Akanuma Shin-ichi

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Clinical pharmacy

Research keywords (3)： Blood-retinal barrier , Blood-brain barrier , Pharmaceutics

Research theme for competitive and other funds (14)：

2022 - 2025 Transport mechanisms of cell-penetrating peptides at the blood-retinal barrier to establish strategies of macromolecular drug delivery
2020 - 2023 血液精巣関門インフラックス輸送機構の解明と精巣内薬物送達への応用
2019 - 2022 Establishing ex vivo methods to elucidate efflux transport of drugs at the blood-retinal barrier for retinal drug development
2017 - 2020 Study of cationic drug efflux across the blood-retinal barrier
2016 - 2019 The foundation of developing drugs for retinal diseases by pharmaceutical drug-repositioning screening based on the distribution manner via the blood-retinal barrier

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Papers (93)：

Kosuke Tajima, Shin-Ichi Akanuma, Yuki Ohishi, Yukiko Yoshida, Björn Bauer, Yoshiyuki Kubo, Masahiko Inouye, Ken-Ichi Hosoya. Freshly isolated retinal capillaries to determine efflux transporter function at the inner BRB. Journal of controlled release : official journal of the Controlled Release Society. 2022. 343. 434-442
Katsuki Takashima, Takuya Okada, Atsushi Kato, Yuhei Yamasaki, Takeshi Sugouchi, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya, Hiroyuki Morita, Takuya Ito, et al. Divergent synthesis of decahydroquinoline-type poison-frog alkaloids. ChemistrySelect. 2022. 7. 5. e202104533
Shin-Ichi Akanuma, Myeongrae Han, Yuka Murayama, Yoshiyuki Kubo, Ken-Ichi Hosoya. Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier. Pharmaceutical research. 2022. 39. 2. 223-237
Yoshiyuki Kubo, Sakiko Ishizuka, Takeru Ito, Daisuke Yoneyama, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Involvement of TauT/SLC6A6 in Taurine Transport at the Blood-Testis Barrier. Metabolites. 2022. 12. 1
Takuya Okada, Naizhen Wu, Katsuki Takashima, Jungoh Ishimura, Hiroyuki Morita, Takuya Ito, Takeshi Kodama, Yuhei Yamasaki, Shin-ichi Akanuma, Yoshiyuki Kubo, et al. Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent-cis-195A and cis-211A. Molecules. 2021. 26. 24. 7529-7529

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MISC (11)：

Yoshiyuki Kubo, Masakazu Yamamoto, Kensuke Matsunaga, Shin-Ichi Akanuma, Ken-Ichi Hosoya. INVOLVEMENT OF PLASMA MEMBRANE MONOAMINE TRANSPORTER (PMAT/SLC29A4) IN RETINA-TO-BLOOD TRANSPORT OF MPP plus ACROSS THE BLOOD-RETINAL BARRIER. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S100-S101
Takuya Usui, Yoshiyuki Kubo, Shin-ichi Akanuma, Ken-ichi Hosoya. INVOLVEMENT OF PMAT IN HISTAMINE EFFLUX FROM THE CEREBROSPINAL FLUID ACROSS THE BLOOD-CEREBROSPINAL FLUID BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 291-292
Yuma Tega, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya. NICOTINE TRANSPORT IN THE RAT BLOOD-BRAIN BARRIER AND LIVER: INVOLVEMENT OF THE PROTON-COUPLED ORGANIC CATION ANTIPORTER. DRUG METABOLISM REVIEWS. 2015. 47. 294-294
Yoshiyuki Kubo, Ai Tsuchiyama, Yoshimi Shimizu, Shin-ichi Akanuma, Ken-ichi Hosoya. THE BLOOD-TO-RETINA TRANSPORT OF CLONIDINE AT THE INNER BLOOD-RETINAL BARRIER. DRUG METABOLISM REVIEWS. 2015. 47. 292-293
赤沼伸乙, 久保義行, 細谷健一. タウリンの体内動態とその動態にトランスポーターが果たす役割 (特集第1回国際タウリン研究会日本部会プロシーディングス). タウリンリサーチ = Japanese journal of taurine research. 2015. 1. 1. 44-46

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Professional career (1)：

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