Kobayashi Hiroki

Affiliation and department：

Research field (1)： Applied biochemistry

Research theme for competitive and other funds (5)：

2021 - 2024 HMGA2高発現による骨髄異形成症候群の器質化肺炎誘導メカニズム解析
2019 - 2021 A study on the mechanism regulating cell motility upon metabolic alterations by PFK1 inhibition
2016 - 2018 The mechanism of action of a novel small molecule that represses the Warburg effect
2014 - 2017 遺伝学・化学遺伝学によるがん・多能性幹細胞の代謝制御機構解析
2013 - 2015 分化および初期化に伴うミトコンドリアの構造的変化とタンパク質化学修飾変化の解析

Papers (14)：

Natsumi Matsunuma, Yoshihiro Hayashi, Marina Fukuda, Kanako Yuki, Yasushige Kamimura-Aoyagi, Hiroki Kobayashi, Naoki Shingai, Yuka Harada, Hironori Harada. HMGA2 promotes platelet-neutrophil complex formation and pulmonary tissue damage in myelodysplastic syndromes. Blood Vessels, Thrombosis & Hemostasis. 2024
Hiroki Kobayashi, Shohei Takase, Haruna Nishimura, Ken Matsumoto, Hironori Harada, Minoru Yoshida. RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells. Cancer Science. 2023
Majid Manzoor, Makoto Muroi, Naoko Ogawa, Hiroki Kobayashi, Haruna Nishimura, Danni Chen, Opeyemi B. Fasina, Jianyu Wang, Hiroyuki Osada, Minoru Yoshida, et al. Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo. Food & Function. 2022
Yusuke Ogura, Hiroki Kobayashi, Masaya Imoto, Hidenori Watanabe, Hirosato Takikawa. Unified synthesis and assessment of tumor cell migration inhibitory activity of optically active UTKO1, originally designed moverastin analog. Bioscience, Biotechnology, and Biochemistry. 2021. 85. 1. 160-167
Hiroki Kobayashi, Hideyuki Hatakeyama, Haruna Nishimura, Mutsumi Yokota, Sadafumi Suzuki, Yuri Tomabechi, Mikako Shirouzu, Hiroyuki Osada, Masakazu Mimaki, Yu-ichi Goto, et al. Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations. Nature Chemical Biology. 2020. 17. 3. 335-343

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MISC (10)：

HIF signaling in aging and hematological malignancy. HEMATOLOGY. 2023. 87. 3. 284-289
小林大貴, 吉田稔. 機能低下したミトコンドリアを活性化させる化合物の発見. 実験医学 2021年4月号. 2021. 39. 6. 954-957
小林大貴, 伊藤昭博. エピジェネティクスに基づく技術開発と創薬 (特集アレルギーとエピジェネティクス). アレルギー・免疫. 2014. 21. 12. 1856-1863
Akihiro Ito, Hiroki Kobayashi, Minoru Yoshida. ヒストン修飾酵素を標的としたエピジェネティクス創薬. エピジェネティクスの産業応用. 2014
Hiroki Kobayashi, Ito Akihiro. エピジェネティクスに基づく技術開発と創薬. アレルギー・免疫. 2014. 21. 12. 28-35

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Lectures and oral presentations (5)：

A novel compound that alters energy metabolism
(The Joint Symposium of "10th Korea-Japan Chemical Biology Symposium" and "30th Meeting for New Drug Discovery" 2019)
創薬科学への招待
(創薬科学への招待(研究所見学会) 2019)
ケミカルバイオロジーによる代謝制御機構解析と応用
(天然物化学特論(東京薬科大学大学院生命科学研究科) 2018)
ケミカルジェネティクスによる代謝制御機構解析
(生命科学特論(慶應義塾大学大学院生命システム情報専修) 2016)
天然からの抗がん剤探索
(山梨県吉田高校出張講義 2009)

Awards (6)：

2023/06 - The Japanese Association for Molecular Target Therapy of Cancer 研究奨励賞
2021/03 - RIKEN Ohbu Research Incentive Award Mechanisms of energy metabolism regulation revealed by chemical biology approach
2021/02 - The Japanese Society of Mitochondrial Research and Medicine J-mit 特別オンラインシンポジウム最優秀発表賞
2019/10 - CSHA Cold Spring Harbor Asia Poster Fellowship "Identification of a novel compound that alters energy metabolism"
2019/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) Selected Presentation A Chemical Genetic Study on the Regulation of the Warburg Effect

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