Hayato Hikita

2020 - 2023 The effect of elevated TNF-alfa on the pathogenesis of chronic pancreatitis

2021 - 2022 肝発癌および肝癌微小環境におけるLIFの生物学的意義の解析

2018 - 2021 Cell-to-cell communication and pathogenesis triggered by hepatocyte cell death in the liver

2017 - 2020 Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapy

2017 - 2020 Discovery of HCC progression-related cancer genes through in vivo forward genetic screen

2017 - 2020 Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver disease

2017 - 2020 Intracellular trafficking in liver disease

2017 - 2020 The effect of insulin insufficiency and/or insulin resistance on pancreatic carcinogenesis and progression

2016 - 2018 Treatment for acute pancreatitis by regulating autophagy which modulates zymogen granules and inflammasomes

2016 - 2018 Examination of the mechanisms of which radiation induces liver disorder for expanding radiation therapy

2014 - 2018 The impact of hepatocyte apoptosis and autophagy in the process of livercarcinogenesis

2015 - 2017 Development of a liver carcinogenesis model using human hepatocytes and searching suitable anti-cancer drugs considering mutated genes.

2014 - 2016 Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression

2012 - 2015 Continuous hepatocyte apoptosis induces HCC in the liver

2012 - 2014 Molecular mechanisms of acinar cell injury in acute pancreatitis

2011 - 2014 Regulation of autophagy and its impact in the development and progression of hepatocellular cancer.