab-epitopes in SARS CoV-2 S Antigen and Their Utilization
(8th International Conference on Vaccines Research & Development. 2023)
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「理工系研究シーズの医療機器開発の促進事例;新規の中耳機能測定技術
(日本臨床試験学会 第14回学術集会総会 2023)
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耳小骨連鎖異常症例に対する簡易非侵襲診断機器の開発
(第123回日本耳鼻咽喉科頭頚部外科学会総会学術講演会 2022)
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Therapeutic Targeting of Monokine Production Is a Promising Strategy to Attenuate Cytokine-Release Syndrome in CAR-T Cell Therapy
(American Society of Hematology, 2019. 2019)
-
Clinical Success Story "Discovery of Trametinib as a MEK Inhibitor able to alter Phosphorylation state of MEK"
(Keystone Symposia "Phenotypic Drug Discovery" 2019)
Education (3)：
- - 1993 Kyoto University
- 1983 - 1985 Tohoku University
- 1977 - 1981 Tohoku University Faculty of Agriculture
Professional career (1)：
Work history (6)：
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