Research theme for competitive and other funds (18)：
2023 - 2026 The elucidation of pathogenesis of beta cell plasticity associated dedifferentiation in diabetes mellitus
2021 - 2024 臓器間ネットワークによる膵α細胞新生機構と代謝制御の解明
2020 - 2023 The elucidation of Txnip-dependent mechanisms in pancreatic beta cell dedifferentiation leading diabetes
2018 - 2021 Elucidation of the mechanism of pancreatic alfa cell mass increase and white adipocyte browning induced by a low-carbohydrate/high-protein diet
2016 - 2019 The elucidation of the mechanisms underlying beta cell dedifferentiation and plasticity in diabetes
2015 - 2018 Peripheral Circadian Dysregulation and Metabolic Disorders
2013 - 2016 The elucidation of roles of GSK3 on the regulation of energy metabolism for developing therapeutic strategy of T2DM
2013 - 2014 WFS1欠損によるβ細胞機能障害とインクレチンの効果に関する研究
2011 - 2014 Investigation of the mechanism of beta-cell failure in diabetes using Wolfram Syndrome as a model
2010 - 2013 GSK-3βの膵β細胞量調節機構の解明とその制御による2型糖尿病治療の研究
2010 - 2012 GSK-3βの膵β細胞量調節機構の解明とその制御による2型糖尿病治療の研究
2010 - 2012 Investigation of roles of GSK-3β in the regulation of pancreatic β cell mass for the application to the treatment of type 2 diabetes mellitus.
2009 - 2011 Gsk-3βの膵β細胞量調節機構解明とその制御による糖尿病治療の研究
2009 - 2010 セリンスレオニンキナーゼGSK-3βの膵β細胞における分子機能の解明
2004 - 2005 Molecular Pathophysiology of Wolfram Syndrome and Endoplasmic Reticulum Stress-associated Pancreatic β-cell Failure.
2004 - 2004 ゲノム資源を用いた糖尿病発症遺伝素因としてのERストレス関連分子の探求
2003 - 2004 The Development of the Model Mice Having the System that Easily Measuring their Pancreatic Islet Beta Cell Mass
2002 - 2003 Investigation of the roles of WFS1 and glutamate dehydorogenase on the pancreatic β-cell function and regulation of insulin secretion
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Papers (53)：
Shuntaro Morikawa, Katsuya Tanabe, Naoya Kaneko, Nozomi Hishimura, Akie Nakamura. Comprehensive overview of disease models for Wolfram syndrome: toward effective treatments. Mammalian genome : official journal of the International Mammalian Genome Society. 2024. 35. 1. 1-12
Hiraku Tokuma, Daisuke Sakano, Katsuya Tanabe, Yukio Tanizawa, Nobuaki Shiraki, Shoen Kume. Selective proteasome degradation of C-terminally-truncated human WFS1 in pancreatic beta cells. FEBS open bio. 2023. 13. 8. 1405-1414
Syota Kagawa, Katsuya Tanabe, Makoto Hiromura, Kakuyou Ogawa, Takayuki Koga, Takahiro Maeda, Kikuko Amo-Shiinoki, Hiroyuki Ochi, Yui Ichiki, Shogo Fukuyama, et al. Hachimijiogan, a traditional herbal medicine, modulates adipose cell function and ameliorates diet-induced obesity and insulin resistance in mice. Frontiers in pharmacology. 2023. 14. 1167934
Shogo Amano, Shigeyuki Suenaga, Kaori Hamamoto, Shoko Yada, Takanori Tsuyama, Shuhei Shinoda, Yuya Tanaka, Yoshihiro Takemoto, Eijiro Harada, Katsuya Tanabe, et al. A case of multiple glucagonomas with no clinical manifestations of excess glucagon despite hyperglucagonemia. DEN open. 2023. 3. 1. e230
Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanabe. Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells. International journal of molecular sciences. 2022. 23. 21
1989 - 1995 Yamaguchi University School of Medicine Faculty of Medicine
Professional career (1)：
医学博士 (山口大学)
Work history (5)：
2023/08 - 現在 山口大学大学院医学系研究科 病態制御内科学講座 准教授
2016/04 - 2023/07 Yamaguchi University hospital The third department of medicine Associate professor
2009/04 - 2016/03 山口大学医学部附属病院 第三内科 助教
2008/08 - 2009/03 ヒューマンサイエンス振興財団 研究員
2005/07 - 2008/07 Washington University division of endocrinology, metabolism and lipid research post doctor fellow
Committee career (2)：
2019/07 - 現在 日本糖尿病学会 評議員
2017/04 - 現在 日本内科学会中国支部 評議員
Awards (5)：
2012/11 - Banyu Life Science Foundation International Banyu Medical Award
2011/03 - UBE INDUSTRIES FOUNDATION Watanabe memorial scientific award
2009/08 - 2nd Asia Islet Biology & Incretin Symposium The award for outstanding scientific achievement and presentation Glucose and Fatty Acids Promote Pancreatic Beta-Cell Apoptosis through Synergistic Effects on ER stress and impaired Insulin Signaling
2008/11 - Young Investigator Award
2008/08 - 1st Asia Islet Biology & Incretin Symposium The outstanding scientific research Award Genetic deficiency of glycogen-synthase kinase-3β corrects diabetes in the mouse models of insulin resistance.
Association Membership(s) (4)：
The Japan Endocrine Society
, THE JAPAN DIABETES SOCIETY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, 日本病態栄養学会
