Kobayashi Kazuya

Affiliation and department：

Research field (1)： Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (6)：

2023 - 2026 Development of novel macrocyclic BACE1 inhibitors for preventive or therapeutic agents for Alzheimer's disease
2022 - 2025 受容体共役因子によるB型肝炎ウイルス感染制御と創薬研究
2020 - 2023 Development of a versatile design method for protease inhibitors based on hydroxyproline
2015 - 2017 Development of novel BACE1 inhibitors based on the N-amidino nitrogen-containing ring structure
2013 - 2015 Development of novel BACE1 inhibitors: Structure activity relationship study based on the substrate sequence

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Papers (37)：

Chiyuki Awahara, Daiki Oku, Kazuya Kobayashi, Yasunao Hattori. Evaluating a Retro-Inverso Type Inhibitor of HTLV-1 Protease as a Competitive Inhibitor. Chemical & pharmaceutical bulletin. 2024. 72. 3. 309-310
Rikito Suzuki, Daphne R. Mattos, Takashi Kitamura, Rina Tsujioka, Kazuya Kobayashi, Shinsuke Inuki, Hiroaki Ohno, Jane E. Ishmael, Kerry L. McPhail, Shinya Oishi. Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A. ACS Medicinal Chemistry Letters. 2023
Chiyuki Awahara, Daiki Oku, Saki Furuta, Kazuya Kobayashi, Kenta Teruya, Kenichi Akaji, Yasunao Hattori. The Effects of Side-Chain Configurations of a Retro-Inverso-Type Inhibitor on the Human T-Cell Leukemia Virus (HTLV)-1 Protease. Molecules (Basel, Switzerland). 2022. 27. 5
Takuya Otani, Yasunao Hattori, Kenichi Akaji, Kazuya Kobayashi. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure. Bioorganic & medicinal chemistry. 2021. 52. 116517-116517
Kazuya Kobayashi, Takuya Otani, Saki Ijiri, Yuki Kawasaki, Hiroki Matsubara, Takahiro Miyagi, Taishi Kitajima, Risa Iseki, Katsuyasu Ishizawa, Naoka Shindo, et al. Structure-activity relationship study of hydroxyethylamine isostere and P1' site structure of peptide mimetic BACE1 inhibitors. Bioorganic & medicinal chemistry. 2021. 50. 116459-116459

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MISC (17)：

川北百花, 大谷拓也, 服部恭尚, 大石真也, 小林数也. Structure-activity relationship study on the P4 structure of a macrocyclic BACE1 inhibitor. 日本薬学会年会要旨集(Web). 2023. 143rd
辻岡里菜, 鈴木力斗, 鈴木力斗, MATTOS Daphne R., 小林数也, ISHMAEL Jane E., MCPHAIL Kerry L., 大石真也, 大石真也. Structure-Activity Relationship Study of Coibamide A Derivatives: Transformation of N-Terminal Tail Region. 日本薬学会年会要旨集(Web). 2023. 143rd
Kazuya Kobayashi, Takuya Otani, Yasunao Hattori, Kenichi Akaji. Synthesis and Structural Optimization of Macrocyclic BACE1 Inhibitors with a Hydrophobic Cross-Linked Structure. Proceedings of the 36th European and the 12th International Peptide Symposium. 2022. 137-140
只野響, 内山良介, 小林数也, 林麻利亜, 遠藤祐里奈, 赤路健一, 野坂和人. ピロリ菌のチアミン輸送タンパク質PnuTの生化学的性質と基質認識部位. 日本薬学会年会要旨集. 2018. 138年会. 3. 174-174
只野響, 内山良介, 小林数也, 林麻利亜, 遠藤祐里奈, 赤路健一, 野坂和人. ピロリ菌のチアミン輸送タンパク質PnuTの生化学的性質と基質認識部位. 日本薬学会年会要旨集. 2018. 138年会. 3. 174-174

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Lectures and oral presentations (13)：

ヒドロキシプロリンを母核とするプロテアーゼ阻害剤の設計とBACE1阻害剤探索への適用
(第40回メディシナルケミストリーシンポジウム 2023)
ピロリジン環を基盤とするプロテアーゼ阻害剤設計とBACE1阻害剤への展開
(第73回日本薬学会関西支部総会・大会 2023)
Coibamide Aの構造活性相関研究:N末端の直鎖状構造の変換
(第55回若手ペプチド夏の勉強会 2023)
大環状BACE1阻害剤を基盤とするP4位置換基の構造活性相関研究
(日本薬学会第143年会 2023)
Coibamide Aの構造活性相関研究:N末端の直鎖状構造の変換
(日本薬学会第143年会 2023)

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