Rchr
J-GLOBAL ID：201801016878829915
Update date: Jun. 19, 2024
Mukai Yuji
ムカイ ユウジ | Mukai Yuji
Affiliation and department：
Job title：
病院講師
Research field (1)：
Clinical pharmacy
Research keywords (7)：
TDM
, Dried plasma spot
, Dried blood spot
, Drug-drug interaction
, LC-MS/MS
, Clinical pharmacokinetics
, Clinical pharmacology
Research theme for competitive and other funds (3)：
- 2022 - 2026 慢性骨髄性白血病患者を対象とした経口分子標的薬の来院不要な治療評価体制の構築
- 2018 - 2022 Development of simultaneous determination method of kinase inhibitors by means of dried blood spot sampling at home
- Development of system for therapeutic drug monitoring of BCR-ABL tyrosine kinase inhibitors by using finger-prick dried blood spot sampling at home
Papers (20)：
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Yuka Aida, Masahiro Ohgami, Yuji Mukai, Masashi Matsuyama, Mana Obata-Yasuoka, Toyomi Satoh, Masato Homma, Ikuo Sekine, Nobuyuki Hizawa. Pharmacokinetic study of erlotinib in a pregnant woman with advanced non-small cell lung cancer and observation of the effects on the child growth. British Journal of Clinical Pharmacology. 2024
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Yuji Mukai, Tatsunari Yoshida, Takeshi Kondo, Jun Miura, Nobuo Inotsume, Takaki Toda. Development and Validation of a Simple Method for Simultaneously Measuring the Concentrations of BCR-ABL and Bruton's Tyrosine Kinase Inhibitors in Dried Blood Spot (DBS): A Pilot Study to Obtain Candidate Conversion Equations for Predicting Plasma Concentration Based on DBS Concentration. Therapeutic Drug Monitoring. 2022. 44. 6. 762-770
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Yuji Mukai, Azusa Wakamoto, Tae Hatsuyama, Tatsunari Yoshida, Hideki Sato, Akihisa Fujita, Nobuo Inotsume, Takaki Toda. An LC-MS/MS method for the simultaneous determination of afatinib, alectinib, ceritinib, crizotinib, dacomitinib, erlotinib, gefitinib, and osimertinib in human serum. Therapeutic Drug Monitoring. 2021. 43. 6. 772-779
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Yuka Kato, Asuna Senda, Yuji Mukai, Miki Yamashita, Yuki Sasaoka, Minayo Hanada, Fuminori Hongo, Mitsugu Hirokami, Anders Rane, Nobuo Inotsume, et al. Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center. European journal of clinical pharmacology. 2021. 77. 6. 887-894
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Yuji Mukai, Yuka Yoshida, Tatsunari Yoshida, Takeshi Kondo, Nobuo Inotsume, Takaki Toda. Simultaneous Quantification of BCR-ABL and Bruton's Tyrosine Kinase Inhibitors in Dried Plasma Spots and Its Application to Clinical Sample Analysis. Therapeutic Drug Monitoring. 2020. 43. 3. 386-393
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MISC (4)：
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Yuji Mukai, Kosuke Doki, Yoshiharu Suzuki, Masato Homma. Utilizing the dry spot method to monitor the concentrations of biologic agents in breast milk. British Journal of Clinical Pharmacology. 2023
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Masquelier M, Löfgren H, Dubedout A, Mukai Y, Ericsson M. Detection of exogenous anabolic androgenic steroids in drugs-of-abuse urine samples with UHPLC-HRMS after enzymatic hydrolysis and direct injection. RECENT ADVANCES IN DOPING ANALYSIS. 2018. 26. 153-160
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Yuji Mukai. Reply to "Multiple and Opposite Effects of Angiotensin II Receptor Blockers on the Bioavailability of Epoxyeicosatrienoic Acids'. Basic & Clinical Pharmacology & Toxicology. 2017. 121. 4
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向 祐志. Dried blood spot:1滴の血液が切り拓く来院不要な新時代のTDM. ファルマシア. 2017. 53. 11. 1118-1118
Books (3)：
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基本が身につく・考え方がわかる エキスパートが教える薬物動態 2017年 10 月号 [雑誌]: 月刊薬事 増刊
じほう 2017
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個別化医療を目指した臨床薬物動態学 2(治療薬物モニタリング編)
広川書店 2016 ISBN:4567484916
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多面的症例解析演習-基礎分野・臨床分野から症例を俯瞰して...
京都廣川書店 2014 ISBN:4906992390
Lectures and oral presentations (35)：
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Venetoclax PK adjusted by Ven duration affected neutropenia after Ven-AzaC for AML
(The 85th annual meeting of the Japanese Society of Hematology 2023)
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白血病治療に用いられる分子標的薬のTDM
(第39回日本TDM学会・学術大会 2023)
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Dried blood spotsに基づくTDM
(第39回日本TDM学会・学術大会 2023)
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Dried blood spotsを用いたチロシンキナーゼ阻害薬の来院不要なTDM体制の構築を目指して
(TDM研究 2022)
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出産前後にエルロチニブ及びその代謝物の血中濃度測定を行った妊娠症例
(TDM研究 2022)
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Education (2)：
- 2012 - 2013 Hokkaido Pharmaceutical University School of Pharmacy
- 2007 - 2009 Hokkaido Pharmaceutical University School of Pharmacy
Professional career (1)：
Work history (6)：
Committee career (4)：
- 2024 - 現在 日本TDM学会 編集委員
- 2023/09 - 現在 Pharmaceutics Topical Advisory Panel Member
- 2022/12 - 現在 日本臨床薬理学会 評議員
- 2022/07 - 現在 International Association of Therapeutic Drug Monitoring and Clinical Toxicology Alternative Sampling Strategies Committee
Association Membership(s) (6)：
International Association of Therapeutic Drug Monitoring and Clinical Toxicology
, 日本病院薬剤師会
, 日本TDM学会
, 日本薬学会
, 日本臨床薬理学会
, 日本医療薬学会
